ZN417_HUMAN
ID ZN417_HUMAN Reviewed; 575 AA.
AC Q8TAU3; B4DEU1;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Zinc finger protein 417;
GN Name=ZNF417;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-495.
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8TAU3; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-740727, EBI-10173507;
CC Q8TAU3; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-740727, EBI-4400025;
CC Q8TAU3; Q9BUH8: BEGAIN; NbExp=6; IntAct=EBI-740727, EBI-742722;
CC Q8TAU3; Q7L4P6: BEND5; NbExp=3; IntAct=EBI-740727, EBI-724373;
CC Q8TAU3; Q00994: BEX3; NbExp=3; IntAct=EBI-740727, EBI-741753;
CC Q8TAU3; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-740727, EBI-11519926;
CC Q8TAU3; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-740727, EBI-11975051;
CC Q8TAU3; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-740727, EBI-2548012;
CC Q8TAU3; Q53FE4: C4orf17; NbExp=3; IntAct=EBI-740727, EBI-715110;
CC Q8TAU3; Q9H257: CARD9; NbExp=3; IntAct=EBI-740727, EBI-751319;
CC Q8TAU3; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-740727, EBI-11524851;
CC Q8TAU3; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-740727, EBI-744556;
CC Q8TAU3; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-740727, EBI-11977221;
CC Q8TAU3; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-740727, EBI-10171416;
CC Q8TAU3; Q2TAC2: CCDC57; NbExp=3; IntAct=EBI-740727, EBI-2808286;
CC Q8TAU3; O95273: CCNDBP1; NbExp=4; IntAct=EBI-740727, EBI-748961;
CC Q8TAU3; Q01850: CDR2; NbExp=3; IntAct=EBI-740727, EBI-1181367;
CC Q8TAU3; Q86X02: CDR2L; NbExp=3; IntAct=EBI-740727, EBI-11063830;
CC Q8TAU3; Q9C0F1: CEP44; NbExp=4; IntAct=EBI-740727, EBI-744115;
CC Q8TAU3; Q8NHQ1: CEP70; NbExp=6; IntAct=EBI-740727, EBI-739624;
CC Q8TAU3; Q5SZL2-5: CEP85L; NbExp=3; IntAct=EBI-740727, EBI-12344751;
CC Q8TAU3; Q6WN34-2: CHRDL2; NbExp=3; IntAct=EBI-740727, EBI-12593838;
CC Q8TAU3; Q9Y2V7: COG6; NbExp=3; IntAct=EBI-740727, EBI-3866319;
CC Q8TAU3; Q96S65: CSRNP1; NbExp=3; IntAct=EBI-740727, EBI-4311573;
CC Q8TAU3; A8MQ03: CYSRT1; NbExp=5; IntAct=EBI-740727, EBI-3867333;
CC Q8TAU3; Q6ZN54-2: DEF8; NbExp=3; IntAct=EBI-740727, EBI-12346463;
CC Q8TAU3; Q92997: DVL3; NbExp=3; IntAct=EBI-740727, EBI-739789;
CC Q8TAU3; O43281: EFS; NbExp=3; IntAct=EBI-740727, EBI-718488;
CC Q8TAU3; Q86X51: EZHIP; NbExp=3; IntAct=EBI-740727, EBI-12827735;
CC Q8TAU3; A4D161: FAM221A; NbExp=3; IntAct=EBI-740727, EBI-11960181;
CC Q8TAU3; Q14192: FHL2; NbExp=3; IntAct=EBI-740727, EBI-701903;
CC Q8TAU3; Q13643: FHL3; NbExp=3; IntAct=EBI-740727, EBI-741101;
CC Q8TAU3; Q5TD97: FHL5; NbExp=3; IntAct=EBI-740727, EBI-750641;
CC Q8TAU3; O43559: FRS3; NbExp=3; IntAct=EBI-740727, EBI-725515;
CC Q8TAU3; A1L4K1: FSD2; NbExp=6; IntAct=EBI-740727, EBI-5661036;
CC Q8TAU3; P19883: FST; NbExp=3; IntAct=EBI-740727, EBI-1571188;
CC Q8TAU3; P51114-2: FXR1; NbExp=3; IntAct=EBI-740727, EBI-11022345;
CC Q8TAU3; Q08379: GOLGA2; NbExp=6; IntAct=EBI-740727, EBI-618309;
CC Q8TAU3; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-740727, EBI-5916454;
CC Q8TAU3; Q6NT76: HMBOX1; NbExp=6; IntAct=EBI-740727, EBI-2549423;
CC Q8TAU3; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-740727, EBI-10961706;
CC Q8TAU3; P49639: HOXA1; NbExp=5; IntAct=EBI-740727, EBI-740785;
