ZN407_HUMAN
ID ZN407_HUMAN Reviewed; 2248 AA.
AC Q9C0G0; B5MD54; Q96MY0; Q9H8A1; Q9NXD4; Q9NXD7;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Zinc finger protein 407;
GN Name=ZNF407; Synonyms=KIAA1703;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-784 AND 1998-2248 (ISOFORM 1),
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 774-2248 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1124-2248 (ISOFORM 3).
RC TISSUE=Hepatoma, Teratocarcinoma, and Thyroid;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1084-2248 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1262, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1262, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [7]
RP INVOLVEMENT IN SIMHA, AND VARIANT SIMHA TRP-1685.
RX PubMed=24907849; DOI=10.1186/1750-1172-9-80;
RA Kambouris M., Maroun R.C., Ben-Omran T., Al-Sarraj Y., Errafii K., Ali R.,
RA Boulos H., Curmi P.A., El-Shanti H.;
RT "Mutations in zinc finger 407 [ZNF407] cause a unique autosomal recessive
RT cognitive impairment syndrome.";
RL Orphanet J. Rare Dis. 9:80-80(2014).
RN [8]
RP VARIANTS SIMHA VAL-802; VAL-939 INS; GLY-962 AND ASN-1214.
RX PubMed=32737394; DOI=10.1038/s10038-020-0812-0;
RA Zahra Q., Cakmak C., Koprulu M., Shuaib M., Sobreira N., Kalsner L.,
RA Sobreira J., Guillen Sacoto M.J., Malik S., Tolun A.;
RT "Biallelic ZNF407 mutations in a neurodevelopmental disorder with ID, short
RT stature and variable microcephaly, hypotonia, ocular anomalies and facial
RT dysmorphism.";
RL J. Hum. Genet. 65:1115-1123(2020).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9C0G0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C0G0-2; Sequence=VSP_028845, VSP_028846;
CC Name=3;
CC IsoId=Q9C0G0-3; Sequence=VSP_028843, VSP_028844;
CC -!- DISEASE: Short stature, impaired intellectual development,
CC microcephaly, hypotonia, and ocular anomalies (SIMHA) [MIM:619557]: An
CC autosomal recessive syndrome characterized by short stature, impaired
CC intellectual development, microcephaly, hypotonia, and ocular
CC anomalies. {ECO:0000269|PubMed:24907849, ECO:0000269|PubMed:32737394}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91077.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA91080.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC138660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC091589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC023380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC100783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC015819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK000314; BAA91077.1; ALT_INIT; mRNA.
DR EMBL; AK000317; BAA91080.1; ALT_INIT; mRNA.
DR EMBL; AK023901; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK056288; BAB71139.1; -; mRNA.
DR EMBL; AB051490; BAB21794.1; -; mRNA.
DR CCDS; CCDS45885.1; -. [Q9C0G0-1]
DR CCDS; CCDS54191.1; -. [Q9C0G0-3]
DR CCDS; CCDS58634.1; -. [Q9C0G0-2]
DR RefSeq; NP_001139661.1; NM_001146189.1. [Q9C0G0-2]
DR RefSeq; NP_001139662.1; NM_001146190.1. [Q9C0G0-3]
DR RefSeq; NP_060227.2; NM_017757.2. [Q9C0G0-1]
DR RefSeq; XP_005266783.1; XM_005266726.4.
DR RefSeq; XP_011524370.1; XM_011526068.2.
DR RefSeq; XP_011524372.1; XM_011526070.1. [Q9C0G0-3]
DR AlphaFoldDB; Q9C0G0; -.
DR BioGRID; 120767; 11.
DR IntAct; Q9C0G0; 6.
DR STRING; 9606.ENSP00000299687; -.
DR iPTMnet; Q9C0G0; -.
DR PhosphoSitePlus; Q9C0G0; -.
DR BioMuta; ZNF407; -.
