ZN414_HUMAN
ID ZN414_HUMAN Reviewed; 312 AA.
AC Q96IQ9; A8MY94;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Zinc finger protein 414;
GN Name=ZNF414;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT SER-77.
RC TISSUE=Adipose tissue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-65.
RC TISSUE=Eye, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96IQ9; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-744257, EBI-10173507;
CC Q96IQ9; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-744257, EBI-739580;
CC Q96IQ9; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-744257, EBI-3866279;
CC Q96IQ9; P27918: CFP; NbExp=3; IntAct=EBI-744257, EBI-9038570;
CC Q96IQ9; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-744257, EBI-12819063;
CC Q96IQ9; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-744257, EBI-3867333;
CC Q96IQ9; P98095: FBLN2; NbExp=3; IntAct=EBI-744257, EBI-947973;
CC Q96IQ9; Q08379: GOLGA2; NbExp=7; IntAct=EBI-744257, EBI-618309;
CC Q96IQ9; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-744257, EBI-5916454;
CC Q96IQ9; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-744257, EBI-748420;
CC Q96IQ9; Q6UXX5: ITIH6; NbExp=3; IntAct=EBI-744257, EBI-11028396;
CC Q96IQ9; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-744257, EBI-2556193;
CC Q96IQ9; Q15323: KRT31; NbExp=3; IntAct=EBI-744257, EBI-948001;
CC Q96IQ9; O76011: KRT34; NbExp=3; IntAct=EBI-744257, EBI-1047093;
CC Q96IQ9; O76013-2: KRT36; NbExp=3; IntAct=EBI-744257, EBI-11958506;
CC Q96IQ9; O43790: KRT86; NbExp=3; IntAct=EBI-744257, EBI-9996498;
CC Q96IQ9; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-744257, EBI-11749135;
CC Q96IQ9; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-744257, EBI-10172290;
CC Q96IQ9; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-744257, EBI-10171774;
CC Q96IQ9; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-744257, EBI-10241252;
CC Q96IQ9; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-744257, EBI-12811111;
CC Q96IQ9; Q3LI72: KRTAP19-5; NbExp=5; IntAct=EBI-744257, EBI-1048945;
CC Q96IQ9; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-744257, EBI-12805508;
CC Q96IQ9; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-744257, EBI-9996449;
CC Q96IQ9; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-744257, EBI-739863;
CC Q96IQ9; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-744257, EBI-3958099;
CC Q96IQ9; Q3LI64: KRTAP6-1; NbExp=5; IntAct=EBI-744257, EBI-12111050;
CC Q96IQ9; Q3LI66: KRTAP6-2; NbExp=5; IntAct=EBI-744257, EBI-11962084;
CC Q96IQ9; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-744257, EBI-1043191;
CC Q96IQ9; Q99750: MDFI; NbExp=3; IntAct=EBI-744257, EBI-724076;
CC Q96IQ9; Q13064: MKRN3; NbExp=3; IntAct=EBI-744257, EBI-2340269;
CC Q96IQ9; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-744257, EBI-11522433;
CC Q96IQ9; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-744257, EBI-22310682;
CC Q96IQ9; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-744257, EBI-9640281;
CC Q96IQ9; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-744257, EBI-79165;
CC Q96IQ9; Q16633: POU2AF1; NbExp=3; IntAct=EBI-744257, EBI-943588;
CC Q96IQ9; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-744257, EBI-710402;
CC Q96IQ9; Q9BYM8: RBCK1; NbExp=3; IntAct=EBI-744257, EBI-2340624;
CC Q96IQ9; P57052: RBM11; NbExp=3; IntAct=EBI-744257, EBI-741332;
CC Q96IQ9; O14492-2: SH2B2; NbExp=3; IntAct=EBI-744257, EBI-19952306;
CC Q96IQ9; O60504: SORBS3; NbExp=3; IntAct=EBI-744257, EBI-741237;
CC Q96IQ9; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-744257, EBI-5235340;
CC Q96IQ9; Q7Z698: SPRED2; NbExp=3; IntAct=EBI-744257, EBI-7082156;
CC Q96IQ9; Q9NYB0: TERF2IP; NbExp=2; IntAct=EBI-744257, EBI-750109;
CC Q96IQ9; Q8IYF3-3: TEX11; NbExp=3; IntAct=EBI-744257, EBI-11523345;
CC Q96IQ9; Q08117-2: TLE5; NbExp=5; IntAct=EBI-744257, EBI-11741437;
CC Q96IQ9; Q9UDY6-2: TRIM10; NbExp=3; IntAct=EBI-744257, EBI-11981577;
CC Q96IQ9; P14373: TRIM27; NbExp=3; IntAct=EBI-744257, EBI-719493;
CC Q96IQ9; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-744257, EBI-5235829;
CC Q96IQ9; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-744257, EBI-12040603;
CC Q96IQ9; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-744257, EBI-12030590;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96IQ9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96IQ9-2; Sequence=VSP_045351;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK074191; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC092298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471139; EAW68915.1; -; Genomic_DNA.
DR EMBL; BC007310; AAH07310.1; -; mRNA.
