ZN426_HUMAN
ID ZN426_HUMAN Reviewed; 554 AA.
AC Q9BUY5; B3KTL2;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Zinc finger protein 426;
GN Name=ZNF426;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9BUY5; Q08043: ACTN3; NbExp=3; IntAct=EBI-743265, EBI-2880652;
CC Q9BUY5; X5D778: ANKRD11; NbExp=3; IntAct=EBI-743265, EBI-17183751;
CC Q9BUY5; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-743265, EBI-742909;
CC Q9BUY5; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-743265, EBI-1166928;
CC Q9BUY5; Q13895: BYSL; NbExp=3; IntAct=EBI-743265, EBI-358049;
CC Q9BUY5; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-743265, EBI-11530605;
CC Q9BUY5; P24863: CCNC; NbExp=3; IntAct=EBI-743265, EBI-395261;
CC Q9BUY5; Q07002: CDK18; NbExp=3; IntAct=EBI-743265, EBI-746238;
CC Q9BUY5; Q96Q77: CIB3; NbExp=3; IntAct=EBI-743265, EBI-10292696;
CC Q9BUY5; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-743265, EBI-11962928;
CC Q9BUY5; Q13115: DUSP4; NbExp=3; IntAct=EBI-743265, EBI-6591081;
CC Q9BUY5; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-743265, EBI-744099;
CC Q9BUY5; Q3B820: FAM161A; NbExp=3; IntAct=EBI-743265, EBI-719941;
CC Q9BUY5; O76003: GLRX3; NbExp=3; IntAct=EBI-743265, EBI-374781;
CC Q9BUY5; P57764: GSDMD; NbExp=3; IntAct=EBI-743265, EBI-2798865;
CC Q9BUY5; Q96MH2: HEXIM2; NbExp=5; IntAct=EBI-743265, EBI-5460660;
CC Q9BUY5; Q7L273: KCTD9; NbExp=3; IntAct=EBI-743265, EBI-4397613;
CC Q9BUY5; P12035: KRT3; NbExp=3; IntAct=EBI-743265, EBI-2430095;
CC Q9BUY5; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-743265, EBI-739832;
CC Q9BUY5; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-743265, EBI-2341787;
CC Q9BUY5; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-743265, EBI-741037;
CC Q9BUY5; Q96A72: MAGOHB; NbExp=4; IntAct=EBI-743265, EBI-746778;
CC Q9BUY5; Q96EH3: MALSU1; NbExp=3; IntAct=EBI-743265, EBI-2339737;
CC Q9BUY5; Q13163: MAP2K5; NbExp=3; IntAct=EBI-743265, EBI-307294;
CC Q9BUY5; Q53F39: MPPE1; NbExp=3; IntAct=EBI-743265, EBI-10242229;
CC Q9BUY5; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-743265, EBI-742948;
CC Q9BUY5; Q8N6N6: NATD1; NbExp=3; IntAct=EBI-743265, EBI-8656665;
CC Q9BUY5; Q96CV9: OPTN; NbExp=4; IntAct=EBI-743265, EBI-748974;
CC Q9BUY5; Q9HBI0: PARVG; NbExp=3; IntAct=EBI-743265, EBI-3921217;
CC Q9BUY5; P40937: RFC5; NbExp=3; IntAct=EBI-743265, EBI-712376;
CC Q9BUY5; Q9H4E5: RHOJ; NbExp=3; IntAct=EBI-743265, EBI-6285694;
CC Q9BUY5; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-743265, EBI-750487;
CC Q9BUY5; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-743265, EBI-744794;
CC Q9BUY5; Q9UHP3: USP25; NbExp=3; IntAct=EBI-743265, EBI-2513462;
CC Q9BUY5; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-743265, EBI-10183064;
CC Q9BUY5; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-743265, EBI-373456;
CC Q9BUY5; Q3MJ62: ZSCAN23; NbExp=3; IntAct=EBI-743265, EBI-5667532;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; AK095759; BAG53124.1; -; mRNA.
DR EMBL; CH471106; EAW84039.1; -; Genomic_DNA.
DR EMBL; BC001791; AAH01791.1; -; mRNA.
DR CCDS; CCDS12215.1; -.
DR RefSeq; NP_001304984.1; NM_001318055.1.
DR RefSeq; NP_001304985.1; NM_001318056.1.
DR RefSeq; NP_077011.1; NM_024106.2.
DR AlphaFoldDB; Q9BUY5; -.
