CC85A_MOUSE
ID CC85A_MOUSE Reviewed; 500 AA.
AC Q5SP85; Q69Z68; Q6NZL9; Q8BGZ5; Q8BLC5; Q8VCC5;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Coiled-coil domain-containing protein 85A;
GN Name=Ccdc85a; Synonyms=Kiaa1912;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 86-500 (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-488, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: May play a role in cell-cell adhesion and epithelium
CC development through its interaction with proteins of the beta-catenin
CC family. {ECO:0000250|UniProtKB:Q96PX6}.
CC -!- SUBUNIT: May interact with ARVCF; CTNND1; CTNND2 AND PKP4.
CC {ECO:0000250|UniProtKB:Q96PX6}.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000250|UniProtKB:Q96PX6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5SP85-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SP85-2; Sequence=VSP_022283;
CC Name=3;
CC IsoId=Q5SP85-3; Sequence=VSP_022280, VSP_022283;
CC -!- SIMILARITY: Belongs to the CCDC85 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC39790.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.; Evidence={ECO:0000305};
CC Sequence=BAC39795.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.; Evidence={ECO:0000305};
CC Sequence=BAD32576.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK173298; BAD32576.1; ALT_INIT; mRNA.
DR EMBL; AK045568; BAC32419.1; -; mRNA.
DR EMBL; AK087049; BAC39790.1; ALT_SEQ; mRNA.
DR EMBL; AK087070; BAC39795.1; ALT_SEQ; mRNA.
DR EMBL; AL929280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX255910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC020949; AAH20949.1; -; mRNA.
DR EMBL; BC066065; AAH66065.1; -; mRNA.
DR CCDS; CCDS24489.1; -. [Q5SP85-1]
DR CCDS; CCDS48760.1; -. [Q5SP85-2]
DR RefSeq; NP_001160133.1; NM_001166661.2. [Q5SP85-2]
DR RefSeq; NP_853555.2; NM_181577.5. [Q5SP85-1]
DR AlphaFoldDB; Q5SP85; -.
DR SMR; Q5SP85; -.
DR BioGRID; 229765; 1.
DR STRING; 10090.ENSMUSP00000090941; -.
DR iPTMnet; Q5SP85; -.
DR PhosphoSitePlus; Q5SP85; -.
DR MaxQB; Q5SP85; -.
DR PaxDb; Q5SP85; -.
DR PRIDE; Q5SP85; -.
DR ProteomicsDB; 265354; -. [Q5SP85-1]
DR ProteomicsDB; 265355; -. [Q5SP85-2]
DR ProteomicsDB; 265356; -. [Q5SP85-3]
DR Antibodypedia; 50392; 32 antibodies from 12 providers.
DR DNASU; 216613; -.
DR Ensembl; ENSMUST00000042534; ENSMUSP00000044649; ENSMUSG00000032878. [Q5SP85-2]
DR Ensembl; ENSMUST00000093253; ENSMUSP00000090941; ENSMUSG00000032878. [Q5SP85-1]
DR Ensembl; ENSMUST00000109502; ENSMUSP00000105128; ENSMUSG00000032878. [Q5SP85-3]
DR GeneID; 216613; -.
DR KEGG; mmu:216613; -.
DR UCSC; uc007igk.3; mouse. [Q5SP85-1]
DR UCSC; uc007igl.3; mouse. [Q5SP85-2]
DR CTD; 114800; -.
DR MGI; MGI:2445069; Ccdc85a.
DR VEuPathDB; HostDB:ENSMUSG00000032878; -.
DR eggNOG; KOG3819; Eukaryota.
DR GeneTree; ENSGT00940000157361; -.
DR HOGENOM; CLU_028762_1_1_1; -.
DR InParanoid; Q5SP85; -.
DR OMA; EHHEKSC; -.
DR OrthoDB; 1393196at2759; -.
DR PhylomeDB; Q5SP85; -.
DR TreeFam; TF320243; -.
DR BioGRID-ORCS; 216613; 6 hits in 73 CRISPR screens.
DR ChiTaRS; Ccdc85a; mouse.
DR PRO; PR:Q5SP85; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5SP85; protein.
DR Bgee; ENSMUSG00000032878; Expressed in dentate gyrus of hippocampal formation and 167 other tissues.
DR ExpressionAtlas; Q5SP85; baseline and differential.
DR Genevisible; Q5SP85; MM.
DR GO; GO:0005912; C:adherens junction; ISO:MGI.
DR InterPro; IPR019359; CCDC85.
DR PANTHER; PTHR13546; PTHR13546; 1.
DR Pfam; PF10226; CCDC85; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell junction; Coiled coil; Methylation;
KW Reference proteome.
FT CHAIN 1..500
FT /note="Coiled-coil domain-containing protein 85A"
FT /id="PRO_0000271105"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 38..104
FT /evidence="ECO:0000255"
FT COILED 132..171
FT /evidence="ECO:0000255"
FT COILED 404..429
FT /evidence="ECO:0000255"
FT COMPBIAS 215..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 488
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 179..206
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022280"
FT VAR_SEQ 432..471
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15368895,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_022283"
FT CONFLICT 161
FT /note="K -> E (in Ref. 2; BAC32419)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 500 AA; 54483 MW; 550E0F41FAD59DEC CRC64;
MSKAAGGSAP AAESCPSAPA GASTPTGVDD LSKVTDEELL QWSKEELIRS LRRAEAEKVS
AMLDHSNLIR EVNRRLQLHL GEIRGLKDIN QKLQEDNQEL RDLCCFLDDD RQKGKRVSRE
WQRLGRYTAG VMHKEVALYL QKLKELEVKQ EEVVKENMEL KELCMLLDEE KGVGCAGSRC
SIDSQASLCQ LVASATPYVR DVGDGSSTSS TGSTDSPDHH KHHASGGSPE HLQKPRSEGS
PEHTKHRSTS PEHLHKPRAS GTPDHSKALK GPSPEHHKPL CKGSPEQQRH PHPGSSPEVL
PKHVLSGSPE HFQKHRPGGS PEHTRHSGGS PEHLQKHALG GSLEHLPRAR GTSPEHLKQH
YGASPDHKHA SGSGGSGGGS REGTLRRPAQ EDSSSHHRNV YSGMNESTLS YVRQLEARVR
QLEEENRMLP QGSFRLSSGA DGNNSSLNSP ASFSGHTTPS QQPEPVVHSL KVVWRKLGDA
AGSCPGIRQH LSGNQYKGPM
