ZN418_HUMAN
ID ZN418_HUMAN Reviewed; 676 AA.
AC Q8TF45; Q2M1S2; Q670L5; Q96N18;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2002, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Zinc finger protein 418;
GN Name=ZNF418; Synonyms=KIAA1956;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RA Li Y., Wang Q., Yuan W., Zhu C., Wu X., Liu M.;
RT "ZNF418, a novel KRAB-containing zinc finger protein, is a transcription
RT repressor.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional repressor. {ECO:0000269|Ref.1}.
CC -!- INTERACTION:
CC Q8TF45; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-3446851, EBI-12012928;
CC Q8TF45; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-3446851, EBI-10172290;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB85542.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY695825; AAU05132.1; -; mRNA.
DR EMBL; AB075836; BAB85542.1; ALT_INIT; mRNA.
DR EMBL; AK056113; BAB71096.1; -; mRNA.
DR EMBL; BC112244; AAI12245.1; -; mRNA.
DR EMBL; BC113707; AAI13708.1; -; mRNA.
DR CCDS; CCDS42642.1; -.
DR RefSeq; NP_001303956.1; NM_001317027.1.
DR RefSeq; NP_001303957.1; NM_001317028.1.
DR RefSeq; NP_001303958.1; NM_001317029.1.
DR RefSeq; NP_001303959.1; NM_001317030.1.
DR RefSeq; NP_597717.1; NM_133460.2.
DR RefSeq; XP_016881801.1; XM_017026312.1.
DR RefSeq; XP_016881802.1; XM_017026313.1.
DR AlphaFoldDB; Q8TF45; -.
DR SMR; Q8TF45; -.
DR BioGRID; 127074; 22.
DR IntAct; Q8TF45; 3.
DR STRING; 9606.ENSP00000379451; -.
DR iPTMnet; Q8TF45; -.
DR PhosphoSitePlus; Q8TF45; -.
DR BioMuta; ZNF418; -.
DR DMDM; 23396985; -.
DR MassIVE; Q8TF45; -.
DR PaxDb; Q8TF45; -.
DR PeptideAtlas; Q8TF45; -.
DR PRIDE; Q8TF45; -.
DR ProteomicsDB; 74554; -.
DR Antibodypedia; 33292; 55 antibodies from 16 providers.
DR DNASU; 147686; -.
DR Ensembl; ENST00000396147.6; ENSP00000379451.1; ENSG00000196724.13.
DR Ensembl; ENST00000595830.5; ENSP00000471652.1; ENSG00000196724.13.
DR Ensembl; ENST00000616958.1; ENSP00000483763.1; ENSG00000196724.13.
DR GeneID; 147686; -.
DR KEGG; hsa:147686; -.
DR MANE-Select; ENST00000396147.6; ENSP00000379451.1; NM_133460.3; NP_597717.1.
DR UCSC; uc002qqs.1; human.
DR CTD; 147686; -.
DR DisGeNET; 147686; -.
DR GeneCards; ZNF418; -.
DR HGNC; HGNC:20647; ZNF418.
DR HPA; ENSG00000196724; Low tissue specificity.
DR MIM; 619509; gene.
DR neXtProt; NX_Q8TF45; -.
DR OpenTargets; ENSG00000196724; -.
DR PharmGKB; PA134912102; -.
DR VEuPathDB; HostDB:ENSG00000196724; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164269; -.
DR HOGENOM; CLU_002678_55_2_1; -.
DR InParanoid; Q8TF45; -.
DR OMA; YDGFSNH; -.
DR PhylomeDB; Q8TF45; -.
DR TreeFam; TF339848; -.
DR PathwayCommons; Q8TF45; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8TF45; -.
DR BioGRID-ORCS; 147686; 8 hits in 1091 CRISPR screens.
DR ChiTaRS; ZNF418; human.
DR GenomeRNAi; 147686; -.
DR Pharos; Q8TF45; Tdark.
DR PRO; PR:Q8TF45; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TF45; protein.
DR Bgee; ENSG00000196724; Expressed in cortical plate and 111 other tissues.
DR ExpressionAtlas; Q8TF45; baseline and differential.
DR Genevisible; Q8TF45; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 15.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 17.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..676
FT /note="Zinc finger protein 418"
FT /id="PRO_0000047573"
FT DOMAIN 5..91
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 82..105
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 230..252
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 258..280
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 286..308
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 314..336
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 342..364
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 398..420
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 426..448
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 454..476
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 482..504
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 510..532
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 538..560
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 591..613
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 619..641
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 647..669
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 290
FT /note="E -> G (in Ref. 3; BAB71096)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 676 AA; 77858 MW; 1BB0F0064B8F3BD3 CRC64;
MQGTVAFEDV AVNFSQEEWS LLSEVQRCLY HDVMLENWVL ISSLGCWCGS EDEEAPSKKS
ISIQRVSQVS TPGAGVSPKK AHSCEMCGAI LGDILHLADH QGTHHKQKLH RCEAWGNKLY
DSSNRPHQNQ YLGEKPYRSS VEEALFVKRC KFHVSEESSI FIQSGKDFLP SSGLLLQEAT
HTGEKSNSKP ECESPFQWGD THYSCGECMK HSSTKHVFVQ QQRLPSREEC YCWECGKSFS
KYDSVSNHQR VHTGKRPYEC GECGKSFSHK GSLVQHQRVH TGKRPYECGE CGKSFSHKGS
LVQHQRVHTG ERPYECGECG KSFSQNGTLI KHQRVHTGER PYECEECGKC FTQKGNLIQH
QRGHTSERPY ECEECGKCFS QKGTLTEHHR VHTRERPYEC GECGKSFSRK GHLRNHQRGH
TGERPYECGE CGKSFSRKGN LIQHQRSHTG ERPYECRECR KLFRGKSHLI EHQRVHTGER
PYECNECGKS FQDSSGFRVH QRVHTGEKPF ECSECGKSFP QSCSLLRHRR VHTGERPYEC
GECGKSFHQS SSLLRHQKTH TAERPYECRE CGKFFSSLLE HRRVHTGERP YECRECGKTF
TRRSAHFKHQ RLHTRGKPYE CSECGKSFAE TFSLTEHRRV HTGERPYECS ECGKSFHRSS
SLLRHQRVHT ERSPYK
