ID   ZN438_PONAB             Reviewed;         827 AA.
AC   Q5RC05;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Zinc finger protein 438;
GN   Name=ZNF438;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR858477; CAH90705.1; -; mRNA.
DR   RefSeq; NP_001125390.1; NM_001131918.1.
DR   AlphaFoldDB; Q5RC05; -.
DR   PRIDE; Q5RC05; -.
DR   GeneID; 100172295; -.
DR   KEGG; pon:100172295; -.
DR   CTD; 220929; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q5RC05; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..827
FT                   /note="Zinc finger protein 438"
FT                   /id="PRO_0000245848"
FT   ZN_FING         506..528
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         534..556
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         566..589
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         775..798
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          193..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          682..723
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        692..723
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  91553 MW;  9D2BB31B63098DA1 CRC64;
     MQNSLSVPPR DEGESNIPSG TIQSRKGLQN KSQFRTIAPK IVPKVLTSRM LPCHSPSHSD
     QVNLGPSINS KPLGMSTQNY ALMQVAGQEG TFSLVALPHV ASAQPIQKPR MSLPENLKLP
     IPRYQPPRNS KGSRKKPILI FPKSGCSKAP AQTQMCPQMS PSPPHHPELL YKPSPFEEVP
     SLEQAPASIS TAALTNGSDH GDLRPPVTNT HGSLNPPATP ASPTPEEPAK QDLTDLSGKA
     HFVSKITSSK PSAVVSEKFK EQVYLAKTMT SLSPAILGNA VQLISSVPKG KLPIPPYSRM
     KTTEVYKIKS DANIAGFSLP GPKADCDKIS STTEGFNAAT KVASKLPVPQ VSQQSACESA
     FCPPTKLDLN HKTKLNSGAA KRKGRKWKVP DEILAFQGKR RKCIINKCRD GKERVKNDPQ
     EFRDQKLGTL KKYRSIMPKP IMVIPTLASL ASPTIQSQML GGLGQDVLLN NSLTPKYLGC
     KQDNSSSPKP SSVFRNGFSG IKKPWHRCHV CNHHFQFKQH LQDHMNTHTN RRPYSCRICR
     KSYVRPGSLS THMKLHHGEN RLKKLMCCEF CAKVFGHIRV YFGHLKEVHR VVISTEPAPS
     ELQPGDIPKN RDVSVQGMEG SLERENKSNL EEDFLLNQAG EVKLQIKCGR CQITAQSFAE
     IKFHLLYVHG EEIQGRLQEG TFPGSKGTQE ELVQHASHDW KRHPERGKPE KVHSSSEESH
     ACPRLKRQLH LHQNGVEMPI ENEGPQSGTN KPRETCQGPE CPGLHTVLLW SRSGFNCLLC
     AEMLGQKEDL LHHWKHQHNC EDPSKLWAIL NTVSNQGVIE LSSEAEK