ZN420_BOVIN
ID ZN420_BOVIN Reviewed; 687 AA.
AC A2VDQ7;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Zinc finger protein 420;
GN Name=ZNF420;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; BC133352; AAI33353.1; -; mRNA.
DR RefSeq; NP_001096022.1; NM_001102552.1.
DR AlphaFoldDB; A2VDQ7; -.
DR SMR; A2VDQ7; -.
DR STRING; 9913.ENSBTAP00000049685; -.
DR PaxDb; A2VDQ7; -.
DR GeneID; 100124518; -.
DR KEGG; bta:100124518; -.
DR CTD; 147923; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; A2VDQ7; -.
DR OrthoDB; 1318335at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 18.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 19.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..687
FT /note="Zinc finger protein 420"
FT /id="PRO_0000347241"
FT DOMAIN 6..95
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 138..160
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 166..188
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 194..216
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 222..244
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 250..272
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 278..300
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 306..328
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 334..356
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 362..384
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 390..412
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 418..440
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 446..468
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 474..496
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 502..524
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 530..552
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 558..580
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 586..608
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 614..636
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 642..664
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 297
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8TAQ5"
SQ SEQUENCE 687 AA; 79571 MW; 0D7D12A1B44B47DF CRC64;
MAQRSVMFRD VAIDFSQEEW DCLDSAQRDL YRDVMLENYS NLVSLDLPSR GANKLLSPKK
DIYETGLSQW EMSARLENCD LENSSSRDYL EVKGTLEKQQ ENQAYFSQGM IIYDNMSIFN
QHAYLSQHPR CHSTEKPYKC KECGKAFRRA SHLTQHQSIH TGEKPYECKQ CGKAFSRDSQ
LSLHQRLHTG EKPYACKECG KAFTQSSQLI LHHRIHTGEK PYKCEECGKA FIRSSQLTRH
QKVHTGEKPY ECKECGKAFT QNSQLTLHQR LHTGEKLYEC KECRKVFTQL SQLILHKRIH
TGEKPYECKE CGKAFICGSQ LSQHQKIHNG EKPYECQECG KAFIRGSLLM QHQRIHTGEK
PYKCEECGKA FIRGSQLTQH QRIHTNEKPY ECKECGKTFS HGSQLTQHQR IHTGEKPYQC
KECGKAFNRG SLLTRHQRIH TGEKPYECKE CGKTFSRGSE LTQHERIHTG EKPYECKECG
KSFIRGSQLT QHQRIHTGEK PYECKECRMA FTQSSHLSQH QRLHTGEKPY VCNECGKAFA
RGLLLIQHQR IHTGEKPYQC KECGKAFIRG SQLTQHQRIH TGEKPYGCKE CGKAFSHGSQ
LTLHQRIHTG EKPYECKECR KAFTQSSHLS RHQRVHTGEK PYQCRECGKA FTRGSQLTQH
QRIHISEKSF AYKECGIDFS HDSQVYI
