ZN488_HUMAN
ID ZN488_HUMAN Reviewed; 340 AA.
AC Q96MN9; Q05CE0;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Zinc finger protein 488;
GN Name=ZNF488;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional repressor. Plays a role in oligodendrocyte
CC differentiation, together with OLIG2. Mediates Notch signaling-
CC activated formation of oligodendrocyte precursors. Promotes
CC differentiation of adult neural stem progenitor cells (NSPCs) into
CC mature oligodendrocytes and contributes to remyelination following
CC nerve injury. {ECO:0000250|UniProtKB:Q5HZG9}.
CC -!- SUBUNIT: Interacts with OLIG2. {ECO:0000250|UniProtKB:Q5HZG9}.
CC -!- INTERACTION:
CC Q96MN9; P54253: ATXN1; NbExp=9; IntAct=EBI-948288, EBI-930964;
CC Q96MN9; Q8N9N5: BANP; NbExp=3; IntAct=EBI-948288, EBI-744695;
CC Q96MN9; O75553: DAB1; NbExp=3; IntAct=EBI-948288, EBI-7875264;
CC Q96MN9; Q08379: GOLGA2; NbExp=4; IntAct=EBI-948288, EBI-618309;
CC Q96MN9; Q6A162: KRT40; NbExp=3; IntAct=EBI-948288, EBI-10171697;
CC Q96MN9; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-948288, EBI-716006;
CC Q96MN9; P86479: PRR20C; NbExp=3; IntAct=EBI-948288, EBI-10172814;
CC Q96MN9; Q93062: RBPMS; NbExp=4; IntAct=EBI-948288, EBI-740322;
CC Q96MN9; Q9UFD9: RIMBP3; NbExp=3; IntAct=EBI-948288, EBI-10182375;
CC Q96MN9; Q12933: TRAF2; NbExp=3; IntAct=EBI-948288, EBI-355744;
CC Q96MN9-2; Q92870-2: APBB2; NbExp=3; IntAct=EBI-25831733, EBI-21535880;
CC Q96MN9-2; P54253: ATXN1; NbExp=6; IntAct=EBI-25831733, EBI-930964;
CC Q96MN9-2; P46379-2: BAG6; NbExp=3; IntAct=EBI-25831733, EBI-10988864;
CC Q96MN9-2; Q96A83-2: COL26A1; NbExp=3; IntAct=EBI-25831733, EBI-21553822;
CC Q96MN9-2; Q9NX09: DDIT4; NbExp=3; IntAct=EBI-25831733, EBI-715104;
CC Q96MN9-2; G5E9A7: DMWD; NbExp=3; IntAct=EBI-25831733, EBI-10976677;
CC Q96MN9-2; O14645: DNALI1; NbExp=3; IntAct=EBI-25831733, EBI-395638;
CC Q96MN9-2; Q01658: DR1; NbExp=3; IntAct=EBI-25831733, EBI-750300;
CC Q96MN9-2; P14136: GFAP; NbExp=3; IntAct=EBI-25831733, EBI-744302;
CC Q96MN9-2; P28799: GRN; NbExp=3; IntAct=EBI-25831733, EBI-747754;
CC Q96MN9-2; Q00403: GTF2B; NbExp=3; IntAct=EBI-25831733, EBI-389564;
CC Q96MN9-2; Q9Y5Q9: GTF3C3; NbExp=3; IntAct=EBI-25831733, EBI-1054873;
CC Q96MN9-2; P04792: HSPB1; NbExp=3; IntAct=EBI-25831733, EBI-352682;
CC Q96MN9-2; O60333-2: KIF1B; NbExp=3; IntAct=EBI-25831733, EBI-10975473;
CC Q96MN9-2; O14901: KLF11; NbExp=3; IntAct=EBI-25831733, EBI-948266;
CC Q96MN9-2; P02545: LMNA; NbExp=3; IntAct=EBI-25831733, EBI-351935;
CC Q96MN9-2; P07196: NEFL; NbExp=3; IntAct=EBI-25831733, EBI-475646;
CC Q96MN9-2; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-25831733, EBI-2811583;
CC Q96MN9-2; Q96CV9: OPTN; NbExp=3; IntAct=EBI-25831733, EBI-748974;
CC Q96MN9-2; Q16512: PKN1; NbExp=3; IntAct=EBI-25831733, EBI-602382;
CC Q96MN9-2; D3DTS7: PMP22; NbExp=3; IntAct=EBI-25831733, EBI-25882629;
CC Q96MN9-2; P60891: PRPS1; NbExp=3; IntAct=EBI-25831733, EBI-749195;
CC Q96MN9-2; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-25831733, EBI-396669;
CC Q96MN9-2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-25831733, EBI-5235340;
CC Q96MN9-2; Q86WV8: TSC1; NbExp=3; IntAct=EBI-25831733, EBI-12806590;
CC Q96MN9-2; Q13885: TUBB2A; NbExp=3; IntAct=EBI-25831733, EBI-711595;
CC Q96MN9-2; P31930: UQCRC1; NbExp=3; IntAct=EBI-25831733, EBI-1052596;
CC Q96MN9-2; P61758: VBP1; NbExp=3; IntAct=EBI-25831733, EBI-357430;
CC Q96MN9-2; O76024: WFS1; NbExp=3; IntAct=EBI-25831733, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5HZG9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96MN9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96MN9-2; Sequence=VSP_055961;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK056666; BAB71246.1; -; mRNA.
