ID   ZN383_MACFA             Reviewed;         475 AA.
AC   Q4R6C2;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Zinc finger protein 383;
GN   Name=ZNF383; ORFNames=QtsA-18358;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a transcriptional repressor, suppressing
CC       transcriptional activities mediated by MAPK signaling pathways.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttling between the nucleus and cytoplasm may occur under
CC       different stimulation and growth conditions. {ECO:0000250}.
CC   -!- DOMAIN: The KRAB domain is responsible for the transcriptional
CC       repressor activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AB169263; BAE01353.1; -; mRNA.
DR   RefSeq; NP_001271075.1; NM_001284146.1.
DR   RefSeq; XP_005589076.1; XM_005589019.2.
DR   RefSeq; XP_005589079.1; XM_005589022.2.
DR   RefSeq; XP_005589081.1; XM_005589024.2.
DR   RefSeq; XP_005589082.1; XM_005589025.2.
DR   RefSeq; XP_005589083.1; XM_005589026.2.
DR   RefSeq; XP_005589084.1; XM_005589027.2.
DR   RefSeq; XP_005589085.1; XM_005589028.2.
DR   RefSeq; XP_015296402.1; XM_015440916.1.
DR   RefSeq; XP_015296403.1; XM_015440917.1.
DR   RefSeq; XP_015296404.1; XM_015440918.1.
DR   AlphaFoldDB; Q4R6C2; -.
DR   SMR; Q4R6C2; -.
DR   STRING; 9541.XP_005589076.1; -.
DR   GeneID; 101865100; -.
DR   KEGG; mcf:101865100; -.
DR   CTD; 163087; -.
DR   VEuPathDB; HostDB:ENSMFAG00000039340; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   OMA; YIPKPQV; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000233100; Chromosome 19.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 8.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 6.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..475
FT                   /note="Zinc finger protein 383"
FT                   /id="PRO_0000047551"
FT   DOMAIN          6..77
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         170..192
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         198..220
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         226..248
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         254..276
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         282..304
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         310..332
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         338..360
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         366..388
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         394..416
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         422..444
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         450..472
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   475 AA;  54626 MW;  10416E124D764EF5 CRC64;
     MAEGSVMFSD VSIDFSQEEW DCLDPVQRDL YRDVMLENYS NLVSMGLYTP KPQVISLLEQ
     GKEPWMVGRE LTRGLCSDLE SMCETKLLSL KKEVYEIELC QREIMGLTKH GLEYSSFGDV
     LEYRSRLAKQ LGYPNGHFSQ EIFTPEYMPT FIQQTFLTLQ QIMNNEDRPF ECKKCGKAFS
     QNSQFIQHQR IHIGEKSYEC KECGKFFSCG SHVTRHLKIH TGEKPFECKE CGKAFSCSSY
     LSQHQRIHTG KKPYECKECG KAFSYCSNLI DHQRIHTGEK PYACKVCGKA FTKSSQLFQH
     VRIHTGEKPY ECKECGKAFT QSSKLVQHQR IHTGEKPYEC KECGKAFSSG SALTNHQRIH
     TGEKPYDCKE CGKAFTQSSQ LRQHQRIHAG EKPFECLECG KAFTQNSQLF QHQRIHTDEK
     PYECNECGKA FNKCSNLTRH LRIHTGEKPY NCKECGKAFS SGSDLIRHQG IHTNE