ZN404_HUMAN
ID ZN404_HUMAN Reviewed; 552 AA.
AC Q494X3; A4FU30; K7ELF2;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc finger protein 404;
GN Name=ZNF404;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS TYR-233 AND SER-337.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q494X3; P50222: MEOX2; NbExp=3; IntAct=EBI-10241626, EBI-748397;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC006213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101332; AAI01333.1; -; mRNA.
DR EMBL; BC101333; AAI01334.1; -; mRNA.
DR CCDS; CCDS59394.1; -.
DR RefSeq; NP_001028891.2; NM_001033719.2.
DR AlphaFoldDB; Q494X3; -.
DR SMR; Q494X3; -.
DR BioGRID; 131207; 2.
DR IntAct; Q494X3; 1.
DR STRING; 9606.ENSP00000466051; -.
DR iPTMnet; Q494X3; -.
DR PhosphoSitePlus; Q494X3; -.
DR BioMuta; ZNF404; -.
DR DMDM; 121943242; -.
DR jPOST; Q494X3; -.
DR MassIVE; Q494X3; -.
DR PaxDb; Q494X3; -.
DR PeptideAtlas; Q494X3; -.
DR PRIDE; Q494X3; -.
DR Antibodypedia; 31137; 62 antibodies from 16 providers.
DR DNASU; 342908; -.
DR Ensembl; ENST00000587539.2; ENSP00000466051.1; ENSG00000176222.9.
DR GeneID; 342908; -.
DR KEGG; hsa:342908; -.
DR MANE-Select; ENST00000587539.2; ENSP00000466051.1; NM_001033719.3; NP_001028891.2.
DR UCSC; uc002oxs.7; human.
DR CTD; 342908; -.
DR DisGeNET; 342908; -.
DR GeneCards; ZNF404; -.
DR HGNC; HGNC:19417; ZNF404.
DR HPA; ENSG00000176222; Low tissue specificity.
DR neXtProt; NX_Q494X3; -.
DR OpenTargets; ENSG00000176222; -.
DR PharmGKB; PA134880927; -.
DR VEuPathDB; HostDB:ENSG00000176222; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164159; -.
DR InParanoid; Q494X3; -.
DR OMA; QMIFRKH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q494X3; -.
DR TreeFam; TF350856; -.
DR PathwayCommons; Q494X3; -.
DR SignaLink; Q494X3; -.
DR BioGRID-ORCS; 342908; 31 hits in 1063 CRISPR screens.
DR GenomeRNAi; 342908; -.
DR Pharos; Q494X3; Tdark.
DR PRO; PR:Q494X3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q494X3; protein.
DR Bgee; ENSG00000176222; Expressed in right uterine tube and 128 other tissues.
DR ExpressionAtlas; Q494X3; baseline and differential.
DR Genevisible; Q494X3; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..552
FT /note="Zinc finger protein 404"
FT /id="PRO_0000305136"
FT DOMAIN 6..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 131..153
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 159..181
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 187..209
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 215..237
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 243..265
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..293
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 327..349
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 355..377
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 383..405
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 411..433
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 439..461
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 467..489
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 495..517
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 523..545
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 233
FT /note="H -> Y (in dbSNP:rs12977303)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_057419"
FT VARIANT 337
FT /note="G -> S (in dbSNP:rs239942)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_070605"
SQ SEQUENCE 552 AA; 65425 MW; 9E89530D8E218C30 CRC64;
MARVPLTFSD VAIDFSQEEW EYLNSDQRDL YRDVMLENYT NLVSLDFNFT TESNKLSSEK
RNYEVNAYHQ ETWKRNKTFN LMRFIFRTDP QYTIEFGRQQ RPKVGCFSQM IFKKHKSLPL
HKRNNTREKS YECKEYKKGF RKYLHLTEHL RDHTGVIPYE CNECGKAFVV FQHFIRHRKI
HTDLKPYECN GCEKAFRFYS QLIQHQIIHT GMKPYECKQC GKAFRRHSHL TEHQKIHVGL
KPFECKECGE TFRLYRHMCL HQKIHHGVKP YKCKECGKAF GHRSSLYQHK KIHSGEKPYK
CEQCEKAFVR SYLLVEHQRS HTGEKPHECM ECGKAFGKGS SLLKHKRIHS SEKLYDCKDC
GKAFCRGSQL TQHQRIHTGE KPHECKECGK TFKLHSYLIQ HQIIHTDLKP YECKQCGKAF
SRVGDLKTHQ SIHAGEKPYE CKECGKTFRL NSQLIYHQTI HTGLKPYVCK ECKKAFRSIS
GLSQHKRIHT GEKPYECKEC DKAFNRSDRL TQHETIHTGV KPQKCKECGK AFSHCYQLSQ
HQRFHHGERL LM