DR EMBL; AL731561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026895; AAH26895.1; -; mRNA.
DR EMBL; BC051323; AAH51323.1; -; mRNA.
DR CCDS; CCDS73120.1; -. [Q96MN9-1]
DR RefSeq; NP_001333861.1; NM_001346932.1. [Q96MN9-1]
DR RefSeq; NP_001333862.1; NM_001346933.1. [Q96MN9-1]
DR RefSeq; NP_001333863.1; NM_001346934.1. [Q96MN9-1]
DR RefSeq; NP_001333864.1; NM_001346935.1. [Q96MN9-1]
DR RefSeq; NP_001333865.1; NM_001346936.1. [Q96MN9-1]
DR RefSeq; NP_694579.1; NM_153034.3. [Q96MN9-1]
DR RefSeq; XP_006717680.1; XM_006717617.3. [Q96MN9-1]
DR RefSeq; XP_011537546.1; XM_011539244.2. [Q96MN9-1]
DR RefSeq; XP_016871132.1; XM_017015643.1. [Q96MN9-1]
DR AlphaFoldDB; Q96MN9; -.
DR BioGRID; 125620; 22.
DR IntAct; Q96MN9; 43.
DR STRING; 9606.ENSP00000462269; -.
DR iPTMnet; Q96MN9; -.
DR PhosphoSitePlus; Q96MN9; -.
DR BioMuta; ZNF488; -.
DR DMDM; 68566223; -.
DR MassIVE; Q96MN9; -.
DR PaxDb; Q96MN9; -.
DR PeptideAtlas; Q96MN9; -.
DR PRIDE; Q96MN9; -.
DR ProteomicsDB; 77383; -. [Q96MN9-1]
DR Antibodypedia; 72957; 181 antibodies from 22 providers.
DR DNASU; 118738; -.
DR Ensembl; ENST00000585316.3; ENSP00000462269.1; ENSG00000265763.4. [Q96MN9-1]
DR Ensembl; ENST00000591025.1; ENSP00000468133.1; ENSG00000265763.4. [Q96MN9-2]
DR GeneID; 118738; -.
DR KEGG; hsa:118738; -.
DR MANE-Select; ENST00000585316.3; ENSP00000462269.1; NM_153034.4; NP_694579.1.
DR UCSC; uc001jex.3; human. [Q96MN9-1]
DR CTD; 118738; -.
DR DisGeNET; 118738; -.
DR GeneCards; ZNF488; -.
DR HGNC; HGNC:23535; ZNF488.
DR HPA; ENSG00000265763; Group enriched (brain, intestine).
DR neXtProt; NX_Q96MN9; -.
DR OpenTargets; ENSG00000265763; -.
DR PharmGKB; PA134917840; -.
DR VEuPathDB; HostDB:ENSG00000265763; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00890000139463; -.
DR HOGENOM; CLU_070344_0_0_1; -.
DR InParanoid; Q96MN9; -.
DR OMA; VCHEYFR; -.
DR OrthoDB; 1327331at2759; -.
DR PhylomeDB; Q96MN9; -.
DR TreeFam; TF327090; -.
DR PathwayCommons; Q96MN9; -.
DR SignaLink; Q96MN9; -.
DR BioGRID-ORCS; 118738; 9 hits in 1073 CRISPR screens.
DR ChiTaRS; ZNF488; human.
DR GenomeRNAi; 118738; -.
DR Pharos; Q96MN9; Tdark.
DR PRO; PR:Q96MN9; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q96MN9; protein.
DR Bgee; ENSG00000265763; Expressed in C1 segment of cervical spinal cord and 101 other tissues.
DR Genevisible; Q96MN9; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0014003; P:oligodendrocyte development; IBA:GO_Central.
DR GO; GO:0031643; P:positive regulation of myelination; IEA:Ensembl.
DR GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Neurogenesis; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..340
FT /note="Zinc finger protein 488"
FT /id="PRO_0000047612"
FT ZN_FING 275..302
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 317..339
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 72..187
FT /note="Important for transcriptional repression activity"
FT /evidence="ECO:0000250|UniProtKB:Q5HZG9"
FT REGION 77..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 298..305
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 103..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..107
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055961"
FT VARIANT 72
FT /note="A -> V (in dbSNP:rs35618062)"
FT /id="VAR_033571"
FT VARIANT 106
FT /note="P -> L (in dbSNP:rs12251609)"
FT /id="VAR_033572"
FT VARIANT 249
FT /note="P -> S (in dbSNP:rs3814160)"
FT /id="VAR_033573"
SQ SEQUENCE 340 AA; 36962 MW; 0584ABA6A8F36CBF CRC64;
MPEWPPCLSV APALVITMAA GKGAPLSPSA ENRWRLSEPE LGRGCKPVLL EKTNRLGPEA
AVGRAGRDVG SAELALLVAP GKPRPGKPLP PKTRGEQRQS AFTELPRMKD RQVDAQAQER
EHDDPTGQPG APQLTQNIPR GPAGSKVFSV WPSGARSEQR SAFSKPTKRP AERPELTSVF
PAGESADALG ELSGLLNTTD LACWGRLSTP KLLVGDLWNL QALPQNAPLC STFLGAPTLW
LEHTQAQVPP PSSSSTTSWA LLPPTLTSLG LSTQNWCAKC NLSFRLTSDL VFHMRSHHKK
EHAGPDPHSQ KRREEALACP VCQEHFRERH HLSRHMTSHS
