ZN474_MOUSE
ID ZN474_MOUSE Reviewed; 347 AA.
AC Q6V5K9; Q9D472; Q9D985;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Zinc finger protein 474;
DE AltName: Full=Testis-specific zinc finger protein;
DE Short=TSZFP;
GN Name=Znf474; Synonyms=Zfp474;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Zhou C., Li L.-Y., Mo Y.-Q., Lu G.-X.;
RT "Identification of a novel mouse protein with two C2H2 zinc finger
RT domains.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AY350709; AAQ88275.1; -; mRNA.
DR EMBL; AK007266; BAB24926.2; -; mRNA.
DR EMBL; AK016749; BAB30408.1; -; mRNA.
DR EMBL; AC161119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466528; EDL09922.1; -; Genomic_DNA.
DR EMBL; BC055099; AAH55099.1; -; mRNA.
DR CCDS; CCDS29248.1; -.
DR RefSeq; NP_080025.3; NM_025749.3.
DR RefSeq; XP_006526221.1; XM_006526158.2.
DR RefSeq; XP_006526222.1; XM_006526159.2.
DR RefSeq; XP_006526223.1; XM_006526160.2.
DR RefSeq; XP_006526224.1; XM_006526161.2.
DR RefSeq; XP_006526225.1; XM_006526162.2.
DR RefSeq; XP_006526228.1; XM_006526165.2.
DR RefSeq; XP_011245285.1; XM_011246983.2.
DR RefSeq; XP_011245286.1; XM_011246984.2.
DR AlphaFoldDB; Q6V5K9; -.
DR STRING; 10090.ENSMUSP00000072453; -.
DR PhosphoSitePlus; Q6V5K9; -.
DR PaxDb; Q6V5K9; -.
DR PRIDE; Q6V5K9; -.
DR ProteomicsDB; 275290; -.
DR Antibodypedia; 25613; 43 antibodies from 12 providers.
DR DNASU; 66758; -.
DR Ensembl; ENSMUST00000072666; ENSMUSP00000072453; ENSMUSG00000046886.
DR Ensembl; ENSMUST00000209270; ENSMUSP00000147873; ENSMUSG00000046886.
DR GeneID; 66758; -.
DR KEGG; mmu:66758; -.
DR UCSC; uc008exh.2; mouse.
DR CTD; 66758; -.
DR MGI; MGI:1914008; Zfp474.
DR VEuPathDB; HostDB:ENSMUSG00000046886; -.
DR eggNOG; ENOG502QWEF; Eukaryota.
DR GeneTree; ENSGT00940000164652; -.
DR HOGENOM; CLU_882643_0_0_1; -.
DR InParanoid; Q6V5K9; -.
DR OMA; KVIHATQ; -.
DR OrthoDB; 778172at2759; -.
DR PhylomeDB; Q6V5K9; -.
DR TreeFam; TF328720; -.
DR BioGRID-ORCS; 66758; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp474; mouse.
DR PRO; PR:Q6V5K9; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q6V5K9; protein.
DR Bgee; ENSMUSG00000046886; Expressed in seminiferous tubule of testis and 26 other tissues.
DR Genevisible; Q6V5K9; MM.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR026319; ZC2HC1.
DR PANTHER; PTHR13555; PTHR13555; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..347
FT /note="Zinc finger protein 474"
FT /id="PRO_0000353099"
FT ZN_FING 163..186
FT /note="C2H2-type; degenerate"
FT REGION 124..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 145
FT /note="H -> Y (in Ref. 1; AAQ88275)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 347 AA; 38134 MW; 1A08ABFE7AC36A82 CRC64;
MESGNERISS QSQGTIHLSK EPTFLIQQAT LPSDLHSTLL QETQCGGLTK NIKANTQKRR
PGTVILSKRS SRIMSETQPR PPVIPSRRPG FRICYICGRE FGSQSLAIHE PQCLEKWRTE
NSKLPKHLRR PEPSKPQPIG GTDSHSLQAA NEEAFQSAQA QLLPCENCGR TFLPDRLLVH
QRSCKPKGEN PGPPSMGSSN VPTGLKKASS GIPARPRTLI CYICGREFGT LSLPIHEPKC
LEKWKIENDQ LPRELRRPQP QKPQPLPAGQ SSQEGASQAA LVPCPNCGRT FAVDRLPVHQ
RSCKSQPSGP KTSNSNIERK GGPNPPTNSK QQRNMEAPNG DKVTGVI
