ZN443_HUMAN
ID ZN443_HUMAN Reviewed; 671 AA.
AC Q9Y2A4;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Zinc finger protein 443;
DE AltName: Full=Krueppel-type zinc finger protein ZK1;
GN Name=ZNF443;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT PHE-485.
RX PubMed=9731181; DOI=10.1006/bbrc.1998.9201;
RA Katoh O., Oguri T., Takahashi T., Takai S., Fujiwara Y., Watanabe H.;
RT "ZK1, a novel Kruppel-type zinc finger gene, is induced following exposure
RT to ionizing radiation and enhances apoptotic cell death on hematopoietic
RT cells.";
RL Biochem. Biophys. Res. Commun. 249:595-600(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-485.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Induced following exposure to ionizing radiation.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB011414; BAA75543.1; -; mRNA.
DR EMBL; AC008758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032753; AAH32753.1; -; mRNA.
DR CCDS; CCDS32918.1; -.
DR PIR; JE0288; JE0288.
DR RefSeq; NP_005806.2; NM_005815.4.
DR AlphaFoldDB; Q9Y2A4; -.
DR SMR; Q9Y2A4; -.
DR BioGRID; 115518; 4.
DR IntAct; Q9Y2A4; 1.
DR STRING; 9606.ENSP00000301547; -.
DR iPTMnet; Q9Y2A4; -.
DR PhosphoSitePlus; Q9Y2A4; -.
DR BioMuta; ZNF443; -.
DR DMDM; 296453041; -.
DR EPD; Q9Y2A4; -.
DR jPOST; Q9Y2A4; -.
DR MassIVE; Q9Y2A4; -.
DR MaxQB; Q9Y2A4; -.
DR PaxDb; Q9Y2A4; -.
DR PeptideAtlas; Q9Y2A4; -.
DR PRIDE; Q9Y2A4; -.
DR ProteomicsDB; 85711; -.
DR Antibodypedia; 842; 80 antibodies from 19 providers.
DR DNASU; 10224; -.
DR Ensembl; ENST00000301547.10; ENSP00000301547.5; ENSG00000180855.16.
DR GeneID; 10224; -.
DR KEGG; hsa:10224; -.
DR MANE-Select; ENST00000301547.10; ENSP00000301547.5; NM_005815.5; NP_005806.3.
DR UCSC; uc002mtu.4; human.
DR CTD; 10224; -.
DR DisGeNET; 10224; -.
DR GeneCards; ZNF443; -.
DR HGNC; HGNC:20878; ZNF443.
DR HPA; ENSG00000180855; Low tissue specificity.
DR MIM; 606697; gene.
DR neXtProt; NX_Q9Y2A4; -.
DR OpenTargets; ENSG00000180855; -.
DR PharmGKB; PA134968382; -.
DR VEuPathDB; HostDB:ENSG00000180855; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000182755; -.
DR HOGENOM; CLU_002678_44_3_1; -.
DR InParanoid; Q9Y2A4; -.
DR OMA; PYKCKRG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9Y2A4; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; Q9Y2A4; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9Y2A4; -.
DR BioGRID-ORCS; 10224; 33 hits in 1056 CRISPR screens.
DR GenomeRNAi; 10224; -.
DR Pharos; Q9Y2A4; Tbio.
DR PRO; PR:Q9Y2A4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9Y2A4; protein.
DR Bgee; ENSG00000180855; Expressed in endometrium and 96 other tissues.
DR ExpressionAtlas; Q9Y2A4; baseline and differential.
DR Genevisible; Q9Y2A4; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..671
FT /note="Zinc finger protein 443"
FT /id="PRO_0000047592"
FT DOMAIN 4..86
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 134..159
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 169..191
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..498
FT /note="C2H2-type 13; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 504..526
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 532..554
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 560..582
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 588..610
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 616..638
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 649..671
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 111
FT /note="K -> I (in dbSNP:rs28599549)"
FT /id="VAR_061947"
FT VARIANT 111
FT /note="K -> N (in dbSNP:rs4239550)"
FT /id="VAR_059917"
FT VARIANT 397
FT /note="Q -> H (in dbSNP:rs35699767)"
FT /id="VAR_061948"
FT VARIANT 485
FT /note="C -> F (in dbSNP:rs10422063)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:9731181"
FT /id="VAR_059918"
FT VARIANT 591
FT /note="P -> Q (in dbSNP:rs7256321)"
FT /id="VAR_057420"
FT CONFLICT 72
FT /note="V -> I (in Ref. 1; BAA75543 and 3; AAH32753)"
FT /evidence="ECO:0000305"
FT CONFLICT 480
FT /note="K -> T (in Ref. 1; BAA75543 and 3; AAH32753)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 671 AA; 77516 MW; A715F816ADFD9A19 CRC64;
MASVALEDVA VNFTREEWAL LGPCQKNLYK DVMQETIRNL DCVVMKWKDQ NIEDQYRYPR
KNLRCRMLER FVESKDGTQC GETSSQIQDS IVTKNTLPGV GPCESSMRGE KVMGHSSLNC
YIRVGAGHKP HEYHECGEKP DTHKQRGKAF SYHNSFQTHE RLHTGKKPYD CKECGKSFSS
LGNLQRHMAV QRGDGPYKCK LCGKAFFWPS LLHMHERTHT GEKPYECKQC SKAFSFYSSY
LRHERTHTGE KPYECKQCSK AFPFYSSYLR HERTHTGEKP YKCKQCSKAF PDSSSCLIHE
RTHTGEKPYT CKQCGKAFSV SGSLQRHETT HSAEKPYACQ QCGKAFHHLG SFQRHMIRHT
GNGPHKCKIC GKGFDCPSSL QSHERTHTGE KPYECKQCGK ALSHRSSFRS HMIMHTGDGP
HKCKVCGKAF VYPSVFQRHE RTHTAEKPYK CKQCGKAYRI SSSLRRHETT HTGEKPYKCK
LGKACIDFCS FQNHKTTHTG EKPYECKECG KAFSRFRYLS RHKRTHTGEK PYECKTCRKA
FGHYDNLKVH ERIHSGEKPY ECKECGKAFS WLTCFLRHER IHMREKSYEC PQCGKAFTHS
RFLQGHEKTH TGENPYECKE CGKAFASLSS LHRHKKTHWK KTHTGENPYE CKECGKAFAS
LSSLHRHKKT H
