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ZN426_MOUSE
ID   ZN426_MOUSE             Reviewed;         550 AA.
AC   Q8R1D1; Q5DTF7; Q8BJ29; Q8CIG1;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Zinc finger protein 426;
GN   Name=Znf426; Synonyms=Kiaa4237 {ECO:0000312|EMBL:BAD90329.1}, Zfp426;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:BAC39374.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC39374.1};
RC   TISSUE=Lung {ECO:0000312|EMBL:BAC39374.1}, and
RC   Vagina {ECO:0000312|EMBL:BAC29636.1};
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2] {ECO:0000312|EMBL:AAH24805.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N {ECO:0000312|EMBL:AAH23931.1};
RC   TISSUE=Mammary gland {ECO:0000312|EMBL:AAH23931.1}, and Retina;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:BAD90329.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-550.
RC   TISSUE=Fetal brain {ECO:0000312|EMBL:BAD90329.1};
RA   Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA   Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT   complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT   screening of terminal sequences of cDNA clones randomly sampled from size-
RT   fractionated libraries.";
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC29636.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAD90329.1; Type=Miscellaneous discrepancy; Note=Exon deletion.; Evidence={ECO:0000305};
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DR   EMBL; AK036912; BAC29636.1; ALT_INIT; mRNA.
DR   EMBL; AK085144; BAC39374.1; -; mRNA.
DR   EMBL; BC023931; AAH23931.1; -; mRNA.
DR   EMBL; BC024805; AAH24805.1; -; mRNA.
DR   EMBL; AK220563; BAD90329.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS40544.1; -.
DR   RefSeq; NP_001103779.1; NM_001110309.1.
DR   RefSeq; NP_001297671.1; NM_001310742.1.
DR   RefSeq; NP_666333.1; NM_146221.4.
DR   AlphaFoldDB; Q8R1D1; -.
DR   SMR; Q8R1D1; -.
DR   STRING; 10090.ENSMUSP00000127045; -.
DR   iPTMnet; Q8R1D1; -.
DR   PhosphoSitePlus; Q8R1D1; -.
DR   PaxDb; Q8R1D1; -.
DR   PRIDE; Q8R1D1; -.
DR   Antibodypedia; 12609; 134 antibodies from 23 providers.
DR   DNASU; 235028; -.
DR   Ensembl; ENSMUST00000080386; ENSMUSP00000079250; ENSMUSG00000059475.
DR   Ensembl; ENSMUST00000115562; ENSMUSP00000111224; ENSMUSG00000059475.
DR   Ensembl; ENSMUST00000166005; ENSMUSP00000129727; ENSMUSG00000059475.
DR   GeneID; 235028; -.
DR   KEGG; mmu:235028; -.
DR   UCSC; uc009oiq.2; mouse.
DR   CTD; 235028; -.
DR   MGI; MGI:1920248; Zfp426.
DR   VEuPathDB; HostDB:ENSMUSG00000059475; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000163292; -.
DR   HOGENOM; CLU_002678_0_2_1; -.
DR   InParanoid; Q8R1D1; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q8R1D1; -.
DR   Reactome; R-MMU-212436; Generic Transcription Pathway.
DR   BioGRID-ORCS; 235028; 2 hits in 73 CRISPR screens.
DR   ChiTaRS; Zfp426; mouse.
DR   PRO; PR:Q8R1D1; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q8R1D1; protein.
DR   Bgee; ENSMUSG00000059475; Expressed in embryonic brain and 263 other tissues.
DR   ExpressionAtlas; Q8R1D1; baseline and differential.
DR   Genevisible; Q8R1D1; MM.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 10.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..550
FT                   /note="Zinc finger protein 426"
FT                   /id="PRO_0000284700"
FT   DOMAIN          39..110
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         219..241
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         274..296
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         302..324
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         330..352
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         358..380
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         386..408
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         414..436
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         442..464
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         470..492
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         498..522
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         528..550
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   CONFLICT        20
FT                   /note="R -> G (in Ref. 2; AAH23931)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        54
FT                   /note="S -> T (in Ref. 2; AAH23931)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        134
FT                   /note="Missing (in Ref. 2; AAH23931)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        252
FT                   /note="C -> Y (in Ref. 1; BAC29636)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   550 AA;  63020 MW;  1FA8169E2F32A37E CRC64;
     MAAPASSHGP SEDSGCLQER KIAAEMMLVD CLTDDQELVS FEDVIVDFTQ EEWSSLNPDQ
     RNLYRDVMLE NYQNLATVGY QLIKPSLISW LEQEEFSKGQ KIVFPEWKLQ LETKCSAFQQ
     EFLRGNISSR MQMQTGINRG RELCDGTQYG DFFSELSPLR TDMKTQPAQD NYGCSQYRKD
     FLMLQRKNCA GEKLSEFSQS EETGMTPVKE KIDTQEKGFE CSDCGKSFMS QSHLQTHQRT
     HSGDKLYEWN ECGRSFINSR LAVLIETLNA KKPHRCKECG KGYRYPAYLN IHMRTHTGEK
     PYECKECGKA FNYSNSFQIH GRTHTGEKPY VCSQCGKAFT QHSGLSIHVR SHTGDKPYGC
     KECGKAFLTS SRLIQHIRTH TGEKPFVCVK CGKAFAISSN LNGHLKLHAE EKTCECKICG
     KAFGYLSCLN NHMRTHNAKK SYTCKECGKA FNYSTHLKIH MRIHTGEKPY ECKQCGKAFS
     HSTSFQIHER THTGEKPYEC KECGKAFICP SSFRIHEISH THTEEKPYKC QQCGKAYSHP
     RSLRRHERIH
 
 
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