ZN438_HUMAN
ID ZN438_HUMAN Reviewed; 828 AA.
AC Q7Z4V0; A2A3J4; A8K9L5; Q5T426; Q658Q4; Q6ZN65;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Zinc finger protein 438;
GN Name=ZNF438;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Zhong C.M., Wan B., Yu L.;
RT "Cloning and characterization of a novel human C2H2 zinc finger gene,
RT ZNF438.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Guo J.H., She X.Y., Yu L.;
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP SER-173.
RC TISSUE=Kidney, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT SER-173.
RC TISSUE=Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP VARIANT [LARGE SCALE ANALYSIS] ASN-381.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [8]
RP FUNCTION (ISOFORM 1), SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=17669267; DOI=10.5483/bmbrep.2007.40.4.517;
RA Zhong Z., Wan B., Qiu Y., Ni J., Tang W., Chen X., Yang Y., Shen S.,
RA Wang Y., Bai M., Lang Q., Yu L.;
RT "Identification of a novel human zinc finger gene, ZNF438, with
RT transcription inhibition activity.";
RL J. Biochem. Mol. Biol. 40:517-524(2007).
CC -!- FUNCTION: Isoform 1 acts as a transcriptional repressor.
CC -!- INTERACTION:
CC Q7Z4V0; O00154-4: ACOT7; NbExp=3; IntAct=EBI-11962468, EBI-12007918;
CC Q7Z4V0; Q9BYV9: BACH2; NbExp=3; IntAct=EBI-11962468, EBI-1642333;
CC Q7Z4V0; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-11962468, EBI-11524452;
CC Q7Z4V0; Q96PG8: BBC3; NbExp=3; IntAct=EBI-11962468, EBI-17289784;
CC Q7Z4V0; Q13895: BYSL; NbExp=3; IntAct=EBI-11962468, EBI-358049;
CC Q7Z4V0; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-11962468, EBI-5278764;
CC Q7Z4V0; Q07002: CDK18; NbExp=3; IntAct=EBI-11962468, EBI-746238;
CC Q7Z4V0; Q96LK0: CEP19; NbExp=3; IntAct=EBI-11962468, EBI-741885;
CC Q7Z4V0; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11962468, EBI-3867333;
CC Q7Z4V0; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11962468, EBI-9679045;
CC Q7Z4V0; Q96FX2: DPH3; NbExp=3; IntAct=EBI-11962468, EBI-465363;
CC Q7Z4V0; P62508-3: ESRRG; NbExp=3; IntAct=EBI-11962468, EBI-12001340;
CC Q7Z4V0; O95363: FARS2; NbExp=3; IntAct=EBI-11962468, EBI-2513774;
CC Q7Z4V0; O43559: FRS3; NbExp=3; IntAct=EBI-11962468, EBI-725515;
CC Q7Z4V0; P51114-2: FXR1; NbExp=3; IntAct=EBI-11962468, EBI-11022345;
CC Q7Z4V0; Q08379: GOLGA2; NbExp=3; IntAct=EBI-11962468, EBI-618309;
CC Q7Z4V0; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11962468, EBI-5916454;
CC Q7Z4V0; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-11962468, EBI-11956675;
CC Q7Z4V0; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-11962468, EBI-14103818;
CC Q7Z4V0; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-11962468, EBI-11954971;
CC Q7Z4V0; Q6A162: KRT40; NbExp=3; IntAct=EBI-11962468, EBI-10171697;
CC Q7Z4V0; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-11962468, EBI-10274069;
CC Q7Z4V0; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-11962468, EBI-746778;
CC Q7Z4V0; P23508: MCC; NbExp=3; IntAct=EBI-11962468, EBI-307531;
CC Q7Z4V0; Q99750: MDFI; NbExp=3; IntAct=EBI-11962468, EBI-724076;
CC Q7Z4V0; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-11962468, EBI-10172526;
CC Q7Z4V0; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-11962468, EBI-10288852;
CC Q7Z4V0; Q6PF18: MORN3; NbExp=3; IntAct=EBI-11962468, EBI-9675802;
CC Q7Z4V0; Q9Y3B7: MRPL11; NbExp=3; IntAct=EBI-11962468, EBI-5453723;
CC Q7Z4V0; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-11962468, EBI-11522433;
