ZN423_DROME
ID ZN423_DROME Reviewed; 1228 AA.
AC A1Z9R4; Q8T496;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Zinc finger protein 423 homolog;
DE AltName: Full=O/E-associated zinc finger protein {ECO:0000303|PubMed:17323106};
GN Name=Oaz {ECO:0000303|PubMed:17323106, ECO:0000312|FlyBase:FBgn0284250};
GN ORFNames=CG42702 {ECO:0000312|FlyBase:FBgn0284250};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-1228.
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=17323106; DOI=10.1007/s00427-007-0134-7;
RA Krattinger A., Gendre N., Ramaekers A., Grillenzoni N., Stocker R.F.;
RT "DmOAZ, the unique Drosophila melanogaster OAZ homologue is involved in
RT posterior spiracle development.";
RL Dev. Genes Evol. 217:197-208(2007).
CC -!- FUNCTION: Probable transcription factor that can both act as an
CC activator or a repressor depending on the context (By similarity).
CC Involved in posterior spiracle development. Acts downstream of ems and
CC cut in posterior spiracle development. {ECO:0000250,
CC ECO:0000269|PubMed:17323106}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: In embryos, it is expressed in posterior spiracles
CC and peripheral nervous system. {ECO:0000269|PubMed:17323106}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout life. Expressed in embryos,
CC first- and third-instar larvae, late pupae and adults.
CC {ECO:0000269|PubMed:17323106}.
CC -!- DISRUPTION PHENOTYPE: Flies display a structurally abnormal
CC 'filzkoerper' part of the posterior spiracles. They die during larval
CC stage, possibly due to spiracular defects.
CC {ECO:0000269|PubMed:17323106}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL90030.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE013599; AAF58242.2; -; Genomic_DNA.
DR EMBL; AY089292; AAL90030.1; ALT_INIT; mRNA.
DR RefSeq; NP_001097315.1; NM_001103845.3.
DR AlphaFoldDB; A1Z9R4; -.
DR BioGRID; 62359; 10.
DR IntAct; A1Z9R4; 12.
DR STRING; 7227.FBpp0292053; -.
DR PaxDb; A1Z9R4; -.
DR PRIDE; A1Z9R4; -.
DR EnsemblMetazoa; FBtr0302926; FBpp0292052; FBgn0284250.
DR GeneID; 36609; -.
DR KEGG; dme:Dmel_CG42702; -.
DR CTD; 36609; -.
DR FlyBase; FBgn0284250; Oaz.
DR VEuPathDB; VectorBase:FBgn0284250; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162287; -.
DR HOGENOM; CLU_002029_0_0_1; -.
DR InParanoid; A1Z9R4; -.
DR OMA; LACMYCT; -.
DR PhylomeDB; A1Z9R4; -.
DR GenomeRNAi; 36609; -.
DR PRO; PR:A1Z9R4; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0284250; Expressed in embryonic/larval posterior spiracle (Drosophila) and 32 other tissues.
DR ExpressionAtlas; A1Z9R4; baseline and differential.
DR Genevisible; A1Z9R4; DM.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035277; P:spiracle morphogenesis, open tracheal system; IMP:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 21.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 19.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1228
FT /note="Zinc finger protein 423 homolog"
FT /id="PRO_0000308599"
FT ZN_FING 154..176
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 182..204
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 210..232
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 238..260
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 383..406
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 490..512
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 519..541
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 549..573
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 578..601
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 608..631
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 676..699
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 880..903
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 909..931
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 938..960
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 969..991
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1057..1079
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1089..1111
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1118..1140
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 30..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..105
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1201
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1213..1228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1228 AA; 134177 MW; 464D484CFE086BA3 CRC64;
MMALKMLYRG PSSRLENLIE KIQATKEITN NDMYSTHTSS SYSPSISDGT MTPNSHHLIG
APTAAGQEDH PTEGKINGGA DGEDLPKPKR LPHFHHHHHH HYHHQQALKI ANKLRKINKE
AKMGATAGGG ATGAASKFDK LTGEGIKSRG DGSYQCQFCE KTFPRLGYLK HHVQSHAEHL
PFKCEYCSKL FKHKRSRDRH KKLHTNERNY KCPHCEAAFS RSDHLKIHMK THDIQKPFQC
SMCNRGYNTA AALTSHMQKH KKNAAILAAG GNPNALNYSP RSTGSASASV SSNGSLQKRR
YALALASDSS PSRMDFPKRS RSNHVGGTTT TATPTPLLRC SYCPKVTEFS SLEQLNAHLQ
SVHEQPQTQA VKTPVQEGEG FQLSCEYCTM KFGNIAGLFQ HMRSTHMDRL SSPNSYYEHF
NRLATAGTFS PRLALDLPKI KPDLGSPERE SRPAEDDLPT DLSNNKRRPL TPNPQAQTPL
APPSAPPGVF FCNQCNAGLP DFESFRNHLK SHIAEGMQLV CPHCGMSLPE QSEFERHVVG
HFLITGSEFN CSSSCGKSFA KSEDLQQHLL SEHVLTLLKC SLCSELCESR MAMQLHLACA
HSQETKLLRC SACLELFRSD AEFHVHVKTR HQLGGHPTLG ATSSAPTNPL QCMFCRAVCS
SELEMHFHLA AHARQFRCPS CPETFHVEFL LDRHMQSQHG GVKDKEANSP NMGSLYVNAL
LPPLAAAAAA AAATNNNSSI IDYNVAFKGL FGGASGGAGS GGGGAQSGGA PPSANKFYSP
LQVDTNALKA QTSPHPALMY GLSQRYLMEM YAAKSTSPSG NEGVGNSQPP APQATAPPPP
PNASTATFSC GMCERQDLRS EAELHSHRKL AHNLKTGVSL RCAYCAGNFK SRAELEQHMK
SCHNSTGKHK CLICDEVFPS PAILAEHKLQ HSKVGQSGKC SHCGQPLEDV AAFRAHLSEH
GSDGASLPLA CICCRQTLHS EFELSLHAKF HTKSSSSGGS LQEPVCALCL EPLPDATEGP
AKLCDKCCRK HNLNGKRGKH SEPATSLPAP PSAFVENRCN LCKMILPHAQ KLQEHLVEHT
FAGTEQRGFN CYICSAVFTA PGGLLNHMGE HGAHSRPYDC NLCPEKFFFR AELEHHQRGH
ELRPQARPPA AKVEVPSIRN TSPGQSPVRS PTIVKQELYE TDTVESAGVE DEPENHPDEE
EYIEVEQMPH ETRPSGIGSQ LERSTSSA
