ZN479_HUMAN
ID ZN479_HUMAN Reviewed; 524 AA.
AC Q96JC4;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger protein 479;
DE AltName: Full=Zinc finger protein Kr19;
DE Short=HKr19;
GN Name=ZNF479;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=11410164; DOI=10.1089/104454901750232472;
RA Mark C., Looman C., Abrink M., Hellman L.;
RT "Molecular cloning and preliminary functional analysis of two novel human
RT KRAB zinc finger proteins, HKr18 and HKr19.";
RL DNA Cell Biol. 20:275-286(2001).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96JC4; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10820574, EBI-5916454;
CC Q96JC4; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10820574, EBI-12012928;
CC Q96JC4; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-10820574, EBI-11987425;
CC Q96JC4; Q99750: MDFI; NbExp=3; IntAct=EBI-10820574, EBI-724076;
CC Q96JC4; Q16623: STX1A; NbExp=3; IntAct=EBI-10820574, EBI-712466;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed primarily in testis and fetal tissues.
CC {ECO:0000269|PubMed:11410164}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF277624; AAK61307.1; -; mRNA.
DR CCDS; CCDS43590.1; -.
DR RefSeq; NP_150376.1; NM_033273.2.
DR RefSeq; XP_011513906.1; XM_011515604.2.
DR RefSeq; XP_011513910.1; XM_011515608.2.
DR RefSeq; XP_016868266.1; XM_017012777.1.
DR AlphaFoldDB; Q96JC4; -.
DR SMR; Q96JC4; -.
DR BioGRID; 124767; 7.
DR IntAct; Q96JC4; 7.
DR STRING; 9606.ENSP00000333776; -.
DR iPTMnet; Q96JC4; -.
DR PhosphoSitePlus; Q96JC4; -.
DR BioMuta; ZNF479; -.
DR DMDM; 38258829; -.
DR jPOST; Q96JC4; -.
DR MassIVE; Q96JC4; -.
DR MaxQB; Q96JC4; -.
DR PaxDb; Q96JC4; -.
DR PeptideAtlas; Q96JC4; -.
DR PRIDE; Q96JC4; -.
DR ProteomicsDB; 76941; -.
DR Antibodypedia; 67579; 52 antibodies from 10 providers.
DR DNASU; 90827; -.
DR Ensembl; ENST00000319636.10; ENSP00000324518.6; ENSG00000185177.14.
DR Ensembl; ENST00000331162.8; ENSP00000333776.4; ENSG00000185177.14.
DR GeneID; 90827; -.
DR KEGG; hsa:90827; -.
DR MANE-Select; ENST00000319636.10; ENSP00000324518.6; NM_001370129.2; NP_001357058.1.
DR UCSC; uc010kzo.4; human.
DR CTD; 90827; -.
DR DisGeNET; 90827; -.
DR GeneCards; ZNF479; -.
DR HGNC; HGNC:23258; ZNF479.
DR HPA; ENSG00000185177; Tissue enriched (testis).
DR MIM; 617444; gene.
DR neXtProt; NX_Q96JC4; -.
DR PharmGKB; PA134903704; -.
DR VEuPathDB; HostDB:ENSG00000185177; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244908; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q96JC4; -.
DR OMA; MESELCG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96JC4; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q96JC4; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96JC4; -.
DR BioGRID-ORCS; 90827; 33 hits in 1016 CRISPR screens.
DR ChiTaRS; ZNF479; human.
DR GenomeRNAi; 90827; -.
DR Pharos; Q96JC4; Tbio.
DR PRO; PR:Q96JC4; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96JC4; protein.
DR Bgee; ENSG00000185177; Expressed in buccal mucosa cell and 4 other tissues.
DR Genevisible; Q96JC4; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..524
FT /note="Zinc finger protein 479"
FT /id="PRO_0000047606"
FT DOMAIN 16..87
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 185..212
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 213..235
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 241..263
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 269..291
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 297..319
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 325..347
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..403
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 409..431
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 437..459
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 524 AA; 60598 MW; F1AD4929DC67D105 CRC64;
MAKRPGPPGS REMGLLTFRD IAIEFSLEEW QCLDCAQRNL YRDVMLENYR NLVSLGIAVS
KPDLITCLEQ NKESQNIKRN EMVAKHPVTR SHFTQDLQPE QGIKDSLQKV IPRTYGKCGH
EKLQFKKCCK SVGEYEVHKG GYSEVNQCLS TTQNKIFQTH KYVKVFGKFS NSNRDKTRYT
GNKHFKCNKY GKSFCMLSHL NQHQVIHTRE KSYKCKECGK SFNCSSNHTT HKIIHTGEKP
YRCEECGKAF SWSANLTRHK RTHTGEKPYT CEECGQAFRR SSALTNHKRI HTGERPYKCE
ECGKAFSVSS TLTDHKRIHT GEKPCRCEEC GKAFSWSSNL TRHKRIHTRE KPYACEECGQ
AFSLSSNLMR HRRIHTGEKP YTCEECGQDF RRSSALTIHK RIHTGERPYK CEECGKVFSL
SSTLTDHKRI HTGERPYKCE ECGKAFSLSS TLTDHKRIHT GERPYTCEEC GKAFNCSSTL
MQHKRIHTGE KPYKCEECEQ AFKWHSSLAK HKIIHTGEKP YKCE