CC Q8TAU3; O75031: HSF2BP; NbExp=3; IntAct=EBI-740727, EBI-7116203;
CC Q8TAU3; P24592: IGFBP6; NbExp=5; IntAct=EBI-740727, EBI-947015;
CC Q8TAU3; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-740727, EBI-8638439;
CC Q8TAU3; Q13422: IKZF1; NbExp=3; IntAct=EBI-740727, EBI-745305;
CC Q8TAU3; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-740727, EBI-11522367;
CC Q8TAU3; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-740727, EBI-747204;
CC Q8TAU3; Q96EL1: INKA1; NbExp=3; IntAct=EBI-740727, EBI-10285157;
CC Q8TAU3; A0A0C4DFT8: JADE2; NbExp=3; IntAct=EBI-740727, EBI-12094820;
CC Q8TAU3; O75564-2: JRK; NbExp=3; IntAct=EBI-740727, EBI-17181882;
CC Q8TAU3; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-740727, EBI-2556193;
CC Q8TAU3; Q92993: KAT5; NbExp=3; IntAct=EBI-740727, EBI-399080;
CC Q8TAU3; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-740727, EBI-715394;
CC Q8TAU3; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-740727, EBI-11954971;
CC Q8TAU3; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-740727, EBI-3437878;
CC Q8TAU3; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-740727, EBI-8472129;
CC Q8TAU3; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-740727, EBI-14069005;
CC Q8TAU3; Q6P597: KLC3; NbExp=3; IntAct=EBI-740727, EBI-1643885;
CC Q8TAU3; P19012: KRT15; NbExp=3; IntAct=EBI-740727, EBI-739566;
CC Q8TAU3; Q15323: KRT31; NbExp=3; IntAct=EBI-740727, EBI-948001;
CC Q8TAU3; Q92764: KRT35; NbExp=3; IntAct=EBI-740727, EBI-1058674;
CC Q8TAU3; O76015: KRT38; NbExp=6; IntAct=EBI-740727, EBI-1047263;
CC Q8TAU3; Q6A163: KRT39; NbExp=3; IntAct=EBI-740727, EBI-11958242;
CC Q8TAU3; Q6A162: KRT40; NbExp=6; IntAct=EBI-740727, EBI-10171697;
CC Q8TAU3; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-740727, EBI-11749135;
CC Q8TAU3; P60370: KRTAP10-5; NbExp=5; IntAct=EBI-740727, EBI-10172150;
CC Q8TAU3; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-740727, EBI-10172290;
CC Q8TAU3; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-740727, EBI-10171774;
CC Q8TAU3; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-740727, EBI-10172052;
CC Q8TAU3; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-740727, EBI-11953334;
CC Q8TAU3; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-740727, EBI-10302392;
CC Q8TAU3; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-740727, EBI-10172511;
CC Q8TAU3; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-740727, EBI-3958099;
CC Q8TAU3; Q9BQD3: KXD1; NbExp=6; IntAct=EBI-740727, EBI-739657;
CC Q8TAU3; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-740727, EBI-12039345;
CC Q8TAU3; P48059-3: LIMS1; NbExp=3; IntAct=EBI-740727, EBI-12864460;
CC Q8TAU3; P25800: LMO1; NbExp=3; IntAct=EBI-740727, EBI-8639312;
CC Q8TAU3; Q96LR2: LURAP1; NbExp=3; IntAct=EBI-740727, EBI-741355;
CC Q8TAU3; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-740727, EBI-1216080;
CC Q8TAU3; Q9BRK4: LZTS2; NbExp=6; IntAct=EBI-740727, EBI-741037;
CC Q8TAU3; P43361: MAGEA8; NbExp=3; IntAct=EBI-740727, EBI-10182930;
CC Q8TAU3; P23508: MCC; NbExp=3; IntAct=EBI-740727, EBI-307531;
CC Q8TAU3; P59942: MCCD1; NbExp=3; IntAct=EBI-740727, EBI-11987923;
CC Q8TAU3; Q99750: MDFI; NbExp=7; IntAct=EBI-740727, EBI-724076;
CC Q8TAU3; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-740727, EBI-18582591;