DR EMBL; BC071937; AAH71937.1; -; mRNA.
DR CCDS; CCDS12205.1; -. [Q96IQ9-1]
DR CCDS; CCDS54211.1; -. [Q96IQ9-2]
DR RefSeq; NP_001139647.1; NM_001146175.1. [Q96IQ9-2]
DR RefSeq; NP_115746.2; NM_032370.2. [Q96IQ9-1]
DR AlphaFoldDB; Q96IQ9; -.
DR BioGRID; 124054; 119.
DR IntAct; Q96IQ9; 84.
DR STRING; 9606.ENSP00000377504; -.
DR GlyGen; Q96IQ9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96IQ9; -.
DR PhosphoSitePlus; Q96IQ9; -.
DR BioMuta; ZNF414; -.
DR DMDM; 125987870; -.
DR EPD; Q96IQ9; -.
DR jPOST; Q96IQ9; -.
DR MassIVE; Q96IQ9; -.
DR MaxQB; Q96IQ9; -.
DR PaxDb; Q96IQ9; -.
DR PeptideAtlas; Q96IQ9; -.
DR PRIDE; Q96IQ9; -.
DR ProteomicsDB; 2385; -.
DR ProteomicsDB; 76845; -. [Q96IQ9-1]
DR Antibodypedia; 24915; 45 antibodies from 15 providers.
DR DNASU; 84330; -.
DR Ensembl; ENST00000255616.8; ENSP00000255616.7; ENSG00000133250.14. [Q96IQ9-1]
DR Ensembl; ENST00000393927.9; ENSP00000377504.3; ENSG00000133250.14. [Q96IQ9-2]
DR GeneID; 84330; -.
DR KEGG; hsa:84330; -.
DR MANE-Select; ENST00000393927.9; ENSP00000377504.3; NM_001146175.2; NP_001139647.1. [Q96IQ9-2]
DR UCSC; uc002mke.5; human. [Q96IQ9-1]
DR CTD; 84330; -.
DR DisGeNET; 84330; -.
DR GeneCards; ZNF414; -.
DR HGNC; HGNC:20630; ZNF414.
DR HPA; ENSG00000133250; Low tissue specificity.
DR neXtProt; NX_Q96IQ9; -.
DR OpenTargets; ENSG00000133250; -.
DR PharmGKB; PA142670521; -.
DR VEuPathDB; HostDB:ENSG00000133250; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00390000006876; -.
DR HOGENOM; CLU_049178_0_0_1; -.
DR InParanoid; Q96IQ9; -.
DR OMA; CSRRILW; -.
DR OrthoDB; 943003at2759; -.
DR PhylomeDB; Q96IQ9; -.
DR TreeFam; TF337512; -.
DR PathwayCommons; Q96IQ9; -.
DR SignaLink; Q96IQ9; -.
DR BioGRID-ORCS; 84330; 14 hits in 1103 CRISPR screens.
DR ChiTaRS; ZNF414; human.
DR GenomeRNAi; 84330; -.
DR Pharos; Q96IQ9; Tdark.
DR PRO; PR:Q96IQ9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96IQ9; protein.
DR Bgee; ENSG00000133250; Expressed in granulocyte and 91 other tissues.
DR ExpressionAtlas; Q96IQ9; baseline and differential.
DR Genevisible; Q96IQ9; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR039882; ZN414.
DR InterPro; IPR031799; Znf-C2H2_ribbon.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR21695; PTHR21695; 1.
DR Pfam; PF15909; zf-C2H2_8; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..312
FT /note="Zinc finger protein 414"
FT /id="PRO_0000242163"
FT ZN_FING 109..133
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 145..169
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 176..201
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..266
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 310..312
FT /note="ACR -> HAAPSRIVWEHTRGRYSCMQCAFSTASRPAMTLHLEDHRPGAPAA
FT PAAGPPRPDAPADPAPLAPKVSPLLSEGELPVFSQL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045351"
FT VARIANT 65
FT /note="Q -> R (in dbSNP:rs8100431)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026847"
FT VARIANT 77
FT /note="P -> S (in dbSNP:rs1064010)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_026848"
FT CONFLICT Q96IQ9-2:357
FT /note="A -> P (in Ref. 1; AK074191)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 32782 MW; B3DFB0C66CD09796 CRC64;
MEEKPSGPIP DMLATAEPSS SETDKEVLSP AVPAAAPSSS MSEEPGPEQA ATPPVWERGG
AGGMQQGSSP APDSCQPGPG PSPGLTSIVS GTSEDLRPPR RRPPPGKQIP CSSPGCCLSF
PSVRDLAQHL RTHCPPTQSL EGKLFRCSAL SCTETFPSMQ ELVAHSKLHY KPNRYFKCEN
CLLRFRTHRS LFKHLHVCAE HAQSPAPPPP PALDREPPAP ERPPEVDPAS APGLPFPLLE
PFTTPAPAPT GPFLPYLNPA PFGLSPPRLR PFLAAAPGPP ASSAAVWKKS QGAGSSPRRP
QGGSDAPSGA CR
