ZN37A_HUMAN
ID ZN37A_HUMAN Reviewed; 561 AA.
AC P17032; B3KRQ3; D3DRZ3; Q96B88;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 3.
DT 03-AUG-2022, entry version 197.
DE RecName: Full=Zinc finger protein 37A;
DE AltName: Full=Zinc finger protein KOX21;
GN Name=ZNF37A; Synonyms=KOX21, ZNF37;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12566394; DOI=10.1101/gr.644503;
RA Guy J., Hearn T., Crosier M., Mudge J., Viggiano L., Koczan D.,
RA Thiesen H.-J., Bailey J.A., Horvath J.E., Eichler E.E., Earthrowl M.E.,
RA Deloukas P., French L., Rogers J., Bentley D., Jackson M.S.;
RT "Genomic sequence and transcriptional profile of the boundary between
RT pericentromeric satellites and genes on human chromosome arm 10p.";
RL Genome Res. 13:159-172(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 320-561.
RX PubMed=8464732; DOI=10.1093/nar/21.6.1409;
RA Tunnacliffe A., Liu L., Moore J.K., Leversha M.A., Jackson M.S.,
RA Ferguson-Smith M.A., Thiesen H.-J., Ponder B.A.;
RT "Duplicated KOX zinc finger gene clusters flank the centromere of human
RT chromosome 10: evidence for a pericentric inversion during primate
RT evolution.";
RL Nucleic Acids Res. 21:1409-1417(1993).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 327-382.
RC TISSUE=Lymphoid tissue;
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
RN [8]
RP INDUCTION, AND SUBCELLULAR LOCATION.
RX PubMed=23922231; DOI=10.1093/hmg/ddt373;
RA Gauthier M., Marteyn A., Denis J.A., Cailleret M., Giraud-Triboult K.,
RA Aubert S., Lecuyer C., Marie J., Furling D., Vernet R., Yanguas C.,
RA Baldeschi C., Pietu G., Peschanski M., Martinat C.;
RT "A defective Krab-domain zinc-finger transcription factor contributes to
RT altered myogenesis in myotonic dystrophy type 1.";
RL Hum. Mol. Genet. 22:5188-5198(2013).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23922231}.
CC -!- INDUCTION: Down-regulated in cells with DM1 (Myotonic dystrophy type 1)
CC mutation, via a mechanism that involves abnormal control of its mRNA
CC stability by CUGBP1. {ECO:0000269|PubMed:23922231}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AJ492195; CAD37331.1; -; mRNA.
DR EMBL; AK092012; BAG52465.1; -; mRNA.
DR EMBL; AL117339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471072; EAW85885.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW85886.1; -; Genomic_DNA.
DR EMBL; BC015858; AAH15858.1; -; mRNA.
DR EMBL; X69115; CAA48868.1; -; mRNA.
DR EMBL; X52352; CAA36578.1; -; mRNA.
DR CCDS; CCDS31183.1; -.
DR PIR; S30238; S30238.
DR RefSeq; NP_001007095.1; NM_001007094.2.
DR RefSeq; NP_001171572.1; NM_001178101.1.
DR RefSeq; NP_001311174.1; NM_001324245.1.
DR RefSeq; NP_001311175.1; NM_001324246.1.
DR RefSeq; NP_001311176.1; NM_001324247.1.
DR RefSeq; NP_001311177.1; NM_001324248.1.
DR RefSeq; NP_001311178.1; NM_001324249.1.
DR RefSeq; NP_001311179.1; NM_001324250.1.
DR RefSeq; NP_001311180.1; NM_001324251.1.
DR RefSeq; NP_003412.1; NM_003421.2.
DR RefSeq; XP_011517958.1; XM_011519656.2.
DR RefSeq; XP_011517959.1; XM_011519657.2.
DR RefSeq; XP_011517960.1; XM_011519658.2.
DR AlphaFoldDB; P17032; -.
DR SMR; P17032; -.
DR BioGRID; 113415; 3.
DR IntAct; P17032; 1.
DR iPTMnet; P17032; -.
DR PhosphoSitePlus; P17032; -.
