ZN488_MOUSE
ID ZN488_MOUSE Reviewed; 337 AA.
AC Q5HZG9;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Zinc finger protein 488;
GN Name=Znf488; Synonyms=Gm1206, Zfp488;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, INTERACTION WITH OLIG2, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, INDUCTION, AND NUCLEAR LOCALIZATION SIGNAL.
RX PubMed=16908628; DOI=10.1242/dev.02522;
RA Wang S.Z., Dulin J., Wu H., Hurlock E., Lee S.E., Jansson K., Lu Q.R.;
RT "An oligodendrocyte-specific zinc-finger transcription regulator cooperates
RT with Olig2 to promote oligodendrocyte differentiation.";
RL Development 133:3389-3398(2006).
RN [4]
RP FUNCTION.
RX PubMed=22355521; DOI=10.1038/srep00002;
RA Soundarapandian M.M., Selvaraj V., Lo U.G., Golub M.S., Feldman D.H.,
RA Pleasure D.E., Deng W.;
RT "Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells
RT in adult mice after demyelination.";
RL Sci. Rep. 1:2-2(2011).
CC -!- FUNCTION: Transcriptional repressor (PubMed:16908628). Plays a role in
CC oligodendrocyte differentiation, together with OLIG2 (PubMed:16908628,
CC PubMed:22355521). Mediates Notch signaling-activated formation of
CC oligodendