ID   ZN428_HUMAN             Reviewed;         188 AA.
AC   Q96B54; O95054; Q6X3Y3;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Zinc finger protein 428;
DE   AltName: Full=Enzyme-like protein PIT13;
GN   Name=ZNF428; Synonyms=C19orf37;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-109.
RA   Hu Q.-D., Huo K., Yuan H., Lu H., Li Y.-Y.;
RT   "Cloning and mapping of a novel human gene.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-108, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- INTERACTION:
CC       Q96B54; P09429: HMGB1; NbExp=3; IntAct=EBI-9995882, EBI-389432;
CC       Q96B54; P26583: HMGB2; NbExp=4; IntAct=EBI-9995882, EBI-1057009;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC99795.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAP87382.1; Type=Miscellaneous discrepancy; Note=Intron retention at the C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC006276; AAC99795.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH471126; EAW57210.1; -; Genomic_DNA.
DR   EMBL; BC015950; AAH15950.2; -; mRNA.
DR   EMBL; AY257197; AAP87382.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS12626.1; -.
DR   RefSeq; NP_872304.2; NM_182498.3.
DR   AlphaFoldDB; Q96B54; -.
DR   BioGRID; 125976; 25.
DR   IntAct; Q96B54; 17.
DR   STRING; 9606.ENSP00000300811; -.
DR   iPTMnet; Q96B54; -.
DR   PhosphoSitePlus; Q96B54; -.
DR   BioMuta; ZNF428; -.
DR   DMDM; 74760720; -.
DR   EPD; Q96B54; -.
DR   jPOST; Q96B54; -.
DR   MassIVE; Q96B54; -.
DR   MaxQB; Q96B54; -.
DR   PaxDb; Q96B54; -.
DR   PeptideAtlas; Q96B54; -.
DR   PRIDE; Q96B54; -.
DR   ProteomicsDB; 76046; -.
DR   Antibodypedia; 31091; 87 antibodies from 15 providers.
DR   DNASU; 126299; -.
DR   Ensembl; ENST00000300811.8; ENSP00000300811.2; ENSG00000131116.12.
DR   GeneID; 126299; -.
DR   KEGG; hsa:126299; -.
DR   MANE-Select; ENST00000300811.8; ENSP00000300811.2; NM_182498.4; NP_872304.2.
DR   UCSC; uc002oxa.4; human.
DR   CTD; 126299; -.
DR   DisGeNET; 126299; -.
DR   GeneCards; ZNF428; -.
DR   HGNC; HGNC:20804; ZNF428.
DR   HPA; ENSG00000131116; Low tissue specificity.
DR   neXtProt; NX_Q96B54; -.
DR   OpenTargets; ENSG00000131116; -.
DR   PharmGKB; PA142672216; -.
DR   VEuPathDB; HostDB:ENSG00000131116; -.
DR   eggNOG; ENOG502T3CS; Eukaryota.
DR   GeneTree; ENSGT00390000006595; -.
DR   HOGENOM; CLU_1421044_0_0_1; -.
DR   InParanoid; Q96B54; -.
DR   OMA; EGGAYHC; -.
DR   OrthoDB; 1559423at2759; -.
DR   PhylomeDB; Q96B54; -.
DR   TreeFam; TF337528; -.
DR   PathwayCommons; Q96B54; -.
DR   SignaLink; Q96B54; -.
DR   BioGRID-ORCS; 126299; 12 hits in 1075 CRISPR screens.
DR   GenomeRNAi; 126299; -.
DR   Pharos; Q96B54; Tdark.
DR   PRO; PR:Q96B54; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q96B54; protein.
DR   Bgee; ENSG00000131116; Expressed in cortical plate and 137 other tissues.
DR   ExpressionAtlas; Q96B54; baseline and differential.
DR   Genevisible; Q96B54; HS.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR038977; ZNF428.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR36862; PTHR36862; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   1: Evidence at protein level;
KW   Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..188
FT                   /note="Zinc finger protein 428"
FT                   /id="PRO_0000312346"
FT   ZN_FING         161..183
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..59
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..148
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         108
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
SQ   SEQUENCE   188 AA;  20481 MW;  31681A8EFE3876F2 CRC64;
     MTETREPAET GGYASLEEDD EDLSPGPEHS SDSEYTLSEP DSEEEEDEEE EEEETTDDPE
     YDPGYKVKQR LGGGRGGPSR RAPRAAQPPA QPCQLCGRSP LGEAPPGTPP CRLCCPATAP
     QEAPAPEGRA LGEEEEEPPR AGEGRPAGRE EEEEEEEEGT YHCTECEDSF DNLGELHGHF
     MLHARGEV