DR DMDM; 160358927; -.
DR EPD; Q9C0G0; -.
DR jPOST; Q9C0G0; -.
DR MassIVE; Q9C0G0; -.
DR MaxQB; Q9C0G0; -.
DR PaxDb; Q9C0G0; -.
DR PeptideAtlas; Q9C0G0; -.
DR PRIDE; Q9C0G0; -.
DR ProteomicsDB; 80031; -. [Q9C0G0-1]
DR ProteomicsDB; 80032; -. [Q9C0G0-2]
DR ProteomicsDB; 80033; -. [Q9C0G0-3]
DR Antibodypedia; 23353; 51 antibodies from 13 providers.
DR DNASU; 55628; -.
DR Ensembl; ENST00000299687.10; ENSP00000299687.4; ENSG00000215421.10. [Q9C0G0-1]
DR Ensembl; ENST00000309902.10; ENSP00000310359.5; ENSG00000215421.10. [Q9C0G0-3]
DR Ensembl; ENST00000577538.5; ENSP00000463270.1; ENSG00000215421.10. [Q9C0G0-2]
DR Ensembl; ENST00000582337.5; ENSP00000462348.1; ENSG00000215421.10. [Q9C0G0-3]
DR GeneID; 55628; -.
DR KEGG; hsa:55628; -.
DR MANE-Select; ENST00000299687.10; ENSP00000299687.4; NM_017757.3; NP_060227.2.
DR UCSC; uc002llw.3; human. [Q9C0G0-1]
DR CTD; 55628; -.
DR DisGeNET; 55628; -.
DR GeneCards; ZNF407; -.
DR HGNC; HGNC:19904; ZNF407.
DR HPA; ENSG00000215421; Low tissue specificity.
DR MIM; 615894; gene.
DR MIM; 619557; phenotype.
DR neXtProt; NX_Q9C0G0; -.
DR OpenTargets; ENSG00000215421; -.
DR PharmGKB; PA134942906; -.
DR VEuPathDB; HostDB:ENSG00000215421; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156446; -.
DR HOGENOM; CLU_002134_0_0_1; -.
DR InParanoid; Q9C0G0; -.
DR OMA; DNKCLHC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9C0G0; -.
DR TreeFam; TF350895; -.
DR PathwayCommons; Q9C0G0; -.
DR SignaLink; Q9C0G0; -.
DR BioGRID-ORCS; 55628; 634 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF407; human.
DR GenomeRNAi; 55628; -.
DR Pharos; Q9C0G0; Tbio.
DR PRO; PR:Q9C0G0; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q9C0G0; protein.
DR Bgee; ENSG00000215421; Expressed in secondary oocyte and 183 other tissues.
DR ExpressionAtlas; Q9C0G0; baseline and differential.
DR Genevisible; Q9C0G0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 25.
