ZN416_HUMAN
ID ZN416_HUMAN Reviewed; 594 AA.
AC Q9BWM5; Q9NWW8;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger protein 416;
GN Name=ZNF416;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-483.
RC TISSUE=Carcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91257.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; BC000130; AAH00130.1; -; mRNA.
DR EMBL; AK000564; BAA91257.1; ALT_SEQ; mRNA.
DR CCDS; CCDS12954.1; -.
DR RefSeq; NP_060349.1; NM_017879.1.
DR AlphaFoldDB; Q9BWM5; -.
DR SMR; Q9BWM5; -.
DR BioGRID; 120791; 8.
DR IntAct; Q9BWM5; 6.
DR STRING; 9606.ENSP00000196489; -.
DR iPTMnet; Q9BWM5; -.
DR PhosphoSitePlus; Q9BWM5; -.
DR BioMuta; ZNF416; -.
DR DMDM; 74762716; -.
DR EPD; Q9BWM5; -.
DR MassIVE; Q9BWM5; -.
DR MaxQB; Q9BWM5; -.
DR PaxDb; Q9BWM5; -.
DR PeptideAtlas; Q9BWM5; -.
DR PRIDE; Q9BWM5; -.
DR Antibodypedia; 19655; 100 antibodies from 21 providers.
DR DNASU; 55659; -.
DR Ensembl; ENST00000196489.4; ENSP00000196489.2; ENSG00000083817.9.
DR GeneID; 55659; -.
DR KEGG; hsa:55659; -.
DR MANE-Select; ENST00000196489.4; ENSP00000196489.2; NM_017879.3; NP_060349.1.
DR UCSC; uc002qpf.4; human.
DR CTD; 55659; -.
DR GeneCards; ZNF416; -.
DR HGNC; HGNC:20645; ZNF416.
DR HPA; ENSG00000083817; Low tissue specificity.
DR neXtProt; NX_Q9BWM5; -.
DR OpenTargets; ENSG00000083817; -.
DR PharmGKB; PA134905500; -.
DR VEuPathDB; HostDB:ENSG00000083817; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164114; -.
DR HOGENOM; CLU_002678_55_4_1; -.
DR InParanoid; Q9BWM5; -.
DR OMA; CECSLVQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9BWM5; -.
DR TreeFam; TF339848; -.
DR PathwayCommons; Q9BWM5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9BWM5; -.
DR BioGRID-ORCS; 55659; 4 hits in 1090 CRISPR screens.
DR ChiTaRS; ZNF416; human.
DR GenomeRNAi; 55659; -.
DR Pharos; Q9BWM5; Tdark.
DR PRO; PR:Q9BWM5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9BWM5; protein.
DR Bgee; ENSG00000083817; Expressed in secondary oocyte and 128 other tissues.
DR Genevisible; Q9BWM5; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..594
FT /note="Zinc finger protein 416"
FT /id="PRO_0000233984"
FT DOMAIN 28..111
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 242..264
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 438..460
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 466..488
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 494..516
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 522..544
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 550..572
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 569..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 463
FT /note="E -> I (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 594 AA; 67188 MW; 6ABC5ED049066C6D CRC64;
MAAAVLRDST SVPVTAEAKL MGFTQGCVTF EDVAIYFSQE EWGLLDEAQR LLYRDVMLEN
FALITALVCW HGMEDEETPE QSVSVEGVPQ VRTPEASPST QKIQSCDMCV PFLTDILHLT
DLPGQELYLT GACAVFHQDQ KHHSAEKPLE SDMDKASFVQ CCLFHESGMP FTSSEVGKDF
LAPLGILQPQ AIANYEKPNK ISKCEEAFHV GISHYKWSQC RRESSHKHTF FHPRVCTGKR
LYESSKCGKA CCCECSLVQL QRVHPGERPY ECSECGKSFS QTSHLNDHRR IHTGERPYVC
GQCGKSFSQR ATLIKHHRVH TGERPYECGE CGKSFSQSSN LIEHCRIHTG ERPYECDECG
KAFGSKSTLV RHQRTHTGEK PYECGECGKL FRQSFSLVVH QRIHTTARPY ECGQCGKSFS
LKCGLIQHQL IHSGARPFEC DECGKSFSQR TTLNKHHKVH TAERPYVCGE CGKAFMFKSK
LVRHQRTHTG ERPFECSECG KFFRQSYTLV EHQKIHTGLR PYDCGQCGKS FIQKSSLIQH
QVVHTGERPY ECGKCGKSFT QHSGLILHRK SHTVERPRDS SKCGKPYSPR SNIV