DR SMR; Q9BUY5; -.
DR BioGRID; 122536; 78.
DR IntAct; Q9BUY5; 46.
DR STRING; 9606.ENSP00000439017; -.
DR iPTMnet; Q9BUY5; -.
DR PhosphoSitePlus; Q9BUY5; -.
DR SwissPalm; Q9BUY5; -.
DR BioMuta; ZNF426; -.
DR DMDM; 34925651; -.
DR EPD; Q9BUY5; -.
DR jPOST; Q9BUY5; -.
DR MassIVE; Q9BUY5; -.
DR MaxQB; Q9BUY5; -.
DR PaxDb; Q9BUY5; -.
DR PeptideAtlas; Q9BUY5; -.
DR PRIDE; Q9BUY5; -.
DR ProteomicsDB; 79143; -.
DR Antibodypedia; 12609; 134 antibodies from 23 providers.
DR DNASU; 79088; -.
DR Ensembl; ENST00000253115.7; ENSP00000253115.1; ENSG00000130818.12.
DR Ensembl; ENST00000535489.5; ENSP00000439017.1; ENSG00000130818.12.
DR GeneID; 79088; -.
DR KEGG; hsa:79088; -.
DR MANE-Select; ENST00000253115.7; ENSP00000253115.1; NM_024106.3; NP_077011.1.
DR UCSC; uc002mlq.4; human.
DR CTD; 79088; -.
DR GeneCards; ZNF426; -.
DR HGNC; HGNC:20725; ZNF426.
DR HPA; ENSG00000130818; Low tissue specificity.
DR neXtProt; NX_Q9BUY5; -.
DR OpenTargets; ENSG00000130818; -.
DR PharmGKB; PA134991761; -.
DR VEuPathDB; HostDB:ENSG00000130818; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163292; -.
DR HOGENOM; CLU_002678_44_3_1; -.
DR InParanoid; Q9BUY5; -.
DR OMA; YECEECL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9BUY5; -.
DR TreeFam; TF342172; -.
DR PathwayCommons; Q9BUY5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9BUY5; -.
DR BioGRID-ORCS; 79088; 7 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF426; human.
DR GenomeRNAi; 79088; -.
DR Pharos; Q9BUY5; Tdark.
DR PRO; PR:Q9BUY5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9BUY5; protein.
DR Bgee; ENSG00000130818; Expressed in oocyte and 193 other tissues.
DR ExpressionAtlas; Q9BUY5; baseline and differential.
DR Genevisible; Q9BUY5; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..554
FT /note="Zinc finger protein 426"
FT /id="PRO_0000047576"
FT DOMAIN 42..112
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 146..174
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 224..246
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..302
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 308..330
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 336..358
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..414
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 420..442
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 448..470
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 476..498
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 504..526
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 532..554
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 4
FT /note="A -> V (in dbSNP:rs2042200)"
FT /id="VAR_024214"
FT VARIANT 219
FT /note="T -> A (in dbSNP:rs10420644)"
FT /id="VAR_052824"
SQ SEQUENCE 554 AA; 63106 MW; 8490888CC9537F9C CRC64;
MAAADLSHGH YLSGDPVCLH EEKTPAGRIV ADCLTDCYQD SVTFDDVAVD FTQEEWTLLD
STQRSLYSDV MLENYKNLAT VGGQIIKPSL ISWLEQEESR TVQGGVLQGW EMRLETQWSI
LQQDFLRGQT SIGIQLEGKH NGRELCDCEQ CGEVFSEHSC LKTHVRTQST GNTHDCNQYG
KDFLTLCEKT STGEKLSEFN QSEKIFSLTP NIVYQRTSTQ EKSFECSHCG KSFINESYLQ
AHMRTHNGEK LYEWRNYGPG FIDSTSLSVL IETLNAKKPY KCKECGKGYR YPAYLSIHMR
THTGEKPYEC KECGKAFNYS NSFQIHGRTH TGEKPYVCKE CGKAFTQYSG LSMHVRSHSG
DKPYECKECG KSFLTSSRLI QHIRTHTGEK PFVCVECGKA FAVSSNLSGH LRTHTEEKAC
ECKICGKVFG YPSCLNNHMR THSAQKPYTC KECGKAFNYS THLKIHMRIH TGEKPYECKQ
CGKAFSHSSS FQIHERTHTG EKPYECKECG KAFTCSSSFR IHEKTHTEEK PYKCQQCGKA
YSHPRSLRRH EQIH
