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ZN426_RAT
ID   ZN426_RAT               Reviewed;         553 AA.
AC   A1L1L7;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Zinc finger protein 426;
GN   Name=Znf426; Synonyms=Zfp426;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAI29126.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis {ECO:0000312|EMBL:AAI29126.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC129125; AAI29126.1; -; mRNA.
DR   RefSeq; NP_001073412.1; NM_001079943.1.
DR   RefSeq; XP_006242728.1; XM_006242666.1.
DR   RefSeq; XP_006242729.1; XM_006242667.3.
DR   RefSeq; XP_006242730.1; XM_006242668.3.
DR   RefSeq; XP_006242732.1; XM_006242670.2.
DR   RefSeq; XP_008764203.1; XM_008765981.2.
DR   AlphaFoldDB; A1L1L7; -.
DR   SMR; A1L1L7; -.
DR   STRING; 10116.ENSRNOP00000038875; -.
DR   PaxDb; A1L1L7; -.
DR   Ensembl; ENSRNOT00000117071; ENSRNOP00000084731; ENSRNOG00000033624.
DR   GeneID; 690895; -.
DR   KEGG; rno:690895; -.
DR   UCSC; RGD:1308643; rat.
DR   CTD; 235028; -.
DR   RGD; 1308643; Zfp426.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000163292; -.
DR   HOGENOM; CLU_002678_0_2_1; -.
DR   InParanoid; A1L1L7; -.
DR   OMA; YECEECL; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; A1L1L7; -.
DR   TreeFam; TF342172; -.
DR   Reactome; R-RNO-212436; Generic Transcription Pathway.
DR   PRO; PR:A1L1L7; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000033624; Expressed in cerebellum and 20 other tissues.
DR   ExpressionAtlas; A1L1L7; baseline and differential.
DR   Genevisible; A1L1L7; RN.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 10.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..553
FT                   /note="Zinc finger protein 426"
FT                   /id="PRO_0000284701"
FT   DOMAIN          40..111
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         222..244
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         277..299
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         305..327
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         333..355
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         361..383
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         389..411
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         417..439
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         445..467
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         473..495
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         501..525
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         531..553
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   553 AA;  63005 MW;  358C5C0EFB5BA73C CRC64;
     MAAPDSLSHG PSGDSVCLQE EKVSAEMMLV DCLTNYQELV SFDDVIVDFT QEEWTSLNPD
     QRTLYREVML ENYKNLATVG YQLIKPSVIS WLEQEEFSTG QKIVFPEWKI QLETQCSASQ
     QELLRGNISN GMQTQTGSDT GRGLCDGTQY GDFFSELSPL RTVMKTRPAQ DNYDSSQCRK
     DFLMLQRKKC AGEKLSEFNQ SEETGAIPGK AYQKMATQEK CFECSDCGKS FMNQSHLQTH
     QRTHSGDKLY ELNECGRSFI NSRLAVLIET LNAKKPHRCK ECGKGYRYPA YLNIHMRTHT
     GEKPYECKEC GKAFNYSNSF QIHGRTHTGE KPYVCNQCGK AFTQHSGLSI HVRSHNGDKP
     YACKECGKAF LTSSRLIQHI RTHTGEKPFV CVKCGKAFAI SSNLNGHLKM HAEEKTCECK
     ICGKAFGYLS CLNNHMRTHN AKKSYTCKEC GKAFNYSTHL KIHMRIHTGE KPYECKQCGK
     AFSHSTSFQI HERTHTGEKP YECKECGKAF ICPSSFRIHE ISHTHTEEKP YKCQQCGKAY
     SHPRSLRRHE RIH
 
 
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