ZN461_HUMAN
ID ZN461_HUMAN Reviewed; 563 AA.
AC Q8TAF7; A8K9W9; Q6VSF7; Q9ULZ8;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger protein 461;
DE AltName: Full=Gonadotropin-inducible ovary transcription repressor 1;
DE Short=GIOT-1;
GN Name=ZNF461; Synonyms=GIOT1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=15004467; DOI=10.1159/000076292;
RA Dai J., Li Y., Ji C., Jin F., Zheng Z., Wang X., Sun X., Xu X., Gu S.,
RA Xie Y., Mao Y.;
RT "Characterization of two novel KRAB-domain-containing zinc finger genes,
RT ZNF460 and ZNF461, on human chromosome 19q13.1-q13.4.";
RL Cytogenet. Genome Res. 103:74-78(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 244-563.
RC TISSUE=Ovary;
RA Okada T., Mizutani T., Miyamoto K.;
RT "Identification and characterization of novel zinc finger proteins in the
RT human ovary.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8TAF7; Q99750: MDFI; NbExp=3; IntAct=EBI-10271693, EBI-724076;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TAF7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TAF7-2; Sequence=VSP_011396;
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in liver,
CC kidney, pancreas, thymus, and small intestine.
CC {ECO:0000269|PubMed:15004467}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AY329493; AAR00226.1; -; mRNA.
DR EMBL; AK292834; BAF85523.1; -; mRNA.
DR EMBL; BC028631; AAH28631.1; -; mRNA.
DR EMBL; AB021641; BAA86987.1; -; mRNA.
DR CCDS; CCDS54257.1; -. [Q8TAF7-1]
DR RefSeq; NP_001284552.1; NM_001297623.2.
DR RefSeq; NP_694989.2; NM_153257.4. [Q8TAF7-1]
DR RefSeq; XP_011525788.1; XM_011527486.2. [Q8TAF7-2]
DR AlphaFoldDB; Q8TAF7; -.
DR SMR; Q8TAF7; -.
DR BioGRID; 124926; 8.
DR IntAct; Q8TAF7; 2.
DR STRING; 9606.ENSP00000467931; -.
DR iPTMnet; Q8TAF7; -.
DR PhosphoSitePlus; Q8TAF7; -.
DR BioMuta; ZNF461; -.
DR DMDM; 51338811; -.
DR EPD; Q8TAF7; -.
DR jPOST; Q8TAF7; -.
DR MassIVE; Q8TAF7; -.
DR MaxQB; Q8TAF7; -.
DR PaxDb; Q8TAF7; -.
DR PeptideAtlas; Q8TAF7; -.
DR PRIDE; Q8TAF7; -.
DR Antibodypedia; 8537; 109 antibodies from 19 providers.
DR DNASU; 92283; -.
DR Ensembl; ENST00000588268.6; ENSP00000467931.1; ENSG00000197808.13. [Q8TAF7-1]
DR GeneID; 92283; -.
DR KEGG; hsa:92283; -.
DR MANE-Select; ENST00000588268.6; ENSP00000467931.1; NM_153257.5; NP_694989.2.
DR UCSC; uc002oem.4; human. [Q8TAF7-1]
DR CTD; 92283; -.
DR GeneCards; ZNF461; -.
DR HGNC; HGNC:21629; ZNF461.
DR HPA; ENSG00000197808; Low tissue specificity.
DR MIM; 608640; gene.
DR neXtProt; NX_Q8TAF7; -.
DR OpenTargets; ENSG00000197808; -.
DR PharmGKB; PA145149895; -.
DR VEuPathDB; HostDB:ENSG00000197808; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163325; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8TAF7; -.
DR PhylomeDB; Q8TAF7; -.
DR PathwayCommons; Q8TAF7; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8TAF7; -.
DR BioGRID-ORCS; 92283; 9 hits in 1093 CRISPR screens.
DR ChiTaRS; ZNF461; human.
DR GenomeRNAi; 92283; -.
DR Pharos; Q8TAF7; Tdark.
DR PRO; PR:Q8TAF7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TAF7; protein.
DR Bgee; ENSG00000197808; Expressed in cortical plate and 95 other tissues.
DR ExpressionAtlas; Q8TAF7; baseline and differential.
DR Genevisible; Q8TAF7; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..563
FT /note="Zinc finger protein 461"
FT /id="PRO_0000047196"
FT DOMAIN 6..77
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 192..214
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..267
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 273..295
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 301..323
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 329..351
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 357..379
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 385..407
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 413..435
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 441..463
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 469..491
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 497..519
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 522..544
FT /note="C2H2-type 12; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..127
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_011396"
FT VARIANT 87
FT /note="N -> S (in dbSNP:rs10419469)"
FT /id="VAR_052834"
SQ SEQUENCE 563 AA; 66214 MW; 7530043A4940F028 CRC64;
MAHELVMFRD VAIDVSQEEW ECLNPAQRNL YKEVMLENYS NLVSLGLSVS KPAVISSLEQ
GKEPWMVVRE ETGRWCPGTW KTWGFHNNFL DNNEATDINA DLASRDEPQK LSPKRDIYET
ELSQWVNMEE FKSHSPERSI FSAIWEGNCH FEQHQGQEEG YFRQLMINHE NMPIFSQHTL
LTQEFYDREK ISECKKCRKI FSYHLFFSHH KRTHSKELSE CKECTEIVNT PCLFKQQTIQ
NGDKCNECKE CWKAFVHCSQ LKHLRIHNGE KRYECNECGK AFNYGSELTL HQRIHTGEKP
YECKECGKAF RQRSQLTQHQ RLHTGEKPYE CKQCGKAFIR GFQLTEHLRL HTGEKPYECK
ECGKTFRHRS HLTIHQRIHT GEKPYECREC GKAFSYHSSF SHHQKIHSGK KPYECHECGK
AFCDGLQLTL HQRIHTGEKP YECKECGKTF RQCSHLKRHQ RIHTGEKPHE CMICGKAFRL
HSHLIQHQRI HTGEKPYECK ECGKAFSYHS SFSHHQRIHS GKKPYQCGKA FNHRLQLNLH
QTLHTGEKPV RFPLLPPHPS LAS
