ID   CC70A_DANRE             Reviewed;         269 AA.
AC   Q1LY84;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=UPF0524 protein C3orf70 homolog A;
GN   Name=c3orf70a {ECO:0000303|PubMed:31623237}; ORFNames=si:dkey-22o12.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
RX   PubMed=31623237; DOI=10.3390/ph12040156;
RA   Ashikawa Y., Shiromizu T., Miura K., Adachi Y., Matsui T., Bessho Y.,
RA   Tanaka T., Nishimura Y.;
RT   "C3orf70 Is Involved in Neural and Neurobehavioral Development.";
RL   Pharmaceuticals (Basel) 12:0-0(2019).
CC   -!- FUNCTION: Plays a role in neuronal and neurobehavioral development
CC       (PubMed:31623237). Required for normal expression of neuronal markers
CC       elavl3 and eno2 and neurobehaviors related to circadian rhythm and
CC       changes in light-dark conditions (PubMed:31623237).
CC       {ECO:0000269|PubMed:31623237}.
CC   -!- DEVELOPMENTAL STAGE: Highly expressed in the gut, myotomes and brain,
CC       especially the midbrain and hindbrain, at 3 days post-fertilization
CC       (dpf). {ECO:0000269|PubMed:31623237}.
CC   -!- DISRUPTION PHENOTYPE: Double knockout of c3orf70a and c3orf70b resulted
CC       in significantly decreased expression of the mature neuron markers
CC       elavl3 and eno2 and the midbrain/hindbrain marker irx3b. Neurobehaviors
CC       related to circadian rhythm and altered light-dark conditions were
CC       significantly impaired. {ECO:0000269|PubMed:31623237}.
CC   -!- SIMILARITY: Belongs to the UPF0524 family. {ECO:0000305}.
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DR   EMBL; BX088533; CAK10811.1; -; Genomic_DNA.
DR   RefSeq; NP_001119939.1; NM_001126467.1.
DR   AlphaFoldDB; Q1LY84; -.
DR   STRING; 7955.ENSDARP00000105219; -.
DR   PaxDb; Q1LY84; -.
DR   Ensembl; ENSDART00000125759; ENSDARP00000105219; ENSDARG00000091513.
DR   GeneID; 100000151; -.
DR   KEGG; dre:100000151; -.
DR   ZFIN; ZDB-GENE-060503-443; si:dkey-22o12.2.
DR   eggNOG; ENOG502QQSJ; Eukaryota.
DR   GeneTree; ENSGT00390000006618; -.
DR   HOGENOM; CLU_081879_0_0_1; -.
DR   InParanoid; Q1LY84; -.
DR   OMA; KFCVISD; -.
DR   OrthoDB; 1244564at2759; -.
DR   PhylomeDB; Q1LY84; -.
DR   TreeFam; TF328625; -.
DR   PRO; PR:Q1LY84; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000091513; Expressed in swim bladder and 19 other tissues.
DR   GO; GO:0048512; P:circadian behavior; IMP:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR   InterPro; IPR029670; UPF0524_fam.
DR   PANTHER; PTHR31785; PTHR31785; 1.
DR   Pfam; PF15823; UPF0524; 1.
PE   2: Evidence at transcript level;
KW   Neurogenesis; Reference proteome.
FT   CHAIN           1..269
FT                   /note="UPF0524 protein C3orf70 homolog A"
FT                   /id="PRO_0000319978"
FT   REGION          139..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..156
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..175
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..234
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..249
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   269 AA;  29394 MW;  256A1FE4D14CE1E0 CRC64;
     MAASGGQKSE KLDEAQALAR SCAGRPDFLP CDGLSICATH SHGKCFKLHW CCHLGWCHCK
     YVYQPMTSVC QLPSTAVPVA PSGHTHTMNL SISLAERFLR TAPKFQAPPC PESPKFCVIS
     DLFVDDYMVK RINGKMCYVQ RPPPPTPNPT HQPQTAAPQP VPQRSKNSHQ VGPTVKQGQA
     KEKISAPKMD HCSSPSSSED SGINALGLHY MESCDEDSCV DDDDEEEEDD ELSTDGNSSP
     GSFWDQDECT LLSPSKSIVE IIEKIETTV