CC Q7Z4V0; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-11962468, EBI-6952711;
CC Q7Z4V0; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-11962468, EBI-11750983;
CC Q7Z4V0; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-11962468, EBI-398874;
CC Q7Z4V0; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-11962468, EBI-14066006;
CC Q7Z4V0; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-11962468, EBI-79165;
CC Q7Z4V0; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-11962468, EBI-10232538;
CC Q7Z4V0; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-11962468, EBI-12014286;
CC Q7Z4V0; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-11962468, EBI-302345;
CC Q7Z4V0; Q9NVM4: PRMT7; NbExp=3; IntAct=EBI-11962468, EBI-3215577;
CC Q7Z4V0; P20618: PSMB1; NbExp=3; IntAct=EBI-11962468, EBI-372273;
CC Q7Z4V0; Q15276: RABEP1; NbExp=3; IntAct=EBI-11962468, EBI-447043;
CC Q7Z4V0; Q6P9E2: RECK; NbExp=3; IntAct=EBI-11962468, EBI-10253121;
CC Q7Z4V0; Q9BUL9: RPP25; NbExp=3; IntAct=EBI-11962468, EBI-366570;
CC Q7Z4V0; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-11962468, EBI-748391;
CC Q7Z4V0; Q01105-2: SET; NbExp=3; IntAct=EBI-11962468, EBI-7481343;
CC Q7Z4V0; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-11962468, EBI-358489;
CC Q7Z4V0; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-11962468, EBI-12023934;
CC Q7Z4V0; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-11962468, EBI-2212028;
CC Q7Z4V0; O43463: SUV39H1; NbExp=3; IntAct=EBI-11962468, EBI-349968;
CC Q7Z4V0; Q9BSW7: SYT17; NbExp=3; IntAct=EBI-11962468, EBI-745392;
CC Q7Z4V0; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-11962468, EBI-8787464;
CC Q7Z4V0; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-11962468, EBI-11952721;
CC Q7Z4V0; Q12933: TRAF2; NbExp=3; IntAct=EBI-11962468, EBI-355744;
CC Q7Z4V0; P0DI81-3: TRAPPC2; NbExp=3; IntAct=EBI-11962468, EBI-11961968;
CC Q7Z4V0; Q86XT4: TRIM50; NbExp=3; IntAct=EBI-11962468, EBI-9867283;
CC Q7Z4V0; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-11962468, EBI-744794;
CC Q7Z4V0; Q5T7W7: TSTD2; NbExp=3; IntAct=EBI-11962468, EBI-8994397;
CC Q7Z4V0; P07947: YES1; NbExp=3; IntAct=EBI-11962468, EBI-515331;
CC Q7Z4V0; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-11962468, EBI-742740;
CC Q7Z4V0; P52747: ZNF143; NbExp=3; IntAct=EBI-11962468, EBI-2849334;
CC Q7Z4V0; P17021: ZNF17; NbExp=3; IntAct=EBI-11962468, EBI-1105334;
CC Q7Z4V0; O95125: ZNF202; NbExp=3; IntAct=EBI-11962468, EBI-751960;
CC Q7Z4V0; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-11962468, EBI-11035148;
CC Q7Z4V0; Q9UEG4: ZNF629; NbExp=3; IntAct=EBI-11962468, EBI-9977294;
CC Q7Z4V0; Q5T619: ZNF648; NbExp=3; IntAct=EBI-11962468, EBI-11985915;
CC Q7Z4V0; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-11962468, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17669267}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7Z4V0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z4V0-2; Sequence=VSP_019800;
CC Name=3;
CC IsoId=Q7Z4V0-3; Sequence=VSP_019799;
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:17669267}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ356012; ABC86955.1; -; mRNA.
DR EMBL; DQ356011; ABC86954.1; -; mRNA.
DR EMBL; AF428258; AAP97298.1; -; mRNA.
DR EMBL; AK131357; BAD18510.1; -; mRNA.
DR EMBL; AK292730; BAF85419.1; -; mRNA.
DR EMBL; AL833056; CAH56317.1; -; mRNA.
DR EMBL; AL359532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104757; AAI04758.1; -; mRNA.
DR EMBL; BC101622; AAI01623.1; -; mRNA.
