CC74A_HUMAN
ID CC74A_HUMAN Reviewed; 378 AA.
AC Q96AQ1; Q6P4I5;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Coiled-coil domain-containing protein 74A;
GN Name=CCDC74A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Eye, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96AQ1; Q96LK0: CEP19; NbExp=3; IntAct=EBI-8466689, EBI-741885;
CC Q96AQ1; Q8N720: ZNF655; NbExp=3; IntAct=EBI-8466689, EBI-625509;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96AQ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96AQ1-2; Sequence=VSP_022729;
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DR EMBL; AC093838; AAY14809.1; -; Genomic_DNA.
DR EMBL; BC016861; AAH16861.1; -; mRNA.
DR EMBL; BC063387; AAH63387.1; -; mRNA.
DR CCDS; CCDS2167.1; -. [Q96AQ1-1]
DR CCDS; CCDS58732.1; -. [Q96AQ1-2]
DR RefSeq; NP_001245235.1; NM_001258306.1. [Q96AQ1-2]
DR RefSeq; NP_620125.1; NM_138770.2. [Q96AQ1-1]
DR AlphaFoldDB; Q96AQ1; -.
DR SMR; Q96AQ1; -.
DR BioGRID; 124734; 37.
DR IntAct; Q96AQ1; 5.
DR MINT; Q96AQ1; -.
DR STRING; 9606.ENSP00000295171; -.
DR iPTMnet; Q96AQ1; -.
DR PhosphoSitePlus; Q96AQ1; -.
DR BioMuta; CCDC74A; -.
DR DMDM; 74731140; -.
DR MassIVE; Q96AQ1; -.
DR PaxDb; Q96AQ1; -.
DR PeptideAtlas; Q96AQ1; -.
DR PRIDE; Q96AQ1; -.
DR ProteomicsDB; 75984; -. [Q96AQ1-1]
DR ProteomicsDB; 75985; -. [Q96AQ1-2]
DR Antibodypedia; 33536; 21 antibodies from 11 providers.
DR DNASU; 90557; -.
DR Ensembl; ENST00000295171.10; ENSP00000295171.6; ENSG00000163040.15. [Q96AQ1-1]
DR Ensembl; ENST00000409856.8; ENSP00000387009.3; ENSG00000163040.15. [Q96AQ1-2]
DR GeneID; 90557; -.
DR KEGG; hsa:90557; -.
DR MANE-Select; ENST00000409856.8; ENSP00000387009.3; NM_001258306.3; NP_001245235.1. [Q96AQ1-2]
DR UCSC; uc002tta.5; human. [Q96AQ1-1]
DR CTD; 90557; -.
DR GeneCards; CCDC74A; -.
DR HGNC; HGNC:25197; CCDC74A.
DR HPA; ENSG00000163040; Tissue enhanced (testis).
DR neXtProt; NX_Q96AQ1; -.
DR OpenTargets; ENSG00000163040; -.
DR PharmGKB; PA143485425; -.
DR VEuPathDB; HostDB:ENSG00000163040; -.
DR eggNOG; ENOG502S5P9; Eukaryota.
DR GeneTree; ENSGT00390000007249; -.
DR HOGENOM; CLU_844571_0_0_1; -.
DR InParanoid; Q96AQ1; -.
DR OMA; MERSMEF; -.
DR OrthoDB; 553442at2759; -.
DR PhylomeDB; Q96AQ1; -.
DR TreeFam; TF329669; -.
DR PathwayCommons; Q96AQ1; -.
DR SignaLink; Q96AQ1; -.
DR BioGRID-ORCS; 90557; 17 hits in 995 CRISPR screens.
DR GenomeRNAi; 90557; -.
DR Pharos; Q96AQ1; Tdark.
DR PRO; PR:Q96AQ1; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96AQ1; protein.
DR Bgee; ENSG00000163040; Expressed in right uterine tube and 94 other tissues.
DR ExpressionAtlas; Q96AQ1; baseline and differential.
DR Genevisible; Q96AQ1; HS.
DR InterPro; IPR033226; CCDC74.
DR InterPro; IPR029422; CCDC74_C.
DR InterPro; IPR040370; CCDC74A/CCDC74B/CCDC92.
DR InterPro; IPR039496; CCDC92/74_CC_dom.
DR PANTHER; PTHR14882; PTHR14882; 1.
DR PANTHER; PTHR14882:SF7; PTHR14882:SF7; 1.
DR Pfam; PF14917; CCDC74_C; 1.
DR Pfam; PF14916; CCDC92; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..378
FT /note="Coiled-coil domain-containing protein 74A"
FT /id="PRO_0000274374"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 47..90
FT /evidence="ECO:0000255"
FT COMPBIAS 13..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 100..165
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022729"
FT VARIANT 302
FT /note="G -> R (in dbSNP:rs13660)"
FT /id="VAR_030268"
SQ SEQUENCE 378 AA; 41605 MW; 61D9EAAA5EDC34F9 CRC64;
MSGAGVAAGT RPPSSPTPGS RRRRQRPSVG VQSLRPQSPQ LRQSDPQKRN LDLEKSLQFL
QQQHSEMLAK LHEEIEHLKR ENKDLHYKLI MNQTSQKKDG PSGNHLSRAS APLGARWVCI
NGVWVEPGGP SPARLKEGSS RTHRPGGKRG RLAGGSADTV RSPADSLSMS SFQSVKSISN
SGKARPQPGS FNKQDSKADV SQKADLEEEP LLHNSKLDKV PGVQGQARKE KAEASNAGAA
CMGNSQHQGR QMGAGAHPPM ILPLPLRKPT TLRQCEVLIR ELWNTNLLQT QELRHLKSLL
EGSQRPQAAP EEASFPRDQE ATHFPKVSTK SLSKKCLSPP VAERAILPAL KQTPKNNFAE
RQKRLQAMQK RRLHRSVL
