ZN415_HUMAN
ID ZN415_HUMAN Reviewed; 603 AA.
AC Q09FC8; F5H287; Q09FC7; Q09FC9; Q09FD0; Q6NSZ2; Q6P3S0; Q9NUR2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Zinc finger protein 415;
GN Name=ZNF415;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), FUNCTION,
RP SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, AND
RP VARIANTS LEU-229 AND VAL-233.
RC TISSUE=Fetal heart;
RX PubMed=17055453; DOI=10.1016/j.bbrc.2006.09.161;
RA Cheng Y., Wang Y., Li Y., Deng Y., Hu J., Mo X., Li N., Li Y., Luo N.,
RA Yuan W., Xiao J., Zhu C., Wu X., Liu M.;
RT "A novel human gene ZNF415 with five isoforms inhibits AP-1- and p53-
RT mediated transcriptional activity.";
RL Biochem. Biophys. Res. Commun. 351:33-39(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-72 (ISOFORM 6), AND VARIANTS LEU-229 AND VAL-233.
RC TISSUE=Brain, Placenta, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANT ASP-463.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in transcriptional regulation. Transcriptional
CC activity differed among the various isoforms. All isoforms except
CC isoform 3 seem to suppresses the transcriptional activities of AP-1 and
CC p53/TP53. {ECO:0000269|PubMed:17055453}.
CC -!- INTERACTION:
CC Q09FC8; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-10226171, EBI-739863;
CC Q09FC8; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10226171, EBI-742948;
CC Q09FC8-4; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-12273744, EBI-3866279;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17055453}. Cytoplasm
CC {ECO:0000269|PubMed:17055453}. Note=Isoforms 1, isoform 2, isoform 4
CC and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3
CC localized only to nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1; Synonyms=ZNF415-3;
CC IsoId=Q09FC8-1; Sequence=Displayed;
CC Name=2; Synonyms=ZNF415-2;
CC IsoId=Q09FC8-2; Sequence=VSP_025178;
CC Name=3; Synonyms=ZNF415-1;
CC IsoId=Q09FC8-3; Sequence=VSP_025175;
CC Name=4; Synonyms=ZNF415-4;
CC IsoId=Q09FC8-4; Sequence=VSP_025177;
CC Name=5; Synonyms=ZNF415-5;
CC IsoId=Q09FC8-5; Sequence=VSP_025176;
CC Name=6;
CC IsoId=Q09FC8-6; Sequence=VSP_044807;
CC -!- TISSUE SPECIFICITY: Expressed in all tissues examined. Isoforms are
CC differentially expressed. Isoform 3 and isoform 5 were highly
CC expressed, isoform 4 moderately expressed, isoform 2 lower expression,
CC the lowest expression level was seem with isoform 1.
CC {ECO:0000269|PubMed:17055453}.
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DR EMBL; DQ925697; ABI51311.1; -; mRNA.
DR EMBL; DQ925696; ABI51310.1; -; mRNA.
DR EMBL; DQ925698; ABI51312.1; -; mRNA.
DR EMBL; DQ925695; ABI51309.1; -; mRNA.
DR EMBL; AY283600; AAP35086.1; -; mRNA.
DR EMBL; AK002053; BAA92059.1; -; mRNA.
DR EMBL; DA518713; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC010328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069668; AAH69668.1; -; mRNA.
DR EMBL; BC063880; AAH63880.1; -; mRNA.
DR CCDS; CCDS12860.1; -. [Q09FC8-5]
DR CCDS; CCDS54313.1; -. [Q09FC8-6]
DR CCDS; CCDS82393.1; -. [Q09FC8-3]
DR RefSeq; NP_001129510.2; NM_001136038.2. [Q09FC8-6]
DR RefSeq; NP_001157781.1; NM_001164309.1. [Q09FC8-5]
DR RefSeq; NP_001317688.1; NM_001330759.1. [Q09FC8-3]
DR RefSeq; NP_001317695.1; NM_001330766.1.
DR RefSeq; NP_060825.2; NM_018355.3. [Q09FC8-5]
DR RefSeq; XP_006723335.1; XM_006723272.2.
