ZN442_HUMAN
ID ZN442_HUMAN Reviewed; 627 AA.
AC Q9H7R0; B4DJ48;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Zinc finger protein 442;
GN Name=ZNF442;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP VARIANTS [LARGE SCALE ANALYSIS] SER-152 AND SER-243.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [4]
RP VARIANT LEU-590.
RX PubMed=21248752; DOI=10.1038/nature09639;
RA Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H.,
RA Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J.,
RA Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M.,
RA Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L.,
RA Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J.,
RA Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A.,
RA Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K.,
RA Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.;
RT "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene
RT PBRM1 in renal carcinoma.";
RL Nature 469:539-542(2011).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H7R0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H7R0-2; Sequence=VSP_055953;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK024418; BAB14916.1; -; mRNA.
DR EMBL; AK295923; BAG58710.1; -; mRNA.
DR EMBL; AC008758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS12271.1; -. [Q9H7R0-1]
DR CCDS; CCDS86707.1; -. [Q9H7R0-2]
DR RefSeq; NP_110451.1; NM_030824.2. [Q9H7R0-1]
DR RefSeq; XP_016882807.1; XM_017027318.1. [Q9H7R0-1]
DR AlphaFoldDB; Q9H7R0; -.
DR SMR; Q9H7R0; -.
DR BioGRID; 123040; 2.
DR IntAct; Q9H7R0; 1.
DR STRING; 9606.ENSP00000242804; -.
DR iPTMnet; Q9H7R0; -.
DR PhosphoSitePlus; Q9H7R0; -.
DR BioMuta; ZNF442; -.
DR DMDM; 30580638; -.
DR jPOST; Q9H7R0; -.
DR MassIVE; Q9H7R0; -.
DR MaxQB; Q9H7R0; -.
DR PaxDb; Q9H7R0; -.
DR PeptideAtlas; Q9H7R0; -.
DR PRIDE; Q9H7R0; -.
DR Antibodypedia; 26037; 32 antibodies from 14 providers.
DR DNASU; 79973; -.
DR Ensembl; ENST00000242804.9; ENSP00000242804.4; ENSG00000198342.10. [Q9H7R0-1]
DR Ensembl; ENST00000438182.5; ENSP00000388634.1; ENSG00000198342.10. [Q9H7R0-2]
DR Ensembl; ENST00000545749.2; ENSP00000440162.2; ENSG00000198342.10. [Q9H7R0-1]
DR GeneID; 79973; -.
DR KEGG; hsa:79973; -.
DR MANE-Select; ENST00000242804.9; ENSP00000242804.4; NM_030824.3; NP_110451.1.
DR UCSC; uc002mtr.2; human. [Q9H7R0-1]
DR CTD; 79973; -.
DR DisGeNET; 79973; -.
DR GeneCards; ZNF442; -.
DR HGNC; HGNC:20877; ZNF442.
DR HPA; ENSG00000198342; Tissue enhanced (brain).
DR neXtProt; NX_Q9H7R0; -.
DR OpenTargets; ENSG00000198342; -.
DR PharmGKB; PA134983440; -.
DR VEuPathDB; HostDB:ENSG00000198342; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000182755; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q9H7R0; -.
DR OMA; WEDTNTE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9H7R0; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q9H7R0; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9H7R0; -.
DR BioGRID-ORCS; 79973; 249 hits in 1058 CRISPR screens.
DR ChiTaRS; ZNF442; human.
DR GenomeRNAi; 79973; -.
DR Pharos; Q9H7R0; Tdark.
DR PRO; PR:Q9H7R0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9H7R0; protein.
DR Bgee; ENSG00000198342; Expressed in calcaneal tendon and 106 other tissues.
DR ExpressionAtlas; Q9H7R0; baseline and differential.
DR Genevisible; Q9H7R0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..627
FT /note="Zinc finger protein 442"
FT /id="PRO_0000047591"
FT DOMAIN 29..115
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 181..203
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 209..231
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 237..259
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 265..287
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 293..315
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 321..343
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..371
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 377..399
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 405..427
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 433..455
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 461..482
FT /note="C2H2-type 11; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 488..510
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 516..538
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 544..566
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 572..594
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 600..622
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055953"
FT VARIANT 93
FT /note="I -> V (in dbSNP:rs10423273)"
FT /id="VAR_052830"
FT VARIANT 110
FT /note="P -> T (in dbSNP:rs10415207)"
FT /id="VAR_024217"
FT VARIANT 152
FT /note="P -> S (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs10414971)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035581"
FT VARIANT 243
FT /note="C -> S (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs757755988)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035582"
FT VARIANT 422
FT /note="G -> R (in dbSNP:rs11085808)"
FT /id="VAR_052831"
FT VARIANT 443
FT /note="R -> C (in dbSNP:rs10500210)"
FT /id="VAR_024218"
FT VARIANT 590
FT /note="H -> L (found in a renal cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:21248752"
FT /id="VAR_064763"
SQ SEQUENCE 627 AA; 72863 MW; E95D75A75F807C68 CRC64;
MIVFGGEDRS DLFLPDSQTN EERKQYDSVA FEDVAVNFTQ EEWALLGPSQ KSLYRDVMWE
TIRNLDCIGM KWEDTNIEDQ HRNPRRSLRC HIIERFSESR QPDSTVNEKP PGVDPCKSSV
CGEIMGCSFL NCYITFDAGH KPDECQEYGE KPHTHKQCGT AFNYHHSFQT QERPHTGKKR
YDCKECGKTF SSSGNLRRHI IVQRGGGPYI CKLCGKAFFW PSLFRMHERT HTGEKPYECK
QCCKAFPIYS SYLRHERTHT GEKPYECKHC SKAFPDYSSY VRHERTHTGE KPYKCKRCGR
AFSVSSSLRI HERTHTGEKP YECKQCGKAF HHLGSFQRHM IRHTGDGPHK CKICGKGFDC
PSSLQSHERT HTGEKPYECK QCGKALSHHS SFRSHMIMHT GDGPHKCKVC GKAFIYPSVF
QGHERTHTGE KPYECKECGK AFRISSSLRR HETTHTGEKP YKCKCGKAFI DFYSFQNHET
THTGEKPYEC KECGKAFSCF TYLSQHRRTH MAEKPYECKT CKKAFSHFGN LKVHERIHTG
EKPYECKECR KAFSWLTCLL RHERIHTGKK SYECQQCGKA FTRSRFLRGH EKTHTGEKMH
ECKECGKALS SLSSLHRHKR THWRDTL
