ZN485_HUMAN
ID ZN485_HUMAN Reviewed; 441 AA.
AC Q8NCK3; B4DSE6; Q96CL0;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Zinc finger protein 485;
GN Name=ZNF485;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8NCK3; O00560: SDCBP; NbExp=3; IntAct=EBI-12901093, EBI-727004;
CC Q8NCK3; Q8N8Y5: ZFP41; NbExp=3; IntAct=EBI-12901093, EBI-12224489;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NCK3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NCK3-2; Sequence=VSP_055957;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH14161.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK074679; BAC11133.1; -; mRNA.
DR EMBL; AK299707; BAG61608.1; -; mRNA.
DR EMBL; AL645634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC014161; AAH14161.1; ALT_FRAME; mRNA.
DR CCDS; CCDS7205.2; -. [Q8NCK3-1]
DR RefSeq; NP_001305069.1; NM_001318140.1. [Q8NCK3-1]
DR RefSeq; NP_001305070.1; NM_001318141.1. [Q8NCK3-1]
DR RefSeq; NP_001305071.1; NM_001318142.1. [Q8NCK3-2]
DR RefSeq; NP_001305072.1; NM_001318143.1. [Q8NCK3-2]
DR RefSeq; NP_660355.2; NM_145312.3. [Q8NCK3-1]
DR RefSeq; XP_011537800.1; XM_011539498.2. [Q8NCK3-2]
DR AlphaFoldDB; Q8NCK3; -.
DR SMR; Q8NCK3; -.
DR BioGRID; 128671; 30.
DR IntAct; Q8NCK3; 3.
DR iPTMnet; Q8NCK3; -.
DR PhosphoSitePlus; Q8NCK3; -.
DR BioMuta; ZNF485; -.
DR DMDM; 74762554; -.
DR EPD; Q8NCK3; -.
DR jPOST; Q8NCK3; -.
DR MassIVE; Q8NCK3; -.
DR MaxQB; Q8NCK3; -.
DR PaxDb; Q8NCK3; -.
DR PeptideAtlas; Q8NCK3; -.
DR PRIDE; Q8NCK3; -.
DR ProteomicsDB; 5017; -.
DR ProteomicsDB; 72901; -. [Q8NCK3-1]
DR Antibodypedia; 26927; 69 antibodies from 17 providers.
DR DNASU; 220992; -.
DR Ensembl; ENST00000361807.8; ENSP00000354694.3; ENSG00000198298.13. [Q8NCK3-1]
DR Ensembl; ENST00000374435.3; ENSP00000363558.3; ENSG00000198298.13. [Q8NCK3-1]
DR GeneID; 220992; -.
DR KEGG; hsa:220992; -.
DR MANE-Select; ENST00000361807.8; ENSP00000354694.3; NM_145312.4; NP_660355.2.
DR UCSC; uc010qfc.3; human. [Q8NCK3-1]
DR CTD; 220992; -.
DR DisGeNET; 220992; -.
DR GeneCards; ZNF485; -.
DR HGNC; HGNC:23440; ZNF485.
DR HPA; ENSG00000198298; Low tissue specificity.
DR neXtProt; NX_Q8NCK3; -.
DR OpenTargets; ENSG00000198298; -.
DR PharmGKB; PA134887005; -.
DR VEuPathDB; HostDB:ENSG00000198298; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163811; -.
DR HOGENOM; CLU_002678_57_1_1; -.
DR InParanoid; Q8NCK3; -.
DR OMA; SVMMERG; -.
DR PhylomeDB; Q8NCK3; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q8NCK3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8NCK3; -.
DR BioGRID-ORCS; 220992; 10 hits in 1067 CRISPR screens.
DR ChiTaRS; ZNF485; human.
DR GenomeRNAi; 220992; -.
DR Pharos; Q8NCK3; Tdark.
DR PRO; PR:Q8NCK3; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8NCK3; protein.
DR Bgee; ENSG00000198298; Expressed in body of pancreas and 115 other tissues.
DR ExpressionAtlas; Q8NCK3; baseline and differential.
DR Genevisible; Q8NCK3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..441
FT /note="Zinc finger protein 485"
FT /id="PRO_0000223953"
FT DOMAIN 11..82
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 130..152
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 158..180
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 186..208
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 214..236
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..91
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055957"
FT VARIANT 252
FT /note="A -> T (in dbSNP:rs12354886)"
FT /id="VAR_059920"
SQ SEQUENCE 441 AA; 50280 MW; 34AAEC75A350EFE6 CRC64;
MAPRAQIQGP LTFGDVAVAF TRIEWRHLDA AQRALYRDVM LENYGNLVSV GLLSSKPKLI
TQLEQGAEPW TEVREAPSGT HAVEDYWFET KMSALKQSTS EASVLGERTK SVMMEKGLDW
EGRSSTEKNY KCKECGKVFK YNSSFISHQR NHTSEKPHKC KECGIAFMNS SSLLNHHKVH
AGKQPYRCIE CGKFLKKHST FINHQRIHSR EKPHKCIECG KTFRKNSILL SHQRIHTGQK
PYKCNDCGKA FAQNAALTRH ERIHSGEKPF KCNKCGRAFR DNSTVLEHQK IHTGEKPYQC
NECGKAFRKS STLISHQRMH TGEKPYHCSK CGKSFRYSSS FAGHQKTHSG NKPYQCRDCG
KAFTKSSTLT GHQRIHTGEK PYHCKKCGKA FRHSSGLVEH QRLHTGEKPY KCNECGKAFP
RSSALKQHKK IHNKERAMKC S
