ZN398_HUMAN
ID ZN398_HUMAN Reviewed; 642 AA.
AC Q8TD17; A8K384; B4E377; Q8TD18; Q9P2K7; Q9UDV8;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Zinc finger protein 398;
DE AltName: Full=Zinc finger DNA-binding protein p52/p71;
GN Name=ZNF398; Synonyms=KIAA1339, ZER6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=11779858; DOI=10.1074/jbc.m107702200;
RA Conroy A.T., Sharma M., Holtz A.E., Wu C., Sun Z., Weigel R.J.;
RT "A novel zinc finger transcription factor with two isoforms that are
RT differentially repressed by estrogen receptor-alpha.";
RL J. Biol. Chem. 277:9326-9334(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ASP-87.
RC TISSUE=Brain, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 234-642.
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [7]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-265, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: Functions as a transcriptional activator.
CC -!- INTERACTION:
CC Q8TD17; P29972: AQP1; NbExp=3; IntAct=EBI-8643207, EBI-745213;
CC Q8TD17; Q9NX04: C1orf109; NbExp=4; IntAct=EBI-8643207, EBI-8643161;
CC Q8TD17; Q9NP86: CABP5; NbExp=3; IntAct=EBI-8643207, EBI-10311131;
CC Q8TD17; O14647-3: CHD2; NbExp=3; IntAct=EBI-8643207, EBI-11985957;
CC Q8TD17; Q96Q77: CIB3; NbExp=6; IntAct=EBI-8643207, EBI-10292696;
CC Q8TD17; P49760: CLK2; NbExp=6; IntAct=EBI-8643207, EBI-750020;
CC Q8TD17; Q92556: ELMO1; NbExp=5; IntAct=EBI-8643207, EBI-346417;
CC Q8TD17; P50402: EMD; NbExp=3; IntAct=EBI-8643207, EBI-489887;
CC Q8TD17; Q9NWQ4: GPATCH2L; NbExp=5; IntAct=EBI-8643207, EBI-5666657;
CC Q8TD17; Q96A72: MAGOHB; NbExp=6; IntAct=EBI-8643207, EBI-746778;
CC Q8TD17; P55081: MFAP1; NbExp=7; IntAct=EBI-8643207, EBI-1048159;
CC Q8TD17; Q9UBB6: NCDN; NbExp=3; IntAct=EBI-8643207, EBI-1053490;
CC Q8TD17; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-8643207, EBI-10297093;
CC Q8TD17; Q96CV9: OPTN; NbExp=3; IntAct=EBI-8643207, EBI-748974;
CC Q8TD17; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-8643207, EBI-742388;
CC Q8TD17; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-8643207, EBI-725997;
CC Q8TD17; Q6ZMS7: ZNF783; NbExp=4; IntAct=EBI-8643207, EBI-10254978;
CC Q8TD17; Q6ZMS7-2: ZNF783; NbExp=3; IntAct=EBI-8643207, EBI-17789949;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=p71;
CC IsoId=Q8TD17-1; Sequence=Displayed;
CC Name=2; Synonyms=p52;
CC IsoId=Q8TD17-2; Sequence=VSP_006926;
CC -!- INDUCTION: By estrogen receptor alpha.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AY049744; AAK92789.1; -; mRNA.
DR EMBL; AY049743; AAK92788.1; -; mRNA.
DR EMBL; AK290499; BAF83188.1; -; mRNA.
DR EMBL; AK304603; BAG65389.1; -; mRNA.
DR EMBL; AC004890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471146; EAW80057.1; -; Genomic_DNA.
DR EMBL; BC043295; AAH43295.1; -; mRNA.
DR EMBL; AB037760; BAA92577.1; -; mRNA.
DR CCDS; CCDS47739.1; -. [Q8TD17-2]
DR CCDS; CCDS5894.1; -. [Q8TD17-1]
DR RefSeq; NP_065832.1; NM_020781.3. [Q8TD17-2]
DR RefSeq; NP_733787.1; NM_170686.2. [Q8TD17-1]
DR RefSeq; XP_011514743.1; XM_011516441.2. [Q8TD17-2]
DR AlphaFoldDB; Q8TD17; -.
DR SMR; Q8TD17; -.
DR BioGRID; 121600; 40.
DR IntAct; Q8TD17; 27.
DR MINT; Q8TD17; -.
DR STRING; 9606.ENSP00000420418; -.
DR iPTMnet; Q8TD17; -.
DR PhosphoSitePlus; Q8TD17; -.
DR BioMuta; ZNF398; -.
DR DMDM; 23396984; -.
DR EPD; Q8TD17; -.
DR MassIVE; Q8TD17; -.
DR MaxQB; Q8TD17; -.
DR PaxDb; Q8TD17; -.
