ZN469_HUMAN
ID ZN469_HUMAN Reviewed; 3925 AA.
AC Q96JG9;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Zinc finger protein 469;
GN Name=ZNF469; Synonyms=KIAA1858;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1457-3925, AND VARIANTS ARG-2358
RP AND GLN-2670 AND ARG-2848 AND GLN-3630 AND ALA-3636.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [3]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Kikuno R.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INVOLVEMENT IN BCS1, AND TISSUE SPECIFICITY.
RX PubMed=18452888; DOI=10.1016/j.ajhg.2008.04.001;
RA Abu A., Frydman M., Marek D., Pras E., Nir U., Reznik-Wolf H., Pras E.;
RT "Deleterious mutations in the Zinc-Finger 469 gene cause brittle cornea
RT syndrome.";
RL Am. J. Hum. Genet. 82:1217-1222(2008).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96JG9; P46937: YAP1; NbExp=2; IntAct=EBI-12503573, EBI-1044059;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in cornea, sclera, skin fibroblasts and
CC striated muscle. {ECO:0000269|PubMed:18452888}.
CC -!- DISEASE: Brittle cornea syndrome 1 (BCS1) [MIM:229200]: A disorder
CC characterized by extreme corneal thinning resulting in corneal rupture
CC after minor trauma, blue sclerae, keratoconus or keratoglobus,
CC hyperelasticity of the skin, and hypermobility of the joints. It shares
CC some features with, but is much less severe than, the ocular form of
CC Ehlers-Danlos syndrome (EDS6). {ECO:0000269|PubMed:18452888}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC135049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB058761; BAB47487.2; -; mRNA.
DR BioGRID; 124156; 7.
DR IntAct; Q96JG9; 8.
DR STRING; 9606.ENSP00000402343; -.
DR iPTMnet; Q96JG9; -.
DR PhosphoSitePlus; Q96JG9; -.
DR BioMuta; ZNF469; -.
DR DMDM; 158518658; -.
DR jPOST; Q96JG9; -.
DR MassIVE; Q96JG9; -.
DR MaxQB; Q96JG9; -.
DR PaxDb; Q96JG9; -.
DR PeptideAtlas; Q96JG9; -.
DR PRIDE; Q96JG9; -.
DR ProteomicsDB; 76962; -.
DR Antibodypedia; 77234; 4 antibodies from 4 providers.
DR Ensembl; ENST00000437464.1; ENSP00000402343.1; ENSG00000225614.4.
DR UCSC; uc002fku.2; human.
DR GeneCards; ZNF469; -.
DR HGNC; HGNC:23216; ZNF469.
DR HPA; ENSG00000225614; Tissue enhanced (brain).
DR MalaCards; ZNF469; -.
DR MIM; 229200; phenotype.
DR MIM; 612078; gene.
DR neXtProt; NX_Q96JG9; -.
DR Orphanet; 90354; Brittle cornea syndrome.
DR PharmGKB; PA134861470; -.
DR VEuPathDB; HostDB:ENSG00000225614; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_000186_0_0_1; -.
DR InParanoid; Q96JG9; -.
DR PhylomeDB; Q96JG9; -.
DR PathwayCommons; Q96JG9; -.
DR SignaLink; Q96JG9; -.
DR ChiTaRS; ZNF469; human.
DR Pharos; Q96JG9; Tbio.
DR PRO; PR:Q96JG9; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96JG9; protein.
DR Bgee; ENSG00000225614; Expressed in tibia and 165 other tissues.
DR ExpressionAtlas; Q96JG9; baseline and differential.
DR Genevisible; Q96JG9; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:ARUK-UCL.
DR GO; GO:1903053; P:regulation of extracellular matrix organization; IMP:ARUK-UCL.