CC Q8TAU3; P50222: MEOX2; NbExp=3; IntAct=EBI-740727, EBI-748397;
CC Q8TAU3; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-740727, EBI-16439278;
CC Q8TAU3; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-740727, EBI-10172526;
CC Q8TAU3; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-740727, EBI-2801965;
CC Q8TAU3; Q96HT8: MRFAP1L1; NbExp=3; IntAct=EBI-740727, EBI-748896;
CC Q8TAU3; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-740727, EBI-742948;
CC Q8TAU3; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-740727, EBI-11522433;
CC Q8TAU3; P13349: MYF5; NbExp=3; IntAct=EBI-740727, EBI-17491620;
CC Q8TAU3; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-740727, EBI-6952711;
CC Q8TAU3; Q15742: NAB2; NbExp=3; IntAct=EBI-740727, EBI-8641936;
CC Q8TAU3; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-740727, EBI-928842;
CC Q8TAU3; P17568: NDUFB7; NbExp=3; IntAct=EBI-740727, EBI-1246238;
CC Q8TAU3; Q9Y2I6: NINL; NbExp=4; IntAct=EBI-740727, EBI-719716;
CC Q8TAU3; Q5M9Q1: NKAPL; NbExp=3; IntAct=EBI-740727, EBI-11423380;
CC Q8TAU3; Q99801: NKX3-1; NbExp=3; IntAct=EBI-740727, EBI-1385894;
CC Q8TAU3; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-740727, EBI-945833;
CC Q8TAU3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-740727, EBI-22310682;
CC Q8TAU3; O43482: OIP5; NbExp=3; IntAct=EBI-740727, EBI-536879;
CC Q8TAU3; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-740727, EBI-713786;
CC Q8TAU3; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-740727, EBI-79165;
CC Q8TAU3; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-740727, EBI-10232538;
CC Q8TAU3; O15162: PLSCR1; NbExp=3; IntAct=EBI-740727, EBI-740019;
CC Q8TAU3; Q9UL42: PNMA2; NbExp=4; IntAct=EBI-740727, EBI-302355;
CC Q8TAU3; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-740727, EBI-1567797;
CC Q8TAU3; Q96D15: RCN3; NbExp=3; IntAct=EBI-740727, EBI-746283;
CC Q8TAU3; Q04864: REL; NbExp=3; IntAct=EBI-740727, EBI-307352;
CC Q8TAU3; P17081: RHOQ; NbExp=3; IntAct=EBI-740727, EBI-689202;
CC Q8TAU3; Q5TA31: RNF187; NbExp=3; IntAct=EBI-740727, EBI-6868977;
CC Q8TAU3; Q92753-1: RORB; NbExp=3; IntAct=EBI-740727, EBI-18560266;
CC Q8TAU3; Q96KN7: RPGRIP1; NbExp=3; IntAct=EBI-740727, EBI-1050213;
CC Q8TAU3; Q59EK9: RUNDC3A; NbExp=3; IntAct=EBI-740727, EBI-747225;
CC Q8TAU3; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-740727, EBI-11957366;
CC Q8TAU3; O14492-2: SH2B2; NbExp=3; IntAct=EBI-740727, EBI-19952306;
CC Q8TAU3; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-740727, EBI-358489;
CC Q8TAU3; Q6GMV2: SMYD5; NbExp=3; IntAct=EBI-740727, EBI-11057552;
CC Q8TAU3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-740727, EBI-5235340;
CC Q8TAU3; Q7Z698: SPRED2; NbExp=3; IntAct=EBI-740727, EBI-7082156;
CC Q8TAU3; O43609: SPRY1; NbExp=3; IntAct=EBI-740727, EBI-3866665;
CC Q8TAU3; O43597: SPRY2; NbExp=3; IntAct=EBI-740727, EBI-742487;
CC Q8TAU3; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-740727, EBI-2212028;
CC Q8TAU3; O75558: STX11; NbExp=6; IntAct=EBI-740727, EBI-714135;
CC Q8TAU3; O43463: SUV39H1; NbExp=3; IntAct=EBI-740727, EBI-349968;
CC Q8TAU3; O75478: TADA2A; NbExp=3; IntAct=EBI-740727, EBI-742268;
CC Q8TAU3; P15884: TCF4; NbExp=3; IntAct=EBI-740727, EBI-533224;