DR PeptideAtlas; Q8TD17; -.
DR PRIDE; Q8TD17; -.
DR ProteomicsDB; 74217; -. [Q8TD17-1]
DR ProteomicsDB; 74218; -. [Q8TD17-2]
DR Antibodypedia; 18573; 167 antibodies from 23 providers.
DR DNASU; 57541; -.
DR Ensembl; ENST00000426851.6; ENSP00000389972.2; ENSG00000197024.9. [Q8TD17-2]
DR Ensembl; ENST00000475153.6; ENSP00000420418.1; ENSG00000197024.9. [Q8TD17-1]
DR Ensembl; ENST00000483892.5; ENSP00000418564.1; ENSG00000197024.9. [Q8TD17-2]
DR Ensembl; ENST00000491174.1; ENSP00000419391.1; ENSG00000197024.9. [Q8TD17-2]
DR GeneID; 57541; -.
DR KEGG; hsa:57541; -.
DR MANE-Select; ENST00000475153.6; ENSP00000420418.1; NM_170686.3; NP_733787.1.
DR UCSC; uc003wfl.4; human. [Q8TD17-1]
DR CTD; 57541; -.
DR DisGeNET; 57541; -.
DR GeneCards; ZNF398; -.
DR HGNC; HGNC:18373; ZNF398.
DR HPA; ENSG00000197024; Low tissue specificity.
DR MIM; 618593; gene.
DR neXtProt; NX_Q8TD17; -.
DR OpenTargets; ENSG00000197024; -.
DR PharmGKB; PA38532; -.
DR VEuPathDB; HostDB:ENSG00000197024; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161603; -.
DR HOGENOM; CLU_002678_76_3_1; -.
DR InParanoid; Q8TD17; -.
DR OMA; CPKHFPQ; -.
DR PhylomeDB; Q8TD17; -.
DR TreeFam; TF337777; -.
DR PathwayCommons; Q8TD17; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8TD17; -.
DR BioGRID-ORCS; 57541; 16 hits in 1101 CRISPR screens.
DR ChiTaRS; ZNF398; human.
DR GenomeRNAi; 57541; -.
DR Pharos; Q8TD17; Tbio.
DR PRO; PR:Q8TD17; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8TD17; protein.
DR Bgee; ENSG00000197024; Expressed in buccal mucosa cell and 185 other tissues.
DR ExpressionAtlas; Q8TD17; baseline and differential.
DR Genevisible; Q8TD17; HS.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; NAS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR003655; aKRAB.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; DNA-binding; Isopeptide bond;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..642
FT /note="Zinc finger protein 398"
FT /id="PRO_0000047565"
FT DOMAIN 143..214
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 343..364
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 398..420
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 427..449
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 455..477
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 483..505
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 511..533
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 539..561
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 567..590
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 265
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..171
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11779858,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_006926"
FT VARIANT 87
FT /note="E -> D (in dbSNP:rs3801979)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_052817"
FT VARIANT 294
FT /note="S -> L (in dbSNP:rs2240370)"
FT /id="VAR_052818"
SQ SEQUENCE 642 AA; 71311 MW; 69AA38FCD84FF633 CRC64;
MAEAAPAPTS EWDSECLTSL QPLPLPTPPA ANEAHLQTAA ISLWTVVAAV QAIERKVEIH
SRRLLHLEGR TGTAEKKLAS CEKTVTELGN QLEGKWAVLG TLLQEYGLLQ RRLENLENLL
RNRNFWILRL PPGIKGDIPK VPVAFDDVSI YFSTPEWEKL EEWQKELYKN IMKGNYESLI
SMDYAINQPD VLSQIQPEGE HNTEDQAGPE ESEIPTDPSE EPGISTSDIL SWIKQEEEPQ
VGAPPESKES DVYKSTYADE ELVIKAEGLA RSSLCPEVPV PFSSPPAAAK DAFSDVAFKS
QQSTSMTPFG RPATDLPEAS EGQVTFTQLG SYPLPPPVGE QVFSCHHCGK NLSQDMLLTH
QCSHATEHPL PCAQCPKHFT PQADLSSTSQ DHASETPPTC PHCARTFTHP SRLTYHLRVH
NSTERPFPCP DCPKRFADQA RLTSHRRAHA SERPFRCAQC GRSFSLKISL LLHQRGHAQE
RPFSCPQCGI DFNGHSALIR HQMIHTGERP YPCTDCSKSF MRKEHLLNHR RLHTGERPFS
CPHCGKSFIR KHHLMKHQRI HTGERPYPCS YCGRSFRYKQ TLKDHLRSGH NGGCGGDSDP
SGQPPNPPGP LITGLETSGL GVNTEGLETN QWYGEGSGGG VL
