ZN486_HUMAN
ID ZN486_HUMAN Reviewed; 463 AA.
AC Q96H40; Q0VG00;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 4.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Zinc finger protein 486;
DE AltName: Full=KRAB domain only protein 2;
GN Name=ZNF486; Synonyms=KRBO2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH08936.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH08936.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
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DR EMBL; AC011447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW84874.1; -; Genomic_DNA.
DR EMBL; BC008936; AAH08936.2; ALT_SEQ; mRNA.
DR EMBL; BC117268; AAI17269.1; -; mRNA.
DR CCDS; CCDS46029.1; -.
DR RefSeq; NP_443084.2; NM_052852.3.
DR AlphaFoldDB; Q96H40; -.
DR SMR; Q96H40; -.
DR BioGRID; 124749; 2.
DR STRING; 9606.ENSP00000335042; -.
DR iPTMnet; Q96H40; -.
DR PhosphoSitePlus; Q96H40; -.
DR BioMuta; ZNF486; -.
DR DMDM; 325511409; -.
DR EPD; Q96H40; -.
DR jPOST; Q96H40; -.
DR MassIVE; Q96H40; -.
DR PaxDb; Q96H40; -.
DR PeptideAtlas; Q96H40; -.
DR PRIDE; Q96H40; -.
DR ProteomicsDB; 76700; -.
DR Antibodypedia; 56810; 89 antibodies from 19 providers.
DR DNASU; 90649; -.
DR Ensembl; ENST00000335117.9; ENSP00000335042.7; ENSG00000256229.8.
DR GeneID; 90649; -.
DR KEGG; hsa:90649; -.
DR MANE-Select; ENST00000335117.9; ENSP00000335042.7; NM_052852.4; NP_443084.2.
DR UCSC; uc002nou.4; human.
DR CTD; 90649; -.
DR GeneCards; ZNF486; -.
DR HGNC; HGNC:20807; ZNF486.
DR HPA; ENSG00000256229; Tissue enhanced (thyroid).
DR neXtProt; NX_Q96H40; -.
DR OpenTargets; ENSG00000256229; -.
DR PharmGKB; PA134919932; -.
DR VEuPathDB; HostDB:ENSG00000256229; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153236; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q96H40; -.
DR OMA; FSTFTTH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96H40; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q96H40; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 90649; 122 hits in 1032 CRISPR screens.
DR GenomeRNAi; 90649; -.
DR Pharos; Q96H40; Tdark.
DR PRO; PR:Q96H40; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96H40; protein.
DR Bgee; ENSG00000256229; Expressed in buccal mucosa cell and 176 other tissues.
DR ExpressionAtlas; Q96H40; baseline and differential.
DR Genevisible; Q96H40; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..463
FT /note="Zinc finger protein 486"
FT /id="PRO_0000047611"
FT DOMAIN 13..84
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 154..176
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 210..232
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 238..260
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 266..288
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 294..316
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 322..344
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 350..372
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 378..400
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 406..428
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 434..456
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 463 AA; 53631 MW; C30AE4D7B0EEEA55 CRC64;
MPGPLRSLEM ESLQFRDVAV EFSLEEWHCL DTAQQNLYRD VMLENYRHLV FLGIIVSKPD
LITCLEQGIK PLTMKRHEMI AKPPVVCSHF AQDLWPEQSI KDSYQKVILR KFEKCGHGNL
HFKKGCESVD ECKLHKRGYN GLNQCLTTTQ SKIFQCGKYV KVFHQFSNSK RHKRRHTEKK
PLKYIEGDKA FNQSSTHTTH KKIDTGEKPY KCEECGKAFN RSSHLTTHKI THTREKPYKC
EECGKVFKYF SSFTTHKKIH SGEKPYICEE CGKAFMYPYT LTTHKIIHTG EQPYKCKECD
KAFNHPATLS SHKKIHTGEK PYTCDKCGKA FISSSILSKH EKIHTGEKPY KCEECGKAFT
RSSHLTMHKI IHTGEKPYKC EECGKAFTWS AGLHKHRRTH TGEKPYKCEE CGKAYTTSSN
LTEHKTTHTG EKPYKCKECG KAFNWSSDLN KHKRIHIGQK PRT