DR CCDS; CCDS44369.1; -. [Q7Z4V0-2]
DR CCDS; CCDS53504.1; -. [Q7Z4V0-3]
DR CCDS; CCDS7168.1; -. [Q7Z4V0-1]
DR RefSeq; NP_001137238.1; NM_001143766.1. [Q7Z4V0-1]
DR RefSeq; NP_001137239.1; NM_001143767.1. [Q7Z4V0-1]
DR RefSeq; NP_001137240.1; NM_001143768.1. [Q7Z4V0-1]
DR RefSeq; NP_001137241.1; NM_001143769.1. [Q7Z4V0-3]
DR RefSeq; NP_001137242.1; NM_001143770.1. [Q7Z4V0-2]
DR RefSeq; NP_001137243.1; NM_001143771.1. [Q7Z4V0-2]
DR RefSeq; NP_877432.1; NM_182755.2. [Q7Z4V0-1]
DR RefSeq; XP_006717456.1; XM_006717393.3.
DR RefSeq; XP_006717459.1; XM_006717396.3. [Q7Z4V0-1]
DR RefSeq; XP_006717461.1; XM_006717398.3. [Q7Z4V0-2]
DR RefSeq; XP_006717462.1; XM_006717399.3. [Q7Z4V0-2]
DR RefSeq; XP_011517673.1; XM_011519371.2. [Q7Z4V0-1]
DR RefSeq; XP_011517674.1; XM_011519372.2. [Q7Z4V0-1]
DR RefSeq; XP_011517675.1; XM_011519373.2. [Q7Z4V0-1]
DR RefSeq; XP_011517676.1; XM_011519374.2. [Q7Z4V0-1]
DR RefSeq; XP_011517678.1; XM_011519376.2. [Q7Z4V0-2]
DR RefSeq; XP_011517679.1; XM_011519377.2. [Q7Z4V0-2]
DR RefSeq; XP_016871353.1; XM_017015864.1. [Q7Z4V0-1]
DR RefSeq; XP_016871354.1; XM_017015865.1. [Q7Z4V0-1]
DR RefSeq; XP_016871355.1; XM_017015866.1. [Q7Z4V0-1]
DR RefSeq; XP_016871356.1; XM_017015867.1. [Q7Z4V0-1]
DR RefSeq; XP_016871357.1; XM_017015868.1. [Q7Z4V0-1]
DR RefSeq; XP_016871358.1; XM_017015869.1. [Q7Z4V0-1]
DR RefSeq; XP_016871359.1; XM_017015870.1. [Q7Z4V0-1]
DR RefSeq; XP_016871360.1; XM_017015871.1. [Q7Z4V0-1]
DR RefSeq; XP_016871361.1; XM_017015872.1. [Q7Z4V0-1]
DR RefSeq; XP_016871362.1; XM_017015873.1. [Q7Z4V0-2]
DR RefSeq; XP_016871363.1; XM_017015874.1. [Q7Z4V0-2]
DR AlphaFoldDB; Q7Z4V0; -.
DR BioGRID; 128661; 70.
DR IntAct; Q7Z4V0; 67.
DR MINT; Q7Z4V0; -.
DR STRING; 9606.ENSP00000412363; -.
DR iPTMnet; Q7Z4V0; -.
DR PhosphoSitePlus; Q7Z4V0; -.
DR BioMuta; ZNF438; -.
DR DMDM; 74759173; -.
DR EPD; Q7Z4V0; -.
DR MassIVE; Q7Z4V0; -.
DR MaxQB; Q7Z4V0; -.
DR PaxDb; Q7Z4V0; -.
DR PeptideAtlas; Q7Z4V0; -.
DR PRIDE; Q7Z4V0; -.
DR ProteomicsDB; 69244; -. [Q7Z4V0-1]
DR ProteomicsDB; 69245; -. [Q7Z4V0-2]
DR ProteomicsDB; 69246; -. [Q7Z4V0-3]
DR Antibodypedia; 50888; 13 antibodies from 8 providers.
DR DNASU; 220929; -.
DR Ensembl; ENST00000331737.10; ENSP00000333571.6; ENSG00000183621.15. [Q7Z4V0-2]
DR Ensembl; ENST00000361310.7; ENSP00000354663.3; ENSG00000183621.15. [Q7Z4V0-1]
DR Ensembl; ENST00000413025.5; ENSP00000387546.1; ENSG00000183621.15. [Q7Z4V0-1]
DR Ensembl; ENST00000436087.6; ENSP00000406934.2; ENSG00000183621.15. [Q7Z4V0-1]
DR Ensembl; ENST00000442986.5; ENSP00000412363.1; ENSG00000183621.15. [Q7Z4V0-1]
DR Ensembl; ENST00000452305.5; ENSP00000413060.1; ENSG00000183621.15. [Q7Z4V0-2]
DR Ensembl; ENST00000538351.6; ENSP00000445461.1; ENSG00000183621.15. [Q7Z4V0-3]
DR GeneID; 220929; -.
