ZN474_HUMAN
ID ZN474_HUMAN Reviewed; 364 AA.
AC Q6S9Z5; A8K4M0; Q96M07;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc finger protein 474;
DE AltName: Full=Testis-specific zinc finger protein;
DE Short=TSZFP;
GN Name=ZNF474;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Li L.-Y., Mo Y.-Q., Lu G.-X.;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6S9Z5; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-17269964, EBI-11096309;
CC Q6S9Z5; Q8N8Y2: ATP6V0D2; NbExp=3; IntAct=EBI-17269964, EBI-3923949;
CC Q6S9Z5; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-17269964, EBI-11524452;
CC Q6S9Z5; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-17269964, EBI-739879;
CC Q6S9Z5; Q9NP86: CABP5; NbExp=3; IntAct=EBI-17269964, EBI-10311131;
CC Q6S9Z5; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-17269964, EBI-10961624;
CC Q6S9Z5; Q9NX08: COMMD8; NbExp=3; IntAct=EBI-17269964, EBI-725694;
CC Q6S9Z5; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-17269964, EBI-12012272;
CC Q6S9Z5; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-17269964, EBI-11962928;
CC Q6S9Z5; Q9BZ67: FRMD8; NbExp=3; IntAct=EBI-17269964, EBI-5773072;
CC Q6S9Z5; Q8N954-2: GPATCH11; NbExp=3; IntAct=EBI-17269964, EBI-12178961;
CC Q6S9Z5; P62993: GRB2; NbExp=3; IntAct=EBI-17269964, EBI-401755;
CC Q6S9Z5; P13807: GYS1; NbExp=3; IntAct=EBI-17269964, EBI-740553;
CC Q6S9Z5; Q14005-2: IL16; NbExp=3; IntAct=EBI-17269964, EBI-17178971;
CC Q6S9Z5; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-17269964, EBI-11954971;
CC Q6S9Z5; Q9BTE3-2: MCMBP; NbExp=3; IntAct=EBI-17269964, EBI-9384556;
CC Q6S9Z5; P40692: MLH1; NbExp=3; IntAct=EBI-17269964, EBI-744248;
CC Q6S9Z5; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-17269964, EBI-12025760;
CC Q6S9Z5; P16118: PFKFB1; NbExp=3; IntAct=EBI-17269964, EBI-709807;
CC Q6S9Z5; O60437: PPL; NbExp=3; IntAct=EBI-17269964, EBI-368321;
CC Q6S9Z5; O43741: PRKAB2; NbExp=3; IntAct=EBI-17269964, EBI-1053424;
CC Q6S9Z5; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-17269964, EBI-748350;
CC Q6S9Z5; P49903: SEPHS1; NbExp=3; IntAct=EBI-17269964, EBI-714091;
CC Q6S9Z5; Q9Y242: TCF19; NbExp=3; IntAct=EBI-17269964, EBI-7413767;
CC Q6S9Z5; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-17269964, EBI-750487;
CC Q6S9Z5; P36406: TRIM23; NbExp=3; IntAct=EBI-17269964, EBI-740098;
CC Q6S9Z5; Q969E8: TSR2; NbExp=3; IntAct=EBI-17269964, EBI-746981;
CC Q6S9Z5; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-17269964, EBI-7353612;
CC Q6S9Z5; Q15915: ZIC1; NbExp=3; IntAct=EBI-17269964, EBI-11963196;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71507.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY461732; AAS21253.1; -; mRNA.
DR EMBL; AK057483; BAB71507.1; ALT_FRAME; mRNA.
DR EMBL; AK290985; BAF83674.1; -; mRNA.
DR EMBL; CH471086; EAW48893.1; -; Genomic_DNA.
DR EMBL; BC133022; AAI33023.1; -; mRNA.
DR EMBL; BC133026; AAI33027.1; -; mRNA.
DR CCDS; CCDS4130.1; -.
DR RefSeq; NP_997200.1; NM_207317.2.
