ZN414_MOUSE
ID ZN414_MOUSE Reviewed; 299 AA.
AC Q9DCK4; Q8CHU9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Zinc finger protein 414;
GN Name=Znf414; Synonyms=Zfp414;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Dendritic cell, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=15112104; DOI=10.1007/s00335-003-2329-1;
RA Abe K., Yuzuriha M., Sugimoto M., Ko M.S., Brathwaite M.E., Waeltz P.,
RA Nagaraja R.;
RT "Gene content of the 750-kb critical region for mouse embryonic ectoderm
RT lethal tcl-w5.";
RL Mamm. Genome 15:265-276(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9DCK4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DCK4-2; Sequence=VSP_019454;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK002706; BAB22300.1; -; mRNA.
DR EMBL; AK169869; BAE41424.1; -; mRNA.
DR EMBL; AF528163; AAO17381.1; -; Genomic_DNA.
DR EMBL; BC038913; AAH38913.1; -; mRNA.
DR CCDS; CCDS37568.1; -. [Q9DCK4-1]
DR RefSeq; NP_080988.1; NM_026712.3. [Q9DCK4-1]
DR AlphaFoldDB; Q9DCK4; -.
DR STRING; 10090.ENSMUSP00000073259; -.
DR PhosphoSitePlus; Q9DCK4; -.
DR MaxQB; Q9DCK4; -.
DR PaxDb; Q9DCK4; -.
DR PRIDE; Q9DCK4; -.
DR ProteomicsDB; 275011; -. [Q9DCK4-1]
DR ProteomicsDB; 275012; -. [Q9DCK4-2]
DR Antibodypedia; 24915; 45 antibodies from 15 providers.
DR Ensembl; ENSMUST00000073570; ENSMUSP00000073259; ENSMUSG00000073423. [Q9DCK4-1]
DR Ensembl; ENSMUST00000166627; ENSMUSP00000129423; ENSMUSG00000073423. [Q9DCK4-2]
DR GeneID; 328801; -.
DR KEGG; mmu:328801; -.
DR UCSC; uc008byw.2; mouse. [Q9DCK4-1]
DR CTD; 328801; -.
DR MGI; MGI:1915641; Zfp414.
DR VEuPathDB; HostDB:ENSMUSG00000073423; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00390000006876; -.
DR HOGENOM; CLU_049178_0_0_1; -.
DR InParanoid; Q9DCK4; -.
DR OMA; CSRRILW; -.
DR PhylomeDB; Q9DCK4; -.
DR TreeFam; TF337512; -.
DR BioGRID-ORCS; 328801; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Zfp414; mouse.
DR PRO; PR:Q9DCK4; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9DCK4; protein.
DR Bgee; ENSMUSG00000073423; Expressed in granulocyte and 221 other tissues.
DR ExpressionAtlas; Q9DCK4; baseline and differential.
DR Genevisible; Q9DCK4; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR039882; ZN414.
DR InterPro; IPR031799; Znf-C2H2_ribbon.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR21695; PTHR21695; 1.
DR Pfam; PF15909; zf-C2H2_8; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..299
FT /note="Zinc finger protein 414"
FT /id="PRO_0000242164"
FT ZN_FING 99..123
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 135..159
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 166..190
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..207
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..49
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_019454"
SQ SEQUENCE 299 AA; 31988 MW; D68D58D7D28C5DDB CRC64;
MEEPSRPSSD TLTTVESSSG EPDKEVASPD GAAPATFSSV EEPSPNPTAM PPVWDHGGPL
QQVAYPASDS CQTGSTNTGV GTNEDLRLPR RRPPPGKQIP CSSPGCCLSF PSVRDLAQHL
RTHCPPTQSL EGKLFRCSAL SCTESFPSMQ ELVAHGKLHY KPNRYFKCEN CLLRFRTHRS
LFKHLHVCID HGQNPAPPPP PALDKEPPVP ERPPESDPSS SLGLPFPLLE PFTSAPTGPF
LPYLNPAPFG LSPPRLRPFL AATPGPPASS TAIWKKSQGA TSSPRRPQGG SDAPSGACR
