ZN429_HUMAN
ID ZN429_HUMAN Reviewed; 674 AA.
AC Q86V71; A6NLV7; Q9BZE6;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger protein 429;
GN Name=ZNF429;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-623.
RA Bi A.;
RT "Zinc finger protein weakly similar to zinc finger protein 85.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-497.
RX PubMed=7865130; DOI=10.1089/dna.1995.14.125;
RA Abrink M., Aveskogh M., Hellman L.;
RT "Isolation of cDNA clones for 42 different Kruppel-related zinc finger
RT proteins expressed in the human monoblast cell line U-937.";
RL DNA Cell Biol. 14:125-136(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 545-674.
RC TISSUE=Chondrosarcoma;
RG The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK01422.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAK01422.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
CC Sequence=AAP30884.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAP30884.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
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DR EMBL; AC010615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY269786; AAP30884.1; ALT_SEQ; mRNA.
DR EMBL; AF325191; AAK01422.1; ALT_SEQ; mRNA.
DR EMBL; BM996292; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS42537.1; -.
DR RefSeq; NP_001001415.2; NM_001001415.3.
DR AlphaFoldDB; Q86V71; -.
DR SMR; Q86V71; -.
DR STRING; 9606.ENSP00000351280; -.
DR iPTMnet; Q86V71; -.
DR PhosphoSitePlus; Q86V71; -.
DR BioMuta; ZNF429; -.
DR DMDM; 218511972; -.
DR jPOST; Q86V71; -.
DR MassIVE; Q86V71; -.
DR MaxQB; Q86V71; -.
DR PaxDb; Q86V71; -.
DR PeptideAtlas; Q86V71; -.
DR PRIDE; Q86V71; -.
DR Antibodypedia; 44155; 70 antibodies from 13 providers.
DR DNASU; 353088; -.
DR Ensembl; ENST00000358491.9; ENSP00000351280.3; ENSG00000197013.11.
DR GeneID; 353088; -.
DR KEGG; hsa:353088; -.
DR MANE-Select; ENST00000358491.9; ENSP00000351280.3; NM_001001415.4; NP_001001415.2.
DR UCSC; uc002nqd.2; human.
DR CTD; 353088; -.
DR DisGeNET; 353088; -.
DR GeneCards; ZNF429; -.
DR HGNC; HGNC:20817; ZNF429.
DR HPA; ENSG00000197013; Low tissue specificity.
DR neXtProt; NX_Q86V71; -.
DR OpenTargets; ENSG00000197013; -.
DR PharmGKB; PA134910790; -.
DR VEuPathDB; HostDB:ENSG00000197013; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153165; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q86V71; -.
DR OMA; CKKCFAD; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q86V71; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q86V71; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 353088; 38 hits in 1035 CRISPR screens.
DR ChiTaRS; ZNF429; human.
DR GenomeRNAi; 353088; -.
DR Pharos; Q86V71; Tdark.
DR PRO; PR:Q86V71; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q86V71; protein.
DR Bgee; ENSG00000197013; Expressed in C1 segment of cervical spinal cord and 126 other tissues.
DR ExpressionAtlas; Q86V71; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 15.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 17.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..674
FT /note="Zinc finger protein 429"
FT /id="PRO_0000047577"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 145..167
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 173..195
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 10; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 565..587
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 593..615
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 621..643
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 653..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 605
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P17019"
FT VARIANT 650
FT /note="H -> Y (in dbSNP:rs2562473)"
FT /id="VAR_047848"
FT CONFLICT 167
FT /note="H -> Y (in Ref. 2; AAP30884 and 3; AAK01422)"
FT /evidence="ECO:0000305"
FT CONFLICT 206..207
FT /note="FG -> CC (in Ref. 2; AAP30884 and 3; AAK01422)"
FT /evidence="ECO:0000305"
FT CONFLICT 249..276
FT /note="Missing (in Ref. 2; AAP30884 and 3; AAK01422)"
FT /evidence="ECO:0000305"
FT CONFLICT 252
FT /note="T -> S (in Ref. 2; AAP30884 and 3; AAK01422)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="G -> V (in Ref. 2; AAP30884 and 3; AAK01422)"
FT /evidence="ECO:0000305"
FT CONFLICT 361
FT /note="V -> I (in Ref. 2; AAP30884 and 3; AAK01422)"
FT /evidence="ECO:0000305"
FT CONFLICT 367
FT /note="K -> N (in Ref. 3; AAK01422)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 674 AA; 78152 MW; C48BC76B58059FE7 CRC64;
MGPLTFTDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSKP DLITCLEKEK
EPCKMKRHEM VDEPPVVCSH FAEDFWPEQD IKDSFQKVTL RRYDKRGHEN LQLRKGYKTV
GDCKLYKGGY NGLNQCLTLT QSKMYHCDIY VKVFYAFSNA DRYKTRHTGK KPFQCKKCGK
SFCMLSQLTQ HKKIHIRENT YRCKEFGNAF NQSSALTNHK RIYVGEKHYR CEECGKAFNH
YSTLTNHKRI HTGEKPYKCK ECGKAFSRYS TLTTHKRIHS GEKPYKCDEC GKTFSISSTF
TKHKIIHTEE KPYKCKECGK AFNRSSTLTS HKRIHTGEKP YKCEECGKAF NWSSTLTKHK
VIHTGEKPYK CEECGKAFNQ SSRLTRHKKI HTGEEPYKFE KCGRVFTCSS TLTQDKKIHT
GEKPYNCEEC GKVFTYSSTL TRHKRIHTEE KPYKCNECGK AFNRSSHLTS HRRIHTGEKP
YKCEECGKAF KQSSNLNSHK KIHSGEKPYK CEECGKAFIL SSRLTQHKKI HTGEKPYKCE
ECGKAFNRSS RLTQHKKIHT GEKPYKCKQC DKAFTHSSNL SSHKKIHSGE KPYKCEECGK
AFNRSSRLTQ HKKIHTREKP YKCEECAKAF TRSSRLTQHK KIHRMGVVAH ACNPSTLGGR
GGRITRSGDR DRPG