DR AlphaFoldDB; Q6S9Z5; -.
DR BioGRID; 126377; 29.
DR IntAct; Q6S9Z5; 29.
DR STRING; 9606.ENSP00000296600; -.
DR iPTMnet; Q6S9Z5; -.
DR PhosphoSitePlus; Q6S9Z5; -.
DR BioMuta; ZNF474; -.
DR DMDM; 74758522; -.
DR EPD; Q6S9Z5; -.
DR MassIVE; Q6S9Z5; -.
DR PaxDb; Q6S9Z5; -.
DR PeptideAtlas; Q6S9Z5; -.
DR PRIDE; Q6S9Z5; -.
DR ProteomicsDB; 67352; -.
DR Antibodypedia; 25613; 43 antibodies from 12 providers.
DR DNASU; 133923; -.
DR Ensembl; ENST00000296600.5; ENSP00000296600.4; ENSG00000164185.6.
DR GeneID; 133923; -.
DR KEGG; hsa:133923; -.
DR MANE-Select; ENST00000296600.5; ENSP00000296600.4; NM_207317.3; NP_997200.1.
DR UCSC; uc003ksv.4; human.
DR CTD; 133923; -.
DR GeneCards; ZNF474; -.
DR HGNC; HGNC:23245; ZNF474.
DR HPA; ENSG00000164185; Tissue enhanced (choroid plexus, fallopian tube, testis).
DR neXtProt; NX_Q6S9Z5; -.
DR OpenTargets; ENSG00000164185; -.
DR PharmGKB; PA144596519; -.
DR VEuPathDB; HostDB:ENSG00000164185; -.
DR eggNOG; ENOG502QWEF; Eukaryota.
DR GeneTree; ENSGT00940000164652; -.
DR HOGENOM; CLU_882643_0_0_1; -.
DR InParanoid; Q6S9Z5; -.
DR OMA; KVIHATQ; -.
DR OrthoDB; 778172at2759; -.
DR PhylomeDB; Q6S9Z5; -.
DR TreeFam; TF328720; -.
DR PathwayCommons; Q6S9Z5; -.
DR SignaLink; Q6S9Z5; -.
DR BioGRID-ORCS; 133923; 10 hits in 1067 CRISPR screens.
DR ChiTaRS; ZNF474; human.
DR GenomeRNAi; 133923; -.
DR Pharos; Q6S9Z5; Tdark.
DR PRO; PR:Q6S9Z5; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6S9Z5; protein.
DR Bgee; ENSG00000164185; Expressed in bronchial epithelial cell and 95 other tissues.
DR ExpressionAtlas; Q6S9Z5; baseline and differential.
DR Genevisible; Q6S9Z5; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR026319; ZC2HC1.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR13555; PTHR13555; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..364
FT /note="Zinc finger protein 474"
FT /id="PRO_0000280414"
FT ZN_FING 166..189
FT /note="C2H2-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 173
FT /note="R -> H (in dbSNP:rs2560306)"
FT /id="VAR_031146"
SQ SEQUENCE 364 AA; 40315 MW; 3A9467A1C118DE7C CRC64;
MERGKKKRIS NKLQQTFHHS KEPTFLINQA GLLSSDSYSS LSPETESVNP GENIKTDTQK
KRPGTVILSK LSSRRIISES QLSPPVIPAR RPGFRVCYIC GREFGSQSIA IHEPQCLQKW
HIENSKLPKH LRRPEPSKPQ SLSSSGSYSL QATNEAAFQS AQAQLLPCES CGRTFLPDHL
LVHHRSCKPK GEGPRAPHSN SSDHLTGLKK ACSGTPARPR TVICYICGKE FGTLSLPIHE
PKCLEKWKME NDRLPVELHQ PLPQKPQPLP NAQSSQAGPN QAQLVFCPHC SRIFTSDRLL
VHQRSCKTHP YGPKYQNLNL GSKGGLKEYT NSKQQRNRAA PSVTDKVIHA TQDALGEPGG
ALCL
