ZN440_HUMAN
ID ZN440_HUMAN Reviewed; 595 AA.
AC Q8IYI8; Q8N1R9;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Zinc finger protein 440;
GN Name=ZNF440;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-569.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8IYI8; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-726439, EBI-3866279;
CC Q8IYI8; P49760: CLK2; NbExp=3; IntAct=EBI-726439, EBI-750020;
CC Q8IYI8; P68400: CSNK2A1; NbExp=3; IntAct=EBI-726439, EBI-347804;
CC Q8IYI8; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-726439, EBI-3867333;
CC Q8IYI8; Q5TD97: FHL5; NbExp=3; IntAct=EBI-726439, EBI-750641;
CC Q8IYI8; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-726439, EBI-11959885;
CC Q8IYI8; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-726439, EBI-11749135;
CC Q8IYI8; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-726439, EBI-10172150;
CC Q8IYI8; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-726439, EBI-12012928;
CC Q8IYI8; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-726439, EBI-10172290;
CC Q8IYI8; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-726439, EBI-10171774;
CC Q8IYI8; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-726439, EBI-10172052;
CC Q8IYI8; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-726439, EBI-11953334;
CC Q8IYI8; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-726439, EBI-14065470;
CC Q8IYI8; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-726439, EBI-11958132;
CC Q8IYI8; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-726439, EBI-11987425;
CC Q8IYI8; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-726439, EBI-3958099;
CC Q8IYI8; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-726439, EBI-1043191;
CC Q8IYI8; Q99750: MDFI; NbExp=10; IntAct=EBI-726439, EBI-724076;
CC Q8IYI8; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-726439, EBI-10172526;
CC Q8IYI8; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-726439, EBI-742948;
CC Q8IYI8; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-726439, EBI-11522433;
CC Q8IYI8; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-726439, EBI-945833;
CC Q8IYI8; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-726439, EBI-22310682;
CC Q8IYI8; Q16623: STX1A; NbExp=3; IntAct=EBI-726439, EBI-712466;
CC Q8IYI8; Q13077: TRAF1; NbExp=7; IntAct=EBI-726439, EBI-359224;
CC Q8IYI8; O76024: WFS1; NbExp=3; IntAct=EBI-726439, EBI-720609;
CC Q8IYI8; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-726439, EBI-373456;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC035760; AAH35760.1; -; mRNA.
DR EMBL; AK095252; BAC04510.1; -; mRNA.
DR CCDS; CCDS42503.1; -.
DR RefSeq; NP_689570.2; NM_152357.2.
DR AlphaFoldDB; Q8IYI8; -.
DR SMR; Q8IYI8; -.
DR BioGRID; 125953; 39.
DR IntAct; Q8IYI8; 32.
DR MINT; Q8IYI8; -.
DR STRING; 9606.ENSP00000305373; -.
DR iPTMnet; Q8IYI8; -.
DR PhosphoSitePlus; Q8IYI8; -.
DR BioMuta; ZNF440; -.
DR DMDM; 30580626; -.
DR jPOST; Q8IYI8; -.
DR MassIVE; Q8IYI8; -.
DR MaxQB; Q8IYI8; -.
DR PaxDb; Q8IYI8; -.
DR PeptideAtlas; Q8IYI8; -.
DR PRIDE; Q8IYI8; -.
DR ProteomicsDB; 71181; -.
DR Antibodypedia; 6949; 91 antibodies from 20 providers.
DR DNASU; 126070; -.
DR Ensembl; ENST00000304060.10; ENSP00000305373.5; ENSG00000171295.13.
DR GeneID; 126070; -.
DR KEGG; hsa:126070; -.
DR MANE-Select; ENST00000304060.10; ENSP00000305373.5; NM_152357.3; NP_689570.2.
DR UCSC; uc002msp.2; human.
DR CTD; 126070; -.
DR GeneCards; ZNF440; -.
DR HGNC; HGNC:20874; ZNF440.
DR HPA; ENSG00000171295; Low tissue specificity.
DR neXtProt; NX_Q8IYI8; -.
DR OpenTargets; ENSG00000171295; -.
DR PharmGKB; PA134917447; -.
DR VEuPathDB; HostDB:ENSG00000171295; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163273; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8IYI8; -.
DR OMA; RKNLYEC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8IYI8; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q8IYI8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8IYI8; -.
DR BioGRID-ORCS; 126070; 7 hits in 1096 CRISPR screens.
DR ChiTaRS; ZNF440; human.
DR GenomeRNAi; 126070; -.
DR Pharos; Q8IYI8; Tdark.
DR PRO; PR:Q8IYI8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IYI8; protein.
DR Bgee; ENSG00000171295; Expressed in buccal mucosa cell and 130 other tissues.
DR ExpressionAtlas; Q8IYI8; baseline and differential.
DR Genevisible; Q8IYI8; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..595
FT /note="Zinc finger protein 440"
FT /id="PRO_0000047589"
FT DOMAIN 4..86
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 144..166
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 172..194
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..250
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 256..278
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 284..306
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 312..334
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 340..362
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 368..390
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 396..418
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..448
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 458..480
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 43
FT /note="L -> I (in dbSNP:rs424132)"
FT /id="VAR_059915"
FT VARIANT 88
FT /note="P -> R (in dbSNP:rs448446)"
FT /id="VAR_052828"
FT VARIANT 124
FT /note="N -> S (in dbSNP:rs427880)"
FT /id="VAR_059916"
FT VARIANT 569
FT /note="S -> N (in dbSNP:rs400106)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_052829"
FT CONFLICT 40
FT /note="L -> M (in Ref. 1; BAC04510)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 595 AA; 69106 MW; 7DCCDFB698E40661 CRC64;
MDPVAFKDVA VNFTQEEWAL LDISQRKLYR EVMLETFRNL TSLGKRWKDQ NIEYEHQNPR
RNFRSLIEEK VNEIKDDSHC GETFTPVPDD RLNFQEKKAS PEVKSCESFV CGEVGLGNSS
FNMNIRGDIG HKAYEYQEYG PKPCKCQQPK KAFRYRPSFR TQERDHTGEK PNACKVCGKT
FISHSSVRRH MVMHSGDGPY KCKFCGKAFH CLRLYLIHER IHTGEKPCEC KQCGKSFSYS
ATHRIHKRTH TGEKPYEYQE CGKAFHSPRS YRRHERIHMG EKAYQCKECG KAFTCPRYVR
IHERTHSRKN LYECKQCGKA LSSLTSFQTH VRLHSGERPY ECKICGKDFC SVNSFQRHEK
IHSGEKPYKC KQCGKAFPHS SSLRYHERTH TGEKPYECKQ CGKAFRSASH LRVHGRTHTG
EKPYECKECG KAFRYVNNLQ SHERTQTHIR IHSGERRYKC KICGKGFYCP KSFQRHEKTH
TGEKLYECKQ RSVVPSVVPV PFDIMKGLTL ERSPINASNV GKPSELCQSF ECMVGLTLKR
NPMSVSNDGK PSDLPHTFEY VVGHTMERSP MHVRNVGNPS DLPRTFEFMK GHKHT
