ZN432_HUMAN
ID ZN432_HUMAN Reviewed; 652 AA.
AC O94892;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Zinc finger protein 432;
GN Name=ZNF432; Synonyms=KIAA0798;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XI. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:277-286(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NITRATION [LARGE SCALE ANALYSIS] AT TYR-41, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pituitary adenoma;
RX PubMed=16777052; DOI=10.1016/j.ab.2006.05.024;
RA Zhan X., Desiderio D.M.;
RT "Nitroproteins from a human pituitary adenoma tissue discovered with a
RT nitrotyrosine affinity column and tandem mass spectrometry.";
RL Anal. Biochem. 354:279-289(2006).
RN [4]
RP VARIANTS [LARGE SCALE ANALYSIS] VAL-416 AND TYR-490.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC O94892; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-12121104, EBI-10303987;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA34518.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB018341; BAA34518.2; ALT_INIT; mRNA.
DR EMBL; BC002858; AAH02858.1; -; mRNA.
DR CCDS; CCDS12848.1; -.
DR RefSeq; NP_001309213.1; NM_001322284.1.
DR RefSeq; NP_001309214.1; NM_001322285.1.
DR RefSeq; NP_055465.1; NM_014650.3.
DR AlphaFoldDB; O94892; -.
DR SMR; O94892; -.
DR BioGRID; 115023; 5.
DR IntAct; O94892; 4.
DR STRING; 9606.ENSP00000470488; -.
DR GlyConnect; 2092; 1 N-Linked glycan (1 site).
DR GlyGen; O94892; 1 site, 2 N-linked glycans (1 site).
DR iPTMnet; O94892; -.
DR PhosphoSitePlus; O94892; -.
DR BioMuta; ZNF432; -.
DR jPOST; O94892; -.
DR MassIVE; O94892; -.
DR MaxQB; O94892; -.
DR PaxDb; O94892; -.
DR PeptideAtlas; O94892; -.
DR PRIDE; O94892; -.
DR ProteomicsDB; 50529; -.
DR Antibodypedia; 56944; 88 antibodies from 14 providers.
DR DNASU; 9668; -.
DR Ensembl; ENST00000221315.10; ENSP00000221315.4; ENSG00000256087.7.
DR Ensembl; ENST00000594154.5; ENSP00000470488.1; ENSG00000256087.7.
DR GeneID; 9668; -.
DR KEGG; hsa:9668; -.
DR MANE-Select; ENST00000221315.10; ENSP00000221315.4; NM_014650.4; NP_055465.1.
DR UCSC; uc002pyk.4; human.
DR CTD; 9668; -.
DR DisGeNET; 9668; -.
DR GeneCards; ZNF432; -.
DR HGNC; HGNC:20810; ZNF432.
DR HPA; ENSG00000256087; Low tissue specificity.
DR neXtProt; NX_O94892; -.
DR OpenTargets; ENSG00000256087; -.
DR PharmGKB; PA134935907; -.
DR VEuPathDB; HostDB:ENSG00000256087; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163119; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; O94892; -.
DR OMA; ICSECFP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; O94892; -.
DR TreeFam; TF350804; -.
DR PathwayCommons; O94892; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; O94892; -.
DR BioGRID-ORCS; 9668; 10 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF432; human.
DR GenomeRNAi; 9668; -.
DR Pharos; O94892; Tdark.
DR PRO; PR:O94892; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O94892; protein.
DR Bgee; ENSG00000256087; Expressed in endothelial cell and 193 other tissues.
DR ExpressionAtlas; O94892; baseline and differential.
DR Genevisible; O94892; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 15.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nitration; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..652
FT /note="Zinc finger protein 432"
FT /id="PRO_0000047580"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 205..227
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 233..255
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 261..283
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 289..311
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 317..339
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 345..367
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 373..395
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 401..423
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 429..451
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 457..479
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 485..507
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 513..535
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 541..563
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 567..591
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 597..619
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 625..647
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 41
FT /note="3'-nitrotyrosine"
FT /evidence="ECO:0007744|PubMed:16777052"
FT VARIANT 416
FT /note="L -> V (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035577"
FT VARIANT 490
FT /note="C -> Y (in a breast cancer sample; somatic mutation;
FT dbSNP:rs755035378)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035578"
SQ SEQUENCE 652 AA; 74836 MW; 14B61461EE54A6EB CRC64;
MINAQELLTL EDVTVEFTWE EWQLLGPFQK DLYRDVMLEI YSNLLSMGYQ VSKPDALSKL
ERGEEPWTME DERHSRICPE NNEVDDHLQD HLENQRMLKS VEQYHEHNAF GNTASQTKSL
CLFRENHDTF ELYIKTLKSN LSLVNQNKSC EINNSTKFSG DGKSFLHGNY EELYSAAKFS
VSTKANSTKS QVSKHQRTHE IEKNHVCSEC GKAFVKKSQL TDHERVHTGE KPYGCTLCAK
VFSRKSRLNE HQRIHKREKS FICSECGKVF TMKSRLIEHQ RTHTGEKPYI CNECGKGFPG
KRNLIVHQRN HTGEKSYICS ECGKGFTGKS MLIIHQRTHT GEKPYICSEC GKGFTTKHYV
IIHQRNHTGE KPYICNECGK GFTMKSRMIE HQRTHTGEKP YICSECGKGF PRKSNLIVHQ
RNHTVEKSYL CSECGKGFTV KSMLIIHQRT HTGEKPYTCS ECGKGFPLKS RLIVHQRTHT
GEKPYRCSEC GKGFIVNSGL MLHQRTHTGE KPYICNECGK GFAFKSNLVV HQRTHTGEKP
FMCSECGKGF TMKRYLIVHQ QIHTEEKSCI CSECGRGFAK ETELALHKQV HTGEKPYGCN
ECGKGFTMKS RLIVHQRTHT GEKPFVCSEC RKAFSSKRNL IVHQRTHNGN KP
