ZN428_MOUSE
ID ZN428_MOUSE Reviewed; 176 AA.
AC Q8C1M2; Q4V9V1; Q8QZT0;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Zinc finger protein 428;
GN Name=Znf428; Synonyms=Zfp428;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Eye, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK010415; BAC25296.1; -; mRNA.
DR EMBL; AK139174; BAE23910.1; -; mRNA.
DR EMBL; BC024802; AAH24802.1; -; mRNA.
DR EMBL; BC096675; AAH96675.1; -; mRNA.
DR CCDS; CCDS20952.1; -.
DR RefSeq; NP_001277390.1; NM_001290461.1.
DR RefSeq; NP_666295.2; NM_146183.2.
DR RefSeq; NP_780351.1; NM_175142.1.
DR RefSeq; XP_017177645.1; XM_017322156.1.
DR AlphaFoldDB; Q8C1M2; -.
DR BioGRID; 231334; 1.
DR STRING; 10090.ENSMUSP00000071318; -.
DR iPTMnet; Q8C1M2; -.
DR PhosphoSitePlus; Q8C1M2; -.
DR EPD; Q8C1M2; -.
DR MaxQB; Q8C1M2; -.
DR PaxDb; Q8C1M2; -.
DR PRIDE; Q8C1M2; -.
DR Antibodypedia; 31091; 87 antibodies from 15 providers.
DR DNASU; 232969; -.
DR Ensembl; ENSMUST00000071361; ENSMUSP00000071318; ENSMUSG00000064264.
DR GeneID; 232969; -.
DR KEGG; mmu:232969; -.
DR UCSC; uc009fpu.2; mouse.
DR CTD; 232969; -.
DR MGI; MGI:1916463; Zfp428.
DR VEuPathDB; HostDB:ENSMUSG00000064264; -.
DR eggNOG; ENOG502T3CS; Eukaryota.
DR GeneTree; ENSGT00390000006595; -.
DR InParanoid; Q8C1M2; -.
DR PhylomeDB; Q8C1M2; -.
DR TreeFam; TF337528; -.
DR BioGRID-ORCS; 232969; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q8C1M2; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C1M2; protein.
DR Bgee; ENSMUSG00000064264; Expressed in cortical plate and 196 other tissues.
DR ExpressionAtlas; Q8C1M2; baseline and differential.
DR Genevisible; Q8C1M2; MM.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR038977; ZNF428.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR36862; PTHR36862; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..176
FT /note="Zinc finger protein 428"
FT /id="PRO_0000312347"
FT ZN_FING 149..171
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..44
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 96
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q96B54"
FT CONFLICT 90
FT /note="G -> R (in Ref. 2; AAH24802)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="T -> N (in Ref. 2; AAH96675)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 176 AA; 19003 MW; 6F61DBBADB5841DC CRC64;
MTETREPTET GGYASLEEDD EDLSPEPDSE EEEEEEEEET TDDPEYDPGY KVKQRIGGGR
GGPSRRAPRA TQPAGPPAQP CQLCGRSALG EAPPGTPPCR LCCPATATQE APGPESRALG
EEEEEPSRTG ETRPAGRDGD EDEEEGGTYH CTECEDSFDN LGELHGHFML HARGEV
