ID   CC70B_DANRE             Reviewed;         249 AA.
AC   A3KNX6; A9C3V9; A9C3W0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=UPF0524 protein C3orf70 homolog B;
GN   Name=c3orf70b {ECO:0000303|PubMed:31623237};
GN   ORFNames=si:dkeyp-30d5.1, zgc:162707;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
RX   PubMed=31623237; DOI=10.3390/ph12040156;
RA   Ashikawa Y., Shiromizu T., Miura K., Adachi Y., Matsui T., Bessho Y.,
RA   Tanaka T., Nishimura Y.;
RT   "C3orf70 Is Involved in Neural and Neurobehavioral Development.";
RL   Pharmaceuticals (Basel) 12:0-0(2019).
CC   -!- FUNCTION: Plays a role in neuronal and neurobehavioral development
CC       (PubMed:31623237). Required for normal expression of the postmitotic
CC       and mature neuron markers elavl3 and eno2 and neurobehaviors related to
CC       circadian rhythm and altered light-dark conditions (PubMed:31623237).
CC       {ECO:0000269|PubMed:31623237}.
CC   -!- DEVELOPMENTAL STAGE: Highly expressed in the gut, myotomes and brain,
CC       especially the midbrain and hindbrain, at 3 days post-fertilization
CC       (dpf). {ECO:0000269|PubMed:31623237}.
CC   -!- DISRUPTION PHENOTYPE: Double knockout of c3orf70a and c3orf70b resulted
CC       in significantly decreased expression of the mature neuron markers
CC       elavl3 and eno2 and the midbrain/hindbrain marker irx3b. Neurobehaviors
CC       related to circadian rhythm and altered light-dark conditions were
CC       significantly impaired. {ECO:0000269|PubMed:31623237}.
CC   -!- SIMILARITY: Belongs to the UPF0524 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP19437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CR936497; CAP19436.1; -; Genomic_DNA.
DR   EMBL; CR936497; CAP19437.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC134060; AAI34061.1; -; mRNA.
DR   RefSeq; NP_001082923.1; NM_001089454.1.
DR   RefSeq; XP_009302777.1; XM_009304502.2.
DR   AlphaFoldDB; A3KNX6; -.
DR   STRING; 7955.ENSDARP00000082632; -.
DR   PaxDb; A3KNX6; -.
DR   Ensembl; ENSDART00000088199; ENSDARP00000082632; ENSDARG00000061664.
DR   Ensembl; ENSDART00000188952; ENSDARP00000155353; ENSDARG00000061664.
DR   GeneID; 100002095; -.
DR   KEGG; dre:100002095; -.
DR   ZFIN; ZDB-GENE-070424-37; zgc:162707.
DR   eggNOG; ENOG502QQSJ; Eukaryota.
DR   GeneTree; ENSGT00390000006618; -.
DR   HOGENOM; CLU_081879_0_0_1; -.
DR   InParanoid; A3KNX6; -.
DR   OMA; GGHFLES; -.
DR   OrthoDB; 1244564at2759; -.
DR   PhylomeDB; A3KNX6; -.
DR   TreeFam; TF328625; -.
DR   PRO; PR:A3KNX6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000061664; Expressed in head and 17 other tissues.
DR   ExpressionAtlas; A3KNX6; baseline and differential.
DR   GO; GO:0048512; P:circadian behavior; IMP:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR   InterPro; IPR029670; UPF0524_fam.
DR   PANTHER; PTHR31785; PTHR31785; 1.
DR   Pfam; PF15823; UPF0524; 1.
PE   2: Evidence at transcript level;
KW   Neurogenesis; Reference proteome.
FT   CHAIN           1..249
FT                   /note="UPF0524 protein C3orf70 homolog B"
FT                   /id="PRO_0000319979"
FT   REGION          174..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        56
FT                   /note="Y -> H (in Ref. 2; AAI34061)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        110
FT                   /note="A -> P (in Ref. 2; AAI34061)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   249 AA;  27461 MW;  056F5D0618EFAFFF CRC64;
     MAYSGAQKAL KSDKLDEAQA LAKSCAGRPD FLPCDGLSIC ATHSHGKCFK LHWCCYLGWC
     HCKYVYQPMT NVAQLPSTPV PAAPSDCPDT IDLSISLTER FLRISPCFQA PPCPESPKYC
     NIAELFIDDY IVKRINGKMC YVQRPQAHVE PAQMNPIQKQ HTEDKQIVEE TVKGPKMGHC
     SSPSTSEDSG INALGGHFLE SCEEESEEED ELSTDGHSSP GSLWDQDECT LLSPSKSMVE
     IIENIETTV