DR SMART; SM00451; ZnF_U1; 7.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW Alternative splicing; Disease variant; DNA-binding; Dwarfism;
KW Intellectual disability; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..2248
FT /note="Zinc finger protein 407"
FT /id="PRO_0000047568"
FT ZN_FING 186..208
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 215..238
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 244..268
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 528..551
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 557..581
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 615..639
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 705..728
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 850..873
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 879..903
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1017..1040
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1046..1070
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1444..1468
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1486..1509
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1537..1561
FT /note="C2H2-type 14; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1567..1589
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1595..1618
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1628..1650
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1656..1680
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1686..1708
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1714..1736
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1742..1767
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1773..1796
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1262
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT VAR_SEQ 1625..1660
FT /note="ERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTW -> ERVKVAYRKIGT
FT LPGIQNNRNASSASEAQSLCEHFS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028843"
FT VAR_SEQ 1661..2248
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028844"
FT VAR_SEQ 1811..1815
FT /note="IVSKS -> KGQKL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028845"
FT VAR_SEQ 1816..2248
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028846"
FT VARIANT 69
FT /note="N -> S (in dbSNP:rs3794942)"
FT /id="VAR_052820"
FT VARIANT 512
FT /note="G -> R (in dbSNP:rs7227263)"
FT /id="VAR_052821"
FT VARIANT 802
FT /note="G -> V (in SIMHA; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:32737394"
FT /id="VAR_086433"
FT VARIANT 939
FT /note="V -> VV (in SIMHA)"
FT /evidence="ECO:0000269|PubMed:32737394"
FT /id="VAR_086434"
FT VARIANT 962
FT /note="R -> G (in SIMHA; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:32737394"
FT /id="VAR_086435"
FT VARIANT 972
FT /note="N -> T (in dbSNP:rs948615)"
FT /id="VAR_036694"
FT VARIANT 1214
FT /note="K -> N (in SIMHA; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:32737394"
FT /id="VAR_086436"
FT VARIANT 1259
FT /note="S -> L (in dbSNP:rs34048449)"
FT /id="VAR_061945"
FT VARIANT 1685
FT /note="S -> W (in SIMHA)"
FT /evidence="ECO:0000269|PubMed:24907849"
FT /id="VAR_086437"
FT VARIANT 1913
FT /note="A -> T (in dbSNP:rs17056248)"
FT /id="VAR_052822"
FT CONFLICT 988
FT /note="K -> E (in Ref. 2; BAA91077)"
FT /evidence="ECO:0000305"
FT CONFLICT 1297
FT /note="V -> D (in Ref. 2; BAA91077)"
FT /evidence="ECO:0000305"
FT CONFLICT 1353
FT /note="F -> S (in Ref. 2; BAA91077)"
FT /evidence="ECO:0000305"
FT CONFLICT 1415
FT /note="R -> C (in Ref. 2; BAA91077)"
FT /evidence="ECO:0000305"
FT CONFLICT 1520
FT /note="I -> V (in Ref. 2; BAA91077)"
FT /evidence="ECO:0000305"
FT CONFLICT 1584
FT /note="N -> D (in Ref. 2; BAA91080)"
FT /evidence="ECO:0000305"
FT CONFLICT 2181
FT /note="D -> G (in Ref. 2; AK023901)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2248 AA; 247367 MW; 1AE958917F5F7B91 CRC64;
MMDSENKPEN DEDEKINKEA QDLTKLSSHN EDGGPVSDVI ASFPENSMGK RGFSESSNSD
SVVIGEDRNK HASKRRKLDE AEPLKSGKQG ICRLETSESS VTEGGIALDE TGKETFLSDC
TVGGTCLPNA LSPSCNFSTI DVVSLKTDTE KTSAQEMVSL DLERESPFPP KEISVSCTIG
NVDTVLKCSI CGHLFSSCSD LEKHAESHMQ QPKEHTCCHC SHKAESSSAL HMHIKQAHGP
QKVFSCDLCG FQCSEENLLN AHYLGKTHLR RQNLAARGGF VQILTKQPFP KKSRTMATKN
VHSKPRTSKS IAKNSDSKGL RNVGSTFKDF RGSISKQSGS SSELLVEMMP SRNTLSQEVE
IVEEHVTSLG LAQNPENQSR KLDTLVTSEG LLEKLESTKN TLQAAHGNSV TSRPRPERNI
LVLGNSFRRR SSTFTLKGQA KKRFNLLGIK RGTSETQRMY MKHLRTQMKT HDAESVLKHL
EACSSVQRVC VTTSETQEAE QGQGSARPPD SGLHSLTVKP ASGSQTLCAC TDCGQVATNR
TDLEIHVKRC HAREMKFYCR TCDFSSMSRR DLDEHLHSNQ HQQTASVLSC QCCSFISLDE
INLRDHMKEK HNMHFLCTPC NLFFLSEKDV EEHKATEKHI NSLVQPKTLQ SSNSDLVLQT
LPLSTLESEN AKESMDDSGK ASQEEPLKSR VSHGNEVRHS SKPQFQCKKC FYKTRSSTVL
TRHIKLRHGQ DYHFLCKACN LYSLSKEGME KHIKRSKHLE NAKKNNIGLS FEECIERVCI
GANDKKEEFD VSGNGRIEGH IGVQLQEHSY LEKGMLASEE LSQSGGSTKD DELASTTTPK
RGRPKGNISR TCSHCGLLAS SITNLTVHIR RKHSHQYSYL CKVCKYYTVT KGDMERHCAT
KKHKGRVEIE ASGKHSSDII VGPEGGSLEA GKKNAGSAVT MSDEHANKPA ESPTSVLEKP
DRGNSIEAEV ENVFHSLDGE VNSHLLDKKE QISSEPEDFA QPGDVYSQRD VTGTGENKCL
HCEFSAHSSA SLELHVKRKH TKEFEFYCMA CDYYAVTRRE MTRHAATEKH KMKRQSYLNS
ANVEAGSADM SKNIIMPEEE HQQNSEEFQI ISGQPSDTLK SRNAADCSIL NENTNLDMSK
VLCAADSVEV ETEEESNFNE DHSFCETFQQ APVKDKVRKP EEMMSLTMSS NYGSPSRFQN
ENSGSSALNC ETAKKNHEIS NDAGELRVHC EGEGGNAGDG GGVVPHRHLC PVTLDGERSA
ESPVLVVTRI TREQGNLESG GQNRVARGHG LEDLKGVQED PVLGNKEILM NSQHETEFIL
EEDGPASDST VESSDVYETI ISIDDKGQAM YSFGRFDSSI IRIKNPEDGE LIDQSEEGLI
ATGVRISELP LKDCAQGVKK KKSEGSSIGE STRIRCDDCG FLADGLSGLN VHIAMKHPTK
EKHFHCLLCG KSFYTESNLH QHLASAGHMR NEQASVEELP EGGATFKCVK CTEPFDSEQN
LFLHIKGQHE ELLREVNKYI VEDTEQINRE REENQGNVCK YCGKMCRSSN SMAFLAHIRT
HTGSKPFKCK ICHFATAQLG DARNHVKRHL GMREYKCHVC GVAFVMKKHL NTHLLGKHGV
GTPKERKFTC HLCDRSFTEK WALNNHMKLH TGEKPFKCTW PTCHYSFLTA SAMKDHYRTH
TGEKSFLCDL CGFAGGTRHA LTKHRRQHTG EKPFKCDECN FASTTQSHLT RHKRVHTGEK
PYRCPWCDYR SNCAENIRKH ILHTGKHEGV KMYNCPKCDY GTNVPVEFRN HLKEQHPDIE
NPDLAYLHAG IVSKSYECRL KGQGATFVET DSPFTAAALA EEPLVKEKPL RSSRRPAPPP
EQVQQVIIFQ GYDGEFALDP SVEETAAATL QTLAMAGQVA RVVHITEDGQ VIATSQSGAH
VGSVVPGPIL PEQLADGATQ VVVVGGSMEG HGMDESLSPG GAVIQQVTKQ EILNLSEAGV
APPEASSALD ALLCAVTELG EVEGRAGLEE QGRPGAKDVL IQLPGQEVSH VAADPEAPEI
QMFPQAQESP AAVEVLTQVV HPSAAMASQE RAQVAFKKMV QGVLQFAVCD TAAAGQLVKD
GVTQVVVSEE GAVHMVAGEG AQIIMQEAQG EHMDLVESDG EISQIIVTEE LVQAMVQESS
GGFSEGTTHY ILTELPPGVQ DEPGLYSHTV LETADSQELL QAGATLGTEA GAPSRAEQLA
SVVIYTQEGS SAAAAIQSQR ESSELQEA