DR RefSeq; XP_006723336.1; XM_006723273.2.
DR RefSeq; XP_006723337.1; XM_006723274.2.
DR RefSeq; XP_006723340.1; XM_006723277.2.
DR RefSeq; XP_006723342.1; XM_006723279.1. [Q09FC8-4]
DR RefSeq; XP_006723343.1; XM_006723280.2. [Q09FC8-3]
DR RefSeq; XP_006723344.1; XM_006723281.2.
DR RefSeq; XP_011525405.1; XM_011527103.1.
DR RefSeq; XP_011525406.1; XM_011527104.1.
DR RefSeq; XP_016882453.1; XM_017026964.1. [Q09FC8-5]
DR RefSeq; XP_016882454.1; XM_017026965.1.
DR RefSeq; XP_016882455.1; XM_017026966.1.
DR RefSeq; XP_016882456.1; XM_017026967.1.
DR RefSeq; XP_016882457.1; XM_017026968.1. [Q09FC8-4]
DR RefSeq; XP_016882459.1; XM_017026970.1. [Q09FC8-2]
DR RefSeq; XP_016882461.1; XM_017026972.1.
DR RefSeq; XP_016882462.1; XM_017026973.1.
DR AlphaFoldDB; Q09FC8; -.
DR SMR; Q09FC8; -.
DR BioGRID; 120900; 7.
DR IntAct; Q09FC8; 4.
DR STRING; 9606.ENSP00000439435; -.
DR iPTMnet; Q09FC8; -.
DR PhosphoSitePlus; Q09FC8; -.
DR BioMuta; ZNF415; -.
DR DMDM; 147742905; -.
DR jPOST; Q09FC8; -.
DR MassIVE; Q09FC8; -.
DR MaxQB; Q09FC8; -.
DR PaxDb; Q09FC8; -.
DR PeptideAtlas; Q09FC8; -.
DR PRIDE; Q09FC8; -.
DR ProteomicsDB; 25895; -.
DR ProteomicsDB; 58725; -. [Q09FC8-1]
DR ProteomicsDB; 58726; -. [Q09FC8-2]
DR ProteomicsDB; 58727; -. [Q09FC8-3]
DR ProteomicsDB; 58728; -. [Q09FC8-4]
DR ProteomicsDB; 58729; -. [Q09FC8-5]
DR Antibodypedia; 820; 140 antibodies from 21 providers.
DR DNASU; 55786; -.
DR Ensembl; ENST00000243643.9; ENSP00000243643.3; ENSG00000170954.12. [Q09FC8-5]
DR Ensembl; ENST00000421033.5; ENSP00000395055.2; ENSG00000170954.12. [Q09FC8-5]
DR Ensembl; ENST00000500065.8; ENSP00000439435.1; ENSG00000170954.12. [Q09FC8-6]
DR Ensembl; ENST00000601493.5; ENSP00000472911.1; ENSG00000170954.12. [Q09FC8-3]
DR GeneID; 55786; -.
DR KEGG; hsa:55786; -.
DR MANE-Select; ENST00000243643.9; ENSP00000243643.3; NM_018355.4; NP_060825.2. [Q09FC8-5]
DR UCSC; uc002qaw.4; human. [Q09FC8-1]
DR CTD; 55786; -.
DR DisGeNET; 55786; -.
DR GeneCards; ZNF415; -.
DR HGNC; HGNC:20636; ZNF415.
DR HPA; ENSG00000170954; Low tissue specificity.
DR MIM; 619506; gene.
DR neXtProt; NX_Q09FC8; -.
DR OpenTargets; ENSG00000170954; -.
DR PharmGKB; PA134984602; -.
DR VEuPathDB; HostDB:ENSG00000170954; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164638; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q09FC8; -.
DR OMA; HCSNFNR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q09FC8; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q09FC8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q09FC8; -.
DR BioGRID-ORCS; 55786; 11 hits in 1092 CRISPR screens.
DR ChiTaRS; ZNF415; human.
DR GenomeRNAi; 55786; -.
DR Pharos; Q09FC8; Tdark.
DR PRO; PR:Q09FC8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q09FC8; protein.