DR InterPro; IPR039270; ZNF469.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR21465; PTHR21465; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..3925
FT /note="Zinc finger protein 469"
FT /id="PRO_0000047602"
FT ZN_FING 2444..2470
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 3087..3109
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 3309..3331
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 3337..3360
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 3390..3414
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1372..1433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1547..1582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1675..1836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1856..1919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1963..2002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2042..2887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2973..3008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3044..3082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3204..3294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3420..3473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3490..3897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..215
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..454
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..587
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..660
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..913
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1547..1565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1856..1872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..1998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2202..2218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2219..2236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2295..2311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2374..2411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2551..2603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2745..2761
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2777..2798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3230..3244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3601..3625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3643..3659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3700..3741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3846..3866
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 357
FT /note="S -> P (in dbSNP:rs11648572)"
FT /id="VAR_061949"
FT VARIANT 366
FT /note="R -> S (in dbSNP:rs11640794)"
FT /id="VAR_033285"
FT VARIANT 1162
FT /note="K -> E (in dbSNP:rs7197071)"
FT /id="VAR_033286"
FT VARIANT 1420
FT /note="P -> L (in dbSNP:rs4782300)"
FT /id="VAR_033287"
FT VARIANT 2129
FT /note="R -> K (in dbSNP:rs13334190)"
FT /id="VAR_033288"
FT VARIANT 2358
FT /note="G -> R (in dbSNP:rs12598474)"
FT /evidence="ECO:0000269|PubMed:11347906"
FT /id="VAR_033289"
FT VARIANT 2670
FT /note="L -> Q (in dbSNP:rs3812956)"
FT /evidence="ECO:0000269|PubMed:11347906"
FT /id="VAR_033290"
FT VARIANT 2710
FT /note="A -> T (in dbSNP:rs3812955)"
FT /id="VAR_033291"
FT VARIANT 2749
FT /note="D -> V (in dbSNP:rs3812954)"
FT /id="VAR_033292"
FT VARIANT 2848
FT /note="H -> R (in dbSNP:rs1983014)"
FT /evidence="ECO:0000269|PubMed:11347906"
FT /id="VAR_033293"
FT VARIANT 3630
FT /note="E -> Q (in dbSNP:rs1105066)"
FT /evidence="ECO:0000269|PubMed:11347906"
FT /id="VAR_033294"
FT VARIANT 3636
FT /note="T -> A (in dbSNP:rs904783)"
FT /evidence="ECO:0000269|PubMed:11347906"
FT /id="VAR_033295"
SQ SEQUENCE 3925 AA; 410202 MW; 7F4DDFA690574319 CRC64;
MPGERPRGAP PPTMTGDLQP RQVASSPGHP SQPPLEDNTP ATRTTKGARE AGGQAQAMEL
PEAQPRQARD GELKPPSLRG QAPSSTPGKR GSPQTPPGRS PLQAPSRLAG RAEGSPPQRY
ILGIASSRTK PTLDETPENP QLEAAQLPEV DTPQGPGTGA PLRPGLPRTE AQPAAEELGF
HRCFQEPPSS FTSTNYTSPS ATPRPPAPGP PQSRGTSPLQ PGSYPEYQAS GADSWPPAAE
NSFPGANFGV PPAEPEPIPK GSRPGGSPRG VSFQFPFPAL HGASTKPFPA DVAGHAFTNG
PLVFAFHQPQ GAWPEEAVGT GPAYPLPTQP APSPLPCYQG QPGGLNRHSD LSGALSSPGA
AHSAPRPFSD SLHKSLTKIL PERPPSAQDG LGSTRGPPSS LPQRHFPGQA YRASGVDTSP
GPPDTELAAP GPPPARLPQL WDPTAAPYPT PPGGPLAATR SMFFNGQPSP GQRLCLPQSA
PLPWPQVLPT ARPSPHGMEM LSRLPFPAGG PEWQGGSQGA LGTAGKTPGP REKLPAVRSS
QGGSPALFTY NGMTDPGAQP LFFGVAQPQV SPHGTPSLPP PRVVGASPSE SPLPSPATNT
AGSTCSSLSP MSSSPANPSS EESQLPGPLG PSAFFHPPTH PQETGSPFPS PEPPHSLPTH
YQPEPAKAFP FPADGLGAEG AFQCLEETPF PHEGPEVGRG GLQGFPRAPP PYPTHHFSLS
SASLDQLDVL LTCRQCDRNY SSLAAFLAHR QFCGLLLARA KDGHQRSPGP PGLPSPPAAP
RVPADAHAGL LSHAKTFLLA GDAQAEGKDD PLRTGFLPSL AATPFPLPAS DLDMEDDAKL
DSLITEALNG MEYQSDNPEI DSSFIDVFAD EEPSGPRGPS SGHPLKSKAG VTPESKAPPP
LPAATPDPQT PRPGDRGCPA RGRPKTRSLG LAPTEADAPS QGRQQRRGKQ LKLFRKDLDS
GGAAEGSGSG GGGRASGLRP RRNDGLGERP PPRPRRPRTQ APGSRADPAP RVPRAAALPE
ETRSSRRRRL PPRKDPRKRK ARGGAWGKEL ILKIVQQKNR LREYDFASES EEDEQPPPRG
PGFRGRRGRG EKRKEVELTQ GPREDEPQKP RKAARQEAGG DGAPANPEEP GGSRPGPGRS
PQARGPSRSL ETGAAAREGG PKCADRPSVA PKDPLQVPTN TETSEETRPS LDFPQEAKEP
ETAEESAPDS TEFTEALRSP PAACAGEMGA SPGLLIPEQP PPSRHDTGTP KPSGSLANTA
PHGSSPTPGV GSLLGGPGGT QAPVSHNSKD PPARQPGEFL APVANPSSTA CPKPSVLSSK
ISSFGCDPAG FNRDPLGVPV AKKGPQPYSS PHSELFLGPK DLAGCFLEEL HPKPSARDAP
PASSSCLCQD GEDAGSLEPQ LPRSPPGTAE TEPGRAASPP TLESSSLFPD LPVDRFDPPL
YGSLSANRDS GLPFACADPP QKTVPSDPPY PSFLLLEEVS PMLPSHFPDL SGGKVLSKTC
