ZN441_HUMAN
ID ZN441_HUMAN Reviewed; 693 AA.
AC Q8N8Z8;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Zinc finger protein 441;
GN Name=ZNF441;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-693 (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8N8Z8; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-17216366, EBI-3867333;
CC Q8N8Z8; Q92997: DVL3; NbExp=3; IntAct=EBI-17216366, EBI-739789;
CC Q8N8Z8; Q99750: MDFI; NbExp=3; IntAct=EBI-17216366, EBI-724076;
CC Q8N8Z8; P29122: PCSK6; NbExp=3; IntAct=EBI-17216366, EBI-2683528;
CC Q8N8Z8; O43609: SPRY1; NbExp=3; IntAct=EBI-17216366, EBI-3866665;
CC Q8N8Z8; Q16623: STX1A; NbExp=3; IntAct=EBI-17216366, EBI-712466;
CC Q8N8Z8; A0A1B0GUV7: TEX48; NbExp=3; IntAct=EBI-17216366, EBI-18583507;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N8Z8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N8Z8-2; Sequence=VSP_039877;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04661.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK095956; BAC04661.1; ALT_FRAME; mRNA.
DR EMBL; AC008543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC144217; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS12266.2; -. [Q8N8Z8-1]
DR RefSeq; NP_689568.2; NM_152355.2. [Q8N8Z8-1]
DR AlphaFoldDB; Q8N8Z8; -.
DR SMR; Q8N8Z8; -.
DR BioGRID; 125951; 8.
DR IntAct; Q8N8Z8; 8.
DR STRING; 9606.ENSP00000350576; -.
DR iPTMnet; Q8N8Z8; -.
DR PhosphoSitePlus; Q8N8Z8; -.
DR BioMuta; ZNF441; -.
DR DMDM; 308153532; -.
DR jPOST; Q8N8Z8; -.
DR MassIVE; Q8N8Z8; -.
DR MaxQB; Q8N8Z8; -.
DR PaxDb; Q8N8Z8; -.
DR PeptideAtlas; Q8N8Z8; -.
DR PRIDE; Q8N8Z8; -.
DR Antibodypedia; 13216; 113 antibodies from 22 providers.
DR DNASU; 126068; -.
DR Ensembl; ENST00000357901.5; ENSP00000350576.4; ENSG00000197044.11. [Q8N8Z8-1]
DR GeneID; 126068; -.
DR KEGG; hsa:126068; -.
DR MANE-Select; ENST00000357901.5; ENSP00000350576.4; NM_152355.3; NP_689568.2.
DR UCSC; uc010dyj.4; human. [Q8N8Z8-1]
DR CTD; 126068; -.
DR GeneCards; ZNF441; -.
DR HGNC; HGNC:20875; ZNF441.
DR HPA; ENSG00000197044; Low tissue specificity.
DR neXtProt; NX_Q8N8Z8; -.
DR OpenTargets; ENSG00000197044; -.
DR VEuPathDB; HostDB:ENSG00000197044; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000182755; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8N8Z8; -.
DR OMA; WESNACA; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N8Z8; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; Q8N8Z8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N8Z8; -.
DR BioGRID-ORCS; 126068; 13 hits in 1094 CRISPR screens.
DR GenomeRNAi; 126068; -.
DR Pharos; Q8N8Z8; Tdark.
DR PRO; PR:Q8N8Z8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N8Z8; protein.
DR Bgee; ENSG00000197044; Expressed in calcaneal tendon and 142 other tissues.
DR ExpressionAtlas; Q8N8Z8; baseline and differential.
DR Genevisible; Q8N8Z8; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..693
FT /note="Zinc finger protein 441"
FT /id="PRO_0000047590"
FT DOMAIN 4..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 169..190
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 196..218
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 224..246
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 252..274
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..302
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 308..330
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 336..358
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..413
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 419..441
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 447..469
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 475..497
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 503..525
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 531..553
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 559..581
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 587..609
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 615..637
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 643..665
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 671..693
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..44
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039877"
FT CONFLICT 122
FT /note="V -> I (in Ref. 1; BAC04661 and 3; BC144217)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="C -> Y (in Ref. 1; BAC04661)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="T -> A (in Ref. 1; BAC04661)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 693 AA; 80136 MW; BDB7F45CDFF7C217 CRC64;
MDSVAFEDVA INFTCEEWAL LGPSQKSLYR DVMQETIRNL DCIGMIWQNH DIEEDQYKDL
RRNLRCHMVE RACEIKDNSQ CGGPFTQTQD SIVNEKIPGV DPWESSECTD VLMGRSSLNC
YVRVDSEHKP CEYQEYGEKP YTHTQCGTAF SYQPCFQIHE RPQHGKKLYD CKECASFSSL
ENLQRHMAAH HGDGPRICKL CGNAFIWPSL FHMLRRTHTE EKPYEYEQCS TAFPAYSSTL
RHERTHSGEK PYQCKQCGKA FSCSCYTQLY ERTHTGEQSY ECKQCGKAFY HLGSFQRHMI
VHTGDGPHKC KICGKGFLSP SSVRRHKRTH TGEKPYECKY CGKAFSDCTG FRRHMITHTG
DGPHKCKVCG KAFDSPSLCR RHETTHTGEK PYKCECGKAF SDFYYFRNHE TTHTGEKPYK
CKQCGKAFIC CTYLQIHERI HTGERPYKCK QCGKAFRSSN YIRVHEKTHT GEKPYECKQC
GKALSHLKSF QRHMIMHTGD GPHKCKICGK SFDSPSSFRR HERIHTGERP YKCKLCGKGF
RSSSYIQLHE RTHTGEKPYG CQQCGKALSD LSSFRRHMIT HTGNGPHKCK ICGKGFDYPS
SVQRHERTHT GEKPYECKEC GKAFSHSSYL RIHERVHTGE KPYKCKECGK PFHCPSAFHK
HERTHSMEKP YKCKECGEAF HCISSFHKHE MTH