CC Q8TAU3; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-740727, EBI-750487;
CC Q8TAU3; Q9UBB9: TFIP11; NbExp=4; IntAct=EBI-740727, EBI-1105213;
CC Q8TAU3; Q08117-2: TLE5; NbExp=3; IntAct=EBI-740727, EBI-11741437;
CC Q8TAU3; Q63HR2: TNS2; NbExp=9; IntAct=EBI-740727, EBI-949753;
CC Q8TAU3; Q13077: TRAF1; NbExp=3; IntAct=EBI-740727, EBI-359224;
CC Q8TAU3; Q12933: TRAF2; NbExp=3; IntAct=EBI-740727, EBI-355744;
CC Q8TAU3; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-740727, EBI-492476;
CC Q8TAU3; P36406: TRIM23; NbExp=3; IntAct=EBI-740727, EBI-740098;
CC Q8TAU3; P14373: TRIM27; NbExp=7; IntAct=EBI-740727, EBI-719493;
CC Q8TAU3; Q9NQ86: TRIM36; NbExp=3; IntAct=EBI-740727, EBI-2341518;
CC Q8TAU3; O94972: TRIM37; NbExp=4; IntAct=EBI-740727, EBI-741602;
CC Q8TAU3; Q8WV44: TRIM41; NbExp=8; IntAct=EBI-740727, EBI-725997;
CC Q8TAU3; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-740727, EBI-2130429;
CC Q8TAU3; Q86WV8: TSC1; NbExp=3; IntAct=EBI-740727, EBI-12806590;
CC Q8TAU3; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-740727, EBI-744794;
CC Q8TAU3; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-740727, EBI-9090990;
CC Q8TAU3; Q6PKC3: TXNDC11; NbExp=3; IntAct=EBI-740727, EBI-749812;
CC Q8TAU3; Q01081: U2AF1; NbExp=3; IntAct=EBI-740727, EBI-632461;
CC Q8TAU3; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-740727, EBI-739895;
CC Q8TAU3; Q6EMK4: VASN; NbExp=3; IntAct=EBI-740727, EBI-10249550;
CC Q8TAU3; Q6GMQ7: VPS16; NbExp=3; IntAct=EBI-740727, EBI-17974829;
CC Q8TAU3; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-740727, EBI-2799833;
CC Q8TAU3; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-740727, EBI-11957238;
CC Q8TAU3; Q9Y2K1: ZBTB1; NbExp=3; IntAct=EBI-740727, EBI-2682961;
CC Q8TAU3; Q96DT7: ZBTB10; NbExp=3; IntAct=EBI-740727, EBI-10235384;
CC Q8TAU3; Q96DT7-3: ZBTB10; NbExp=3; IntAct=EBI-740727, EBI-12017160;
CC Q8TAU3; O43298: ZBTB43; NbExp=4; IntAct=EBI-740727, EBI-740718;
CC Q8TAU3; Q96BR9: ZBTB8A; NbExp=6; IntAct=EBI-740727, EBI-742740;
CC Q8TAU3; Q96C00: ZBTB9; NbExp=3; IntAct=EBI-740727, EBI-395708;
CC Q8TAU3; Q9UDW3: ZMAT5; NbExp=3; IntAct=EBI-740727, EBI-7850213;
CC Q8TAU3; P49910: ZNF165; NbExp=3; IntAct=EBI-740727, EBI-741694;
CC Q8TAU3; P17023: ZNF19; NbExp=3; IntAct=EBI-740727, EBI-12884200;
CC Q8TAU3; P17024: ZNF20; NbExp=3; IntAct=EBI-740727, EBI-717634;
CC Q8TAU3; Q8IVP9: ZNF547; NbExp=3; IntAct=EBI-740727, EBI-12895421;
CC Q8TAU3; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-740727, EBI-10172590;
CC Q8TAU3; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-740727, EBI-6427977;
CC Q8TAU3; Q9UC07-2: ZNF69; NbExp=3; IntAct=EBI-740727, EBI-12310821;
CC Q8TAU3; Q9NQZ8: ZNF71; NbExp=3; IntAct=EBI-740727, EBI-7138235;
CC Q8TAU3; Q9H5H4: ZNF768; NbExp=3; IntAct=EBI-740727, EBI-1210580;
CC Q8TAU3; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-740727, EBI-10251462;
CC Q8TAU3; Q96EG3: ZNF837; NbExp=6; IntAct=EBI-740727, EBI-11962574;
CC Q8TAU3; Q49A12: ZNF85; NbExp=3; IntAct=EBI-740727, EBI-18141506;
CC Q8TAU3; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-740727, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TAU3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TAU3-2; Sequence=VSP_055950;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK293789; BAG57202.1; -; mRNA.
