ZN420_HUMAN
ID ZN420_HUMAN Reviewed; 688 AA.
AC Q8TAQ5; B2RDY6; Q96ML5;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger protein 420;
GN Name=ZNF420;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-298, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8TAQ5; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-3923307, EBI-8643161;
CC Q8TAQ5; Q8N726: CDKN2A; NbExp=8; IntAct=EBI-3923307, EBI-625922;
CC Q8TAQ5; Q96LK0: CEP19; NbExp=3; IntAct=EBI-3923307, EBI-741885;
CC Q8TAQ5; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-3923307, EBI-371876;
CC Q8TAQ5; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-3923307, EBI-10172290;
CC Q8TAQ5; P04637: TP53; NbExp=4; IntAct=EBI-3923307, EBI-366083;
CC Q8TAQ5; P36508: ZNF76; NbExp=3; IntAct=EBI-3923307, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TAQ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TAQ5-2; Sequence=VSP_055951, VSP_055952;
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DR EMBL; AK056753; BAB71272.1; -; mRNA.
DR EMBL; AK315728; BAG38083.1; -; mRNA.
DR EMBL; AC008733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC012309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026210; AAH26210.1; -; mRNA.
DR CCDS; CCDS12498.1; -. [Q8TAQ5-1]
DR CCDS; CCDS86757.1; -. [Q8TAQ5-2]
DR RefSeq; NP_001316451.1; NM_001329522.1. [Q8TAQ5-2]
DR RefSeq; NP_653290.2; NM_144689.4. [Q8TAQ5-1]
DR RefSeq; XP_011524805.1; XM_011526503.2. [Q8TAQ5-1]
DR RefSeq; XP_011524806.1; XM_011526504.2. [Q8TAQ5-1]
DR AlphaFoldDB; Q8TAQ5; -.
DR SMR; Q8TAQ5; -.
DR BioGRID; 127098; 38.
DR IntAct; Q8TAQ5; 20.
DR MINT; Q8TAQ5; -.
DR STRING; 9606.ENSP00000338770; -.
DR iPTMnet; Q8TAQ5; -.
DR PhosphoSitePlus; Q8TAQ5; -.
DR BioMuta; ZNF420; -.
DR DMDM; 71153480; -.
DR EPD; Q8TAQ5; -.
DR jPOST; Q8TAQ5; -.
DR MassIVE; Q8TAQ5; -.
DR PaxDb; Q8TAQ5; -.
DR PeptideAtlas; Q8TAQ5; -.
DR PRIDE; Q8TAQ5; -.
DR ProteomicsDB; 73908; -. [Q8TAQ5-1]
DR ProteomicsDB; 77371; -.
DR Antibodypedia; 29858; 123 antibodies from 22 providers.
DR DNASU; 147923; -.
DR Ensembl; ENST00000304239.11; ENSP00000306102.7; ENSG00000197050.11. [Q8TAQ5-2]
DR Ensembl; ENST00000337995.4; ENSP00000338770.2; ENSG00000197050.11. [Q8TAQ5-1]
DR GeneID; 147923; -.
DR KEGG; hsa:147923; -.
DR MANE-Select; ENST00000337995.4; ENSP00000338770.2; NM_144689.5; NP_653290.2.
DR UCSC; uc002ofl.4; human. [Q8TAQ5-1]
DR CTD; 147923; -.
DR DisGeNET; 147923; -.
DR GeneCards; ZNF420; -.
DR HGNC; HGNC:20649; ZNF420.
DR HPA; ENSG00000197050; Low tissue specificity.
DR neXtProt; NX_Q8TAQ5; -.
DR OpenTargets; ENSG00000197050; -.
DR PharmGKB; PA134958420; -.
DR VEuPathDB; HostDB:ENSG00000197050; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161335; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8TAQ5; -.
DR OMA; WECLDFA; -.
DR PhylomeDB; Q8TAQ5; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q8TAQ5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR Reactome; R-HSA-6803204; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.
DR SignaLink; Q8TAQ5; -.
DR BioGRID-ORCS; 147923; 9 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF420; human.
DR GenomeRNAi; 147923; -.
DR Pharos; Q8TAQ5; Tbio.
DR PRO; PR:Q8TAQ5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TAQ5; protein.
DR Bgee; ENSG00000197050; Expressed in middle temporal gyrus and 199 other tissues.
DR ExpressionAtlas; Q8TAQ5; baseline and differential.
DR Genevisible; Q8TAQ5; HS.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 16.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 19.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..688
FT /note="Zinc finger protein 420"
FT /id="PRO_0000047575"
FT DOMAIN 6..86
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 139..161
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 167..189
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 195..217
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 223..245
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 251..273
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 279..301
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 307..329
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 335..357
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 363..385
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 419..441
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 447..469
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 475..497
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 503..525
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 531..553
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 559..581
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 587..609
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 615..637
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 643..665
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 298
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 471..536
FT /note="GEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQ
FT RLHTGEKPYVCNEC -> AFLAGQQDRSDIYMSRRFTKSIFPVFFSVPTMWTSKLELRY
FT SHGDFENGIWVLWIMEQKYRRSLQP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055951"
FT VAR_SEQ 537..688
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055952"
SQ SEQUENCE 688 AA; 80247 MW; 70E984F166F8A975 CRC64;
MARKLVMFRD VAIDFSQEEW ECLDSAQRDL YRDVMLENYS NLVSLDLPSR CASKDLSPEK
NTYETELSQW EMSDRLENCD LEESNSRDYL EAKGKMEKQQ ENQKEYFRQG MIIYDKMSIF
NQHTYLSQHS RCHSTEKPYK CKECGKAFRR ASHLTQHQSI HTGEKPYECK QCGKAFSRDS
QLSLHQRLHT GEKPYACKEC GKAFTQSSQL ILHHRIHTGE KPYKCEECGK AFIRSSQLTR
HQKVHTGEKP YECKECGKAF TQNSQLTLHQ RLHTGEKLYE CKECRKVFTQ LSQLILHKRI
HTGEKPYECK ECGKAFICGS QLSQHQKIHN GEKPYECKEC GRAFIRGSLL MQHQRIHTGE
KPYKCEECGK AFIRGSQLTQ HQRIHTNEKP YECKECGKMF SHGSQLTQHQ RIHTGEKPYQ
CKECGKAFNR GSLLTRHQRI HTGEKPYECK ECGKTFSRGS ELTQHERIHT GEKPYECKEC
GKSFIRGSQL TQHQRIHTGE KPYECKECRM AFTQSSHLSQ HQRLHTGEKP YVCNECGKAF
ARGLLLIQHQ RIHTGEKPYQ CKECGKAFIR GSQLTQHQRI HTGEKPYECK ECGKAFSHGS
QLTLHQRIHT GEKPYECREC RKAFTQSSHL SRHQRIHTGE KPYQCKECGK AFTRGSQLTQ
HQRIHISEKS FEYKECGIDF SHGSQVYM