DR KEGG; hsa:220929; -.
DR MANE-Select; ENST00000436087.7; ENSP00000406934.2; NM_001143768.2; NP_001137240.1.
DR UCSC; uc001ivn.4; human. [Q7Z4V0-1]
DR CTD; 220929; -.
DR DisGeNET; 220929; -.
DR GeneCards; ZNF438; -.
DR HGNC; HGNC:21029; ZNF438.
DR HPA; ENSG00000183621; Low tissue specificity.
DR neXtProt; NX_Q7Z4V0; -.
DR OpenTargets; ENSG00000183621; -.
DR PharmGKB; PA143485677; -.
DR VEuPathDB; HostDB:ENSG00000183621; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00390000014526; -.
DR HOGENOM; CLU_017961_0_0_1; -.
DR InParanoid; Q7Z4V0; -.
DR OMA; PRNNKGS; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q7Z4V0; -.
DR TreeFam; TF332657; -.
DR PathwayCommons; Q7Z4V0; -.
DR SignaLink; Q7Z4V0; -.
DR BioGRID-ORCS; 220929; 7 hits in 1077 CRISPR screens.
DR ChiTaRS; ZNF438; human.
DR GenomeRNAi; 220929; -.
DR Pharos; Q7Z4V0; Tdark.
DR PRO; PR:Q7Z4V0; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q7Z4V0; protein.
DR Bgee; ENSG00000183621; Expressed in tibialis anterior and 160 other tissues.
DR ExpressionAtlas; Q7Z4V0; baseline and differential.
DR Genevisible; Q7Z4V0; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..828
FT /note="Zinc finger protein 438"
FT /id="PRO_0000245847"
FT ZN_FING 507..529
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 535..557
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 567..590
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 776..799
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..49
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019799"
FT VAR_SEQ 1..13
FT /note="MQNSVSVPPKDEG -> MDS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005, ECO:0000303|Ref.1"
FT /id="VSP_019800"
FT VARIANT 173
FT /note="P -> S (in dbSNP:rs10160116)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_027013"
FT VARIANT 381
FT /note="K -> N (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035580"
FT VARIANT 693
FT /note="L -> V (in dbSNP:rs35346752)"
FT /id="VAR_061946"
FT CONFLICT 668
FT /note="D -> G (in Ref. 3; BAD18510)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 828 AA; 91836 MW; 5C2F2253D932F578 CRC64;
MQNSVSVPPK DEGESNIPSG TIQSRKGLQN KSQFRTIAPK IVPKVLTSRM LPCHSPSRSD
QVNLGPSINS KLLGMSTQNY ALMQVAGQEG TFSLVALPHV ASAQPIQKPR MSLPENLKLP
IPRYQPPRNS KASRKKPILI FPKSGCSKAP AQTQMCPQMS PSPPHHPELL YKPSPFEEVP
SLEQAPASIS TAALTNGSDH GDLRPPVTNT HGSLNPPATP ASSTPEEPAK QDLTALSGKA
HFVSKITSSK PSAVASEKFK EQVDLAKTMT NLSPTILGNA VQLISSVPKG KLPIPPYSRM
KTMEVYKIKS DANIAGFSLP GPKADCDKIP STTEGFNAAT KVASRLPVPQ VSQQSACESA
FCPPTKLDLN HKTKLNSGAA KRKGRKRKVP DEILAFQGKR RKYIINKCRD GKERVKNDPQ
EFRDQKLGTL KKYRSIMPKP IMVIPTLASL ASPTTLQSQM LGGLGQDVLL NNSLTPKYLG
CKQDNSSSPK PSSVFRNGFS GIKKPWHRCH VCNHHFQFKQ HLRDHMNTHT NRRPYSCRIC
RKSYVRPGSL STHMKLHHGE NRLKKLMCCE FCAKVFGHIR VYFGHLKEVH RVVISTEPAP
SELQPGDIPK NRDMSVRGME GSLERENKSN LEEDFLLNQA DEVKLQIKCG RCQITAQSFA
EIKFHLLDVH GEEIEGRLQE GTFPGSKGTQ EELVQHASPD WKRHPERGKP EKVHSSSEES
HACPRLKRQL HLHQNGVEML MENEGPQSGT NKPRETCQGP ECPGLHTFLL WSHSGFNCLL
CAEMLGRKED LLHHWKHQHN CEDPSKLWAI LNTVSNQGVI ELSSEAEK