DR BioMuta; ZNF37A; -.
DR DMDM; 85681861; -.
DR jPOST; P17032; -.
DR MassIVE; P17032; -.
DR MaxQB; P17032; -.
DR PaxDb; P17032; -.
DR PeptideAtlas; P17032; -.
DR PRIDE; P17032; -.
DR ProteomicsDB; 53435; -.
DR Antibodypedia; 823; 176 antibodies from 22 providers.
DR DNASU; 7587; -.
DR Ensembl; ENST00000351773.7; ENSP00000329141.3; ENSG00000075407.19.
DR Ensembl; ENST00000361085.9; ENSP00000354377.4; ENSG00000075407.19.
DR Ensembl; ENST00000685332.1; ENSP00000508865.1; ENSG00000075407.19.
DR GeneID; 7587; -.
DR KEGG; hsa:7587; -.
DR MANE-Select; ENST00000685332.1; ENSP00000508865.1; NM_001324250.3; NP_001311179.1.
DR UCSC; uc001izk.4; human.
DR CTD; 7587; -.
DR DisGeNET; 7587; -.
DR GeneCards; ZNF37A; -.
DR HGNC; HGNC:13102; ZNF37A.
DR HPA; ENSG00000075407; Low tissue specificity.
DR MIM; 616085; gene.
DR neXtProt; NX_P17032; -.
DR OpenTargets; ENSG00000075407; -.
DR PharmGKB; PA37677; -.
DR VEuPathDB; HostDB:ENSG00000075407; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162764; -.
DR HOGENOM; CLU_002678_0_12_1; -.
DR InParanoid; P17032; -.
DR OMA; VFGVQQR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17032; -.
DR TreeFam; TF337898; -.
DR PathwayCommons; P17032; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P17032; -.
DR BioGRID-ORCS; 7587; 14 hits in 1094 CRISPR screens.
DR ChiTaRS; ZNF37A; human.
DR GeneWiki; ZNF37A; -.
DR GenomeRNAi; 7587; -.
DR Pharos; P17032; Tdark.
DR PRO; PR:P17032; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; P17032; protein.
DR Bgee; ENSG00000075407; Expressed in parotid gland and 176 other tissues.
DR ExpressionAtlas; P17032; baseline and differential.
DR Genevisible; P17032; HS.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..561
FT /note="Zinc finger protein 37A"
FT /id="PRO_0000047367"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 146..168
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 243..265
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..293
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 327..349
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 355..377
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 383..405
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 411..433
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 439..461
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 467..489
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 495..517
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 523..545
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 105
FT /note="D -> N (in dbSNP:rs2021319)"
FT /id="VAR_052753"
SQ SEQUENCE 561 AA; 65418 MW; 068789DC7DA04BC3 CRC64;
MITSQGSVSF RDVTVGFTQE EWQHLDPAQR TLYRDVMLEN YSHLVSVGYC IPKPEVILKL
EKGEEPWILE EKFPSQSHLE LINTSRNYSI MKFNEFNKGG KCFCDEKHEI IHSEEEPSEY
NKNGNSFWLN EDLIWHQKIK NWEQSFEYNE CGKAFPENSL FLVHKRGYTG QKTCKYTEHG
KTCDMSFFIT HQQTHPRENH YGNECGENIF EESILLEHQS VYPFSQKLNL TPIQRTHSIN
NIIEYNECGT FFSEKLVLHL QQRTHTGEKP YECHECGKTF TQKSAHTRHQ RTHTGGKPYE
CHECGKTFYK NSDLIKHQRI HTGERPYGCH ECGKSFSEKS TLTQHQRTHT GEKPYECHEC
GKTFSFKSVL TVHQKTHTGE KPYECYACGK AFLRKSDLIK HQRIHTGEKP YECNECGKSF
SEKSTLTKHL RTHTGEKPYE CIQCGKFFCY YSGFTEHLRR HTGEKPFGCN ECGKTFRQKS
ALIVHQRTHI RQKPYGCNQC GKSFCVKSKL IAHHRTHTGE KPYECNVCGK SFYVKSKLTV
HQRIHLGRNP INVVNEGNYS G