PPERTVVPGA APSLPGKGSG CSVALMSHLS EDELEIQKLV TELESQLQRS KDTRGAPREL
AEAESVGRVE LGTGTEPPSQ RRTCQATVPH EDTFSAADLT RVGESTAHRE GAESAVATVE
AVQGRPGGTW PCPASFHPGH AALLPCAQED LVSGAPFSPR GANFHFQPVQ KAGASKTGLC
QAEGDSRPPQ DVCLPEPSKQ PGPQLDAGSL AKCSPDQELS FPKNKEAASS QESEDSLRLL
PCEQRGGFLP EPGTADQPHR GAPAPEAFGS PAVHLAPDLA FQGDGAPPLD ATWPFGASPS
HAAQGHSAGR AGGHLHPTAG RPGFEGNEFA PAGASSLTAP RGREAWLVPV PSPACVSNTH
PSRRSQDPAL SPPIRQLQLP GPGVAKSKDG ILGLQELTPA AQSPPRVNPS GLEGGTVEGG
KVACGPAQGS PGGVQVTTLP AVAGHQLGLE ADGHWGLLGQ AEKTQGQGTA NQLQPENGVS
PGGTDNHASV NASPKTALTG PTEGAVLLEK CKGSRAAMSL QEEAEPTPSP PSPNRESLAL
ALTAAHSRSG SEGRTPERAS SPGLNKPLLA TGDSPAPSVG DLAACAPSPT SAAHMPCSLG
PLPREDPLTS PSRAQGGLGG QLPASPSCRD PPGPQQLLAC SPAWAPLEEA DGVQATTDTG
AEDSPVAPPS LTTSPCDPKE ALAGCLLQGE GSPLEDPSSW PPGSVSAVTC THSGDTPKDS
TLRIPEDSRK EKLWESPGRA TSPPLAGAVS PSVAVRATGL SSTPTGDEAQ AGRGLPGPDP
QSRGAPPHTN PDRMPRGHSS YSPSNTARLG HREGQAVTAV PTEPPTLQGA GPDSPACLEG
EMGTSSKEPE DPGTPETGRS GATKMPRVTC PSTGLGLGRT TAPSSTASDF QSDSPQSHRN
ASHQTPQGDP LGPQDLKQRS RGYKKKPAST ENGQWKGQAP HGPVTCEVCA ASFRSGPGLS
RHKARKHRPH PGAPAEPSPA ALPAQQPLEP LAQKCQPPRK KSHRVSGKER PNHSRGDPSH
VTQPPPAQGS KEVLRAPGSP HSQQLHPPSP TEHEVDVKTP ASKPRPDQAR EDELHPKQAE
KREGRRWRRE PTVDSPSHSE GKSNKKRGKL RGRRLREESI LPVSADVISD GRGSRPSPAM
ASYAASPSHC LSVEGGPEAD GEQPPRLATL GPGVMEGAAE TDQEALCAGE TGAQKPPGDR
MLCPGRMDGA ALGEQPTGQK GASARGFWGP RETKALGVCK ESGSEPAEDS SRAHSRSEEG
VWEENTPPLG PLGFPETSSS PADSTTSSCL QGLPDNPDTQ GGVQGPEGPT PDASGSSAKD
PPSLFDDEVS FSQLFPPGGR LTRKRNPHVY GKRCEKPVLP LPTQPSFEEG GDPTLGPARL
PTDLSDSSSL CLCHEDPWED EDPAGLPESF LLDGFLNSRV PGIDPWAPGL SLWALEPSRE
AGAEKLPSHC PEDDRPEAIP ELHMVPAAWR GLEMPAPADD SSSSLGDVSP EPPSLERERC
DGGLPGNTHL LPLRATDFEV LSTKFEMQDL CFLGPFEDPV GLPGPSFLDF EGTASSQGPQ
SRRTEEAAGA GRAQGRGRPA KGRRASYKCK VCFQRFRSLG ELDLHKLAHT PAPPPTCYMC
VERRFGSREL LRGHLQERHA QSKAGPWACG MCLKEVADVW MYNEHLREHA VRFARRGQAR
RSLGDLPGGL EGSSAVAHLL NSITEPAPKH HRGKRSAGKA AGSPGDPWGQ EGEAKKDSPG
ERAKPRARST PSNPDGAATP DSASATALAD AGSPGPPRTT PSPSPDPWAG GEPLLQATPV
HEACKDPSRD CHHCGKRFPK PFKLQRHLAV HSPQRVYLCP RCPRVYPEHG ELLAHLGGAH
GLLERPELQH TPLYACELCA TVMRIIKKSF ACSSCNYTFA KKEQFDRHMN KHLRGGRQPF
AFRGVRRPGA PGQKARALEG TLPSKRRRVA MPGSAPGPGE DRPPPRGSSP ILSEGSLPAL
LHLCSEVAPS TTKGWPETLE RPVDPVTHPI RGCELPSNHQ ECPPPSLSPF PAALADGRGD
CALDGALERP ENEASPGSPG PLLQQALPLG ASLPRPGARG QDAEGKRAPL VFSGKRRAPG
ARGRCAPDHF QEDHLLQKEK EVSSSHMVSE GGPRGTFHKG SATKPAGCQS SSKDRSAAST
PSKALKFPVH PRKAVGSLAP GELARGTENG MKPATPKAKP GPSSQGSGSP RPGTKTGGGS
QPQPASGQLQ SETATTPAKP SFPSRSPAPE RLPARAQAKS CTKGPREAGE QGPHGSLGPK
EKGESSTKRK KGQVPGPARS ESVGSFGRAP SAPDKPPRTP RKQATPSRVL PTKPKPNSQN
KPRPPPSEQR KAEPGHTQRK DRLGKAFPQG RPLLRPPKRG TAVHGAEPAE PHTHRTAEAQ
SDLLSQLFGQ RLTGFKIPLK KDASE