DR EMBL; AC010326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025783; AAH25783.1; -; mRNA.
DR CCDS; CCDS12965.1; -. [Q8TAU3-1]
DR RefSeq; NP_689688.2; NM_152475.2. [Q8TAU3-1]
DR AlphaFoldDB; Q8TAU3; -.
DR SMR; Q8TAU3; -.
DR BioGRID; 127075; 178.
DR IntAct; Q8TAU3; 176.
DR MINT; Q8TAU3; -.
DR STRING; 9606.ENSP00000311319; -.
DR MoonDB; Q8TAU3; Predicted.
DR iPTMnet; Q8TAU3; -.
DR PhosphoSitePlus; Q8TAU3; -.
DR SwissPalm; Q8TAU3; -.
DR BioMuta; ZNF417; -.
DR DMDM; 296453053; -.
DR EPD; Q8TAU3; -.
DR MassIVE; Q8TAU3; -.
DR MaxQB; Q8TAU3; -.
DR PaxDb; Q8TAU3; -.
DR PeptideAtlas; Q8TAU3; -.
DR PRIDE; Q8TAU3; -.
DR ProteomicsDB; 3983; -.
DR ProteomicsDB; 73921; -. [Q8TAU3-1]
DR Antibodypedia; 33317; 99 antibodies from 16 providers.
DR DNASU; 147687; -.
DR Ensembl; ENST00000312026.6; ENSP00000311319.4; ENSG00000173480.11. [Q8TAU3-1]
DR GeneID; 147687; -.
DR KEGG; hsa:147687; -.
DR MANE-Select; ENST00000312026.6; ENSP00000311319.4; NM_152475.3; NP_689688.2.
DR UCSC; uc002qqq.4; human. [Q8TAU3-1]
DR CTD; 147687; -.
DR DisGeNET; 147687; -.
DR GeneCards; ZNF417; -.
DR HGNC; HGNC:20646; ZNF417.
DR HPA; ENSG00000173480; Low tissue specificity.
DR neXtProt; NX_Q8TAU3; -.
DR OpenTargets; ENSG00000173480; -.
DR PharmGKB; PA134863699; -.
DR VEuPathDB; HostDB:ENSG00000173480; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164176; -.
DR InParanoid; Q8TAU3; -.
DR OMA; SKEEWCL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8TAU3; -.
DR TreeFam; TF339848; -.
DR PathwayCommons; Q8TAU3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8TAU3; -.
DR BioGRID-ORCS; 147687; 10 hits in 1015 CRISPR screens.
DR ChiTaRS; ZNF417; human.
DR GenomeRNAi; 147687; -.
DR Pharos; Q8TAU3; Tdark.
DR PRO; PR:Q8TAU3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TAU3; protein.
DR Bgee; ENSG00000173480; Expressed in adenohypophysis and 106 other tissues.
DR ExpressionAtlas; Q8TAU3; baseline and differential.
DR Genevisible; Q8TAU3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..575
FT /note="Zinc finger protein 417"
FT /id="PRO_0000233985"
FT DOMAIN 15..88
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 92..114
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 520..542
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 548..570
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 69..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..199
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055950"
FT VARIANT 495
FT /note="N -> S (in dbSNP:rs10416584)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_060275"
FT CONFLICT 173
FT /note="R -> H (in Ref. 3; AAH25783)"
FT /evidence="ECO:0000305"
FT CONFLICT 316
FT /note="R -> L (in Ref. 3; AAH25783)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 575 AA; 65733 MW; 8CE2FB25CBE474F5 CRC64;
MAAAAPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL ISSLGCWCGS
KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI LEDVFHFADH QETHHKQKLN
RSGACGKNLD DTAYLHQHQK QHIGEKFYRK SVREASFVKK RKLRVSQEPF VFREFGKDVL
PSSGLCQEAA AVEKTDSETM HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY
VCSDCGKSFS RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGKTAYPCEE
CGKSFSQKGS LISHQRVHTG ERPYECREYG KSFGQKGNLI QHQQGHTGER AYHCGECGKS
FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVQHQR GHTGERPYEC KECGKSFRYR
SHLTEHQRLH TGERPYNCRE CGKLFNRKYH LLVHERVHTG ERPYACEVCG KLFGNKNCVT
IHQRIHTGER PYECNECGKS FLSSSALHVH KRVHSGQKPY KCSECGKSFA ECSSLIKHRR
IHTGERPYEC TKCGKTFQRS STLLHHQSSH RRKAL
