CC50C_PANTR
ID CC50C_PANTR Reviewed; 157 AA.
AC A0ZT23; A0ZT24;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Cell cycle control protein 50C;
DE AltName: Full=Transmembrane protein 30C;
GN Name=TMEM30C; Synonyms=CDC50C;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 46-157 (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [MRNA] OF 46-157 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17258408; DOI=10.1016/j.gene.2006.11.021;
RA Osada N., Hashimoto K., Hirai M., Kusuda J.;
RT "Aberrant termination of reproduction-related TMEM30C transcripts in the
RT hominoids.";
RL Gene 392:151-156(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A0ZT23-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0ZT23-2; Sequence=VSP_026451, VSP_026452;
CC -!- SIMILARITY: Belongs to the CDC50/LEM3 family. {ECO:0000305}.
CC -!- CAUTION: According to PubMed:17258408, chimpanzee like human only
CC express a C-terminally truncated protein compared to orthologs.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB265818; BAF41211.1; -; mRNA.
DR EMBL; AB265819; BAF41212.1; -; mRNA.
DR AlphaFoldDB; A0ZT23; -.
DR STRING; 9598.ENSPTRP00000056080; -.
DR PaxDb; A0ZT23; -.
DR eggNOG; KOG2952; Eukaryota.
DR InParanoid; A0ZT23; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045332; P:phospholipid translocation; IBA:GO_Central.
DR InterPro; IPR005045; CDC50/LEM3_fam.
DR InterPro; IPR030353; TMEM30C.
DR PANTHER; PTHR10926; PTHR10926; 1.
DR PANTHER; PTHR10926:SF54; PTHR10926:SF54; 1.
DR Pfam; PF03381; CDC50; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..157
FT /note="Cell cycle control protein 50C"
FT /id="PRO_0000292848"
FT TOPO_DOM 1..34
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..157
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 102..113
FT /note="GNVYMYYKLYGF -> VGEIQETQLTLH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17258408"
FT /id="VSP_026451"
FT VAR_SEQ 114..157
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17258408"
FT /id="VSP_026452"
SQ SEQUENCE 157 AA; 18527 MW; 4EC0CDBB35FB568C CRC64;
MEERAQHCLS RLLDNSALKQ QELPIHRLYF TARRVLFVFF ATGIFCLCMG IILILSARST
QEIEINYTRI CANCAKLQEN ASNFDKECTC SIPFYLSGKM MGNVYMYYKL YGFYQNLYLY
IRSRSNRQLV GKDVKVRLNL IWYNTLFLFL NQVDFSV
