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ZN420_BOVIN
ID   ZN420_BOVIN             Reviewed;         687 AA.
AC   A2VDQ7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Zinc finger protein 420;
GN   Name=ZNF420;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC133352; AAI33353.1; -; mRNA.
DR   RefSeq; NP_001096022.1; NM_001102552.1.
DR   AlphaFoldDB; A2VDQ7; -.
DR   SMR; A2VDQ7; -.
DR   STRING; 9913.ENSBTAP00000049685; -.
DR   PaxDb; A2VDQ7; -.
DR   GeneID; 100124518; -.
DR   KEGG; bta:100124518; -.
DR   CTD; 147923; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; A2VDQ7; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 18.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 19.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 10.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 19.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE   2: Evidence at transcript level;
KW   DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..687
FT                   /note="Zinc finger protein 420"
FT                   /id="PRO_0000347241"
FT   DOMAIN          6..95
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         138..160
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         166..188
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         194..216
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         222..244
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         250..272
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         278..300
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         306..328
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         334..356
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         362..384
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         390..412
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         418..440
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         446..468
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         474..496
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         502..524
FT                   /note="C2H2-type 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         530..552
FT                   /note="C2H2-type 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         558..580
FT                   /note="C2H2-type 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         586..608
FT                   /note="C2H2-type 17"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         614..636
FT                   /note="C2H2-type 18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         642..664
FT                   /note="C2H2-type 19"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   CROSSLNK        297
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TAQ5"
SQ   SEQUENCE   687 AA;  79571 MW;  0D7D12A1B44B47DF CRC64;
     MAQRSVMFRD VAIDFSQEEW DCLDSAQRDL YRDVMLENYS NLVSLDLPSR GANKLLSPKK
     DIYETGLSQW EMSARLENCD LENSSSRDYL EVKGTLEKQQ ENQAYFSQGM IIYDNMSIFN
     QHAYLSQHPR CHSTEKPYKC KECGKAFRRA SHLTQHQSIH TGEKPYECKQ CGKAFSRDSQ
     LSLHQRLHTG EKPYACKECG KAFTQSSQLI LHHRIHTGEK PYKCEECGKA FIRSSQLTRH
     QKVHTGEKPY ECKECGKAFT QNSQLTLHQR LHTGEKLYEC KECRKVFTQL SQLILHKRIH
     TGEKPYECKE CGKAFICGSQ LSQHQKIHNG EKPYECQECG KAFIRGSLLM QHQRIHTGEK
     PYKCEECGKA FIRGSQLTQH QRIHTNEKPY ECKECGKTFS HGSQLTQHQR IHTGEKPYQC
     KECGKAFNRG SLLTRHQRIH TGEKPYECKE CGKTFSRGSE LTQHERIHTG EKPYECKECG
     KSFIRGSQLT QHQRIHTGEK PYECKECRMA FTQSSHLSQH QRLHTGEKPY VCNECGKAFA
     RGLLLIQHQR IHTGEKPYQC KECGKAFIRG SQLTQHQRIH TGEKPYGCKE CGKAFSHGSQ
     LTLHQRIHTG EKPYECKECR KAFTQSSHLS RHQRVHTGEK PYQCRECGKA FTRGSQLTQH
     QRIHISEKSF AYKECGIDFS HDSQVYI
 
 
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