ZN426_RAT
ID ZN426_RAT Reviewed; 553 AA.
AC A1L1L7;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Zinc finger protein 426;
GN Name=Znf426; Synonyms=Zfp426;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAI29126.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis {ECO:0000312|EMBL:AAI29126.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; BC129125; AAI29126.1; -; mRNA.
DR RefSeq; NP_001073412.1; NM_001079943.1.
DR RefSeq; XP_006242728.1; XM_006242666.1.
DR RefSeq; XP_006242729.1; XM_006242667.3.
DR RefSeq; XP_006242730.1; XM_006242668.3.
DR RefSeq; XP_006242732.1; XM_006242670.2.
DR RefSeq; XP_008764203.1; XM_008765981.2.
DR AlphaFoldDB; A1L1L7; -.
DR SMR; A1L1L7; -.
DR STRING; 10116.ENSRNOP00000038875; -.
DR PaxDb; A1L1L7; -.
DR Ensembl; ENSRNOT00000117071; ENSRNOP00000084731; ENSRNOG00000033624.
DR GeneID; 690895; -.
DR KEGG; rno:690895; -.
DR UCSC; RGD:1308643; rat.
DR CTD; 235028; -.
DR RGD; 1308643; Zfp426.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163292; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; A1L1L7; -.
DR OMA; YECEECL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A1L1L7; -.
DR TreeFam; TF342172; -.
DR Reactome; R-RNO-212436; Generic Transcription Pathway.
DR PRO; PR:A1L1L7; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000033624; Expressed in cerebellum and 20 other tissues.
DR ExpressionAtlas; A1L1L7; baseline and differential.
DR Genevisible; A1L1L7; RN.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..553
FT /note="Zinc finger protein 426"
FT /id="PRO_0000284701"
FT DOMAIN 40..111
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 222..244
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 277..299
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 305..327
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 333..355
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 361..383
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 389..411
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 417..439
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 445..467
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 473..495
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 501..525
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 531..553
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 553 AA; 63005 MW; 358C5C0EFB5BA73C CRC64;
MAAPDSLSHG PSGDSVCLQE EKVSAEMMLV DCLTNYQELV SFDDVIVDFT QEEWTSLNPD
QRTLYREVML ENYKNLATVG YQLIKPSVIS WLEQEEFSTG QKIVFPEWKI QLETQCSASQ
QELLRGNISN GMQTQTGSDT GRGLCDGTQY GDFFSELSPL RTVMKTRPAQ DNYDSSQCRK
DFLMLQRKKC AGEKLSEFNQ SEETGAIPGK AYQKMATQEK CFECSDCGKS FMNQSHLQTH
QRTHSGDKLY ELNECGRSFI NSRLAVLIET LNAKKPHRCK ECGKGYRYPA YLNIHMRTHT
GEKPYECKEC GKAFNYSNSF QIHGRTHTGE KPYVCNQCGK AFTQHSGLSI HVRSHNGDKP
YACKECGKAF LTSSRLIQHI RTHTGEKPFV CVKCGKAFAI SSNLNGHLKM HAEEKTCECK
ICGKAFGYLS CLNNHMRTHN AKKSYTCKEC GKAFNYSTHL KIHMRIHTGE KPYECKQCGK
AFSHSTSFQI HERTHTGEKP YECKECGKAF ICPSSFRIHE ISHTHTEEKP YKCQQCGKAY
SHPRSLRRHE RIH