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CC74B_HUMAN
ID   CC74B_HUMAN             Reviewed;         380 AA.
AC   Q96LY2; Q6NW18;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Coiled-coil domain-containing protein 74B;
GN   Name=CCDC74B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q96LY2-2; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-17967022, EBI-11096309;
CC       Q96LY2-2; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-17967022, EBI-11524452;
CC       Q96LY2-2; Q5T8I9: HENMT1; NbExp=3; IntAct=EBI-17967022, EBI-9675710;
CC       Q96LY2-2; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-17967022, EBI-11742507;
CC       Q96LY2-2; P40692: MLH1; NbExp=3; IntAct=EBI-17967022, EBI-744248;
CC       Q96LY2-2; P17252: PRKCA; NbExp=3; IntAct=EBI-17967022, EBI-1383528;
CC       Q96LY2-2; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-17967022, EBI-748391;
CC       Q96LY2-2; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-17967022, EBI-9090795;
CC       Q96LY2-2; Q8TF42: UBASH3B; NbExp=3; IntAct=EBI-17967022, EBI-1380492;
CC       Q96LY2-2; P61981: YWHAG; NbExp=3; IntAct=EBI-17967022, EBI-359832;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96LY2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96LY2-2; Sequence=VSP_022730;
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DR   EMBL; AK057609; BAB71533.1; -; mRNA.
DR   EMBL; BC067771; AAH67771.1; -; mRNA.
DR   CCDS; CCDS2155.1; -. [Q96LY2-1]
DR   CCDS; CCDS58726.1; -. [Q96LY2-2]
DR   RefSeq; NP_001245236.1; NM_001258307.1. [Q96LY2-2]
DR   RefSeq; NP_997193.1; NM_207310.2. [Q96LY2-1]
DR   AlphaFoldDB; Q96LY2; -.
DR   SMR; Q96LY2; -.
DR   BioGRID; 124829; 32.
DR   IntAct; Q96LY2; 33.
DR   MINT; Q96LY2; -.
DR   STRING; 9606.ENSP00000308873; -.
DR   iPTMnet; Q96LY2; -.
DR   PhosphoSitePlus; Q96LY2; -.
DR   BioMuta; CCDC74B; -.
DR   DMDM; 74732259; -.
DR   MassIVE; Q96LY2; -.
DR   PaxDb; Q96LY2; -.
DR   PeptideAtlas; Q96LY2; -.
DR   PRIDE; Q96LY2; -.
DR   Antibodypedia; 56078; 32 antibodies from 11 providers.
DR   DNASU; 91409; -.
DR   Ensembl; ENST00000310463.10; ENSP00000308873.6; ENSG00000152076.19. [Q96LY2-1]
DR   Ensembl; ENST00000409943.8; ENSP00000386294.3; ENSG00000152076.19. [Q96LY2-2]
DR   GeneID; 91409; -.
DR   KEGG; hsa:91409; -.
DR   MANE-Select; ENST00000409943.8; ENSP00000386294.3; NM_001258307.2; NP_001245236.1. [Q96LY2-2]
DR   UCSC; uc002tqm.3; human. [Q96LY2-1]
DR   CTD; 91409; -.
DR   GeneCards; CCDC74B; -.
DR   HGNC; HGNC:25267; CCDC74B.
DR   HPA; ENSG00000152076; Tissue enhanced (testis).
DR   neXtProt; NX_Q96LY2; -.
DR   OpenTargets; ENSG00000152076; -.
DR   PharmGKB; PA143485426; -.
DR   VEuPathDB; HostDB:ENSG00000152076; -.
DR   eggNOG; ENOG502S5P9; Eukaryota.
DR   GeneTree; ENSGT00390000007249; -.
DR   HOGENOM; CLU_844571_0_0_1; -.
DR   InParanoid; Q96LY2; -.
DR   OMA; HKNKRIP; -.
DR   PhylomeDB; Q96LY2; -.
DR   TreeFam; TF329669; -.
DR   PathwayCommons; Q96LY2; -.
DR   SignaLink; Q96LY2; -.
DR   BioGRID-ORCS; 91409; 31 hits in 999 CRISPR screens.
DR   ChiTaRS; CCDC74B; human.
DR   GenomeRNAi; 91409; -.
DR   Pharos; Q96LY2; Tdark.
DR   PRO; PR:Q96LY2; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q96LY2; protein.
DR   Bgee; ENSG00000152076; Expressed in right uterine tube and 96 other tissues.
DR   ExpressionAtlas; Q96LY2; baseline and differential.
DR   Genevisible; Q96LY2; HS.
DR   InterPro; IPR033226; CCDC74.
DR   InterPro; IPR029422; CCDC74_C.
DR   InterPro; IPR040370; CCDC74A/CCDC74B/CCDC92.
DR   InterPro; IPR039496; CCDC92/74_CC_dom.
DR   PANTHER; PTHR14882; PTHR14882; 1.
DR   PANTHER; PTHR14882:SF7; PTHR14882:SF7; 1.
DR   Pfam; PF14917; CCDC74_C; 1.
DR   Pfam; PF14916; CCDC92; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..380
FT                   /note="Coiled-coil domain-containing protein 74B"
FT                   /id="PRO_0000274375"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          47..93
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        13..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..103
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..197
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         100..165
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_022730"
FT   VARIANT         169
FT                   /note="T -> M (in dbSNP:rs184349150)"
FT                   /id="VAR_030269"
FT   VARIANT         346
FT                   /note="R -> H (in dbSNP:rs3177472)"
FT                   /id="VAR_030270"
SQ   SEQUENCE   380 AA;  41826 MW;  2B18E643CEB9E242 CRC64;
     MSGAGVAAGT RPPSSPTPGS RRRRQRPSVG VQSLRPQSPQ LRQSDPQKRN LDLEKSLQFL
     QQQHSEMLAK LHEEIEHLKR ENKDLRYKLI MNQTSQKKDG PSGNHLSRAS APLGARWVCI
     NGVWVEPGGP SPARLKEGSS RTHRPGGKHG RLAGGSADTV RSPADSLSTS SFQSVKSISN
     SGKARPQPGS FNKQDSKADV PQKADLEEEP LLHNSKLDKV PGVQGQARKE KAEASNAGAA
     CMGNSQHQGR QMGAAAHPPM ILPLPLRKPT TLRQCEVLIR ELWNTNLLQT QELQHLKSLL
     EGSQRPQAVP EEASFPRDQE ATHFPKVSTK SLSKKCLLLS PPVAERAILP ALKQTPKNNF
     AERQKRLQAM QKRRLHRSVL
 
 
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