DR Bgee; ENSG00000170954; Expressed in sperm and 175 other tissues.
DR ExpressionAtlas; Q09FC8; baseline and differential.
DR Genevisible; Q09FC8; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001650; C:fibrillar center; IDA:HPA.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..603
FT /note="Zinc finger protein 415"
FT /id="PRO_0000286808"
FT ZN_FING 264..286
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 292..314
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..342
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 348..370
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 376..398
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 404..426
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 432..454
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 460..482
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 488..510
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 516..538
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 544..566
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 572..594
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..278
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17055453"
FT /id="VSP_025175"
FT VAR_SEQ 1..93
FT /note="MPELYTEDFIQGCDVGELQEPGLPGVLSYVGAQERALDHRKPSTSSKKTKRV
FT EIDQRCENRLECNGAISAHCNLRLPDSNDSPASASRVAGIT -> MAFTQLTFRDVAIE
FT FSQDEWKCLNSTQRTLYRDVMLENYRNLVSL (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17055453"
FT /id="VSP_025176"
FT VAR_SEQ 1..93
FT /note="MPELYTEDFIQGCDVGELQEPGLPGVLSYVGAQERALDHRKPSTSSKKTKRV
FT EIDQRCENRLECNGAISAHCNLRLPDSNDSPASASRVAGIT -> MDGDGLTFRDVAIE
FT FSQDEWKCLNSTQRTLYRDVMLENYRNLVSL (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044807"
FT VAR_SEQ 1..92
FT /note="MPELYTEDFIQGCDVGELQEPGLPGVLSYVGAQERALDHRKPSTSSKKTKRV
FT EIDQRCENRLECNGAISAHCNLRLPDSNDSPASASRVAGI -> MWEHRKEPWTIESQV
FT RVARKPKGWEWIKGVK (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17055453"
FT /id="VSP_025177"
FT VAR_SEQ 26..61
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17055453"
FT /id="VSP_025178"
FT VARIANT 196
FT /note="H -> P (in dbSNP:rs16984466)"
FT /id="VAR_032166"
FT VARIANT 229
FT /note="I -> L (in dbSNP:rs1054485)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17055453"
FT /id="VAR_032167"
FT VARIANT 233
FT /note="I -> V (in dbSNP:rs1133327)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17055453"
FT /id="VAR_032168"
FT VARIANT 241
FT /note="Y -> C (in dbSNP:rs1560099)"
FT /id="VAR_032169"
FT VARIANT 463
FT /note="N -> D (in dbSNP:rs10410030)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032170"
SQ SEQUENCE 603 AA; 68798 MW; 6B62D29A4E6E9300 CRC64;
MPELYTEDFI QGCDVGELQE PGLPGVLSYV GAQERALDHR KPSTSSKKTK RVEIDQRCEN
RLECNGAISA HCNLRLPDSN DSPASASRVA GITDLSRNCV IKELAPQQEG NPGEVFHTVT
LEQHEKHDIE EFCFREIKKK IHDFDCQWRD DERNCNKVTT APKENLTCRR DQRDRRGIGN
KSIKHQLGLS FLPHPHELQQ FQAEGKIYEC NHVEKSVNHG SSVSPPQIIS STIKTHVSNK
YGTDFICSSL LTQEQKSCIR EKPYRYIECD KALNHGSHMT VRQVSHSGEK GYKCDLCGKV
FSQKSNLARH WRVHTGEKPY KCNECDRSFS RNSCLALHRR VHTGEKPYKC YECDKVFSRN
SCLALHQKTH IGEKPYTCKE CGKAFSVRST LTNHQVIHSG KKPYKCNECG KVFSQTSSLA
THQRIHTGEK PYKCNECGKV FSQTSSLARH WRIHTGEKPY KCNECGKVFS YNSHLASHRR
VHTGEKPYKC NECGKAFSVH SNLTTHQVIH TGEKPYKCNQ CGKGFSVHSS LTTHQVIHTG
EKPYKCNECG KSFSVRPNLT RHQIIHTGKK PYKCSDCGKS FSVRPNLFRH QIIHTKEKPY
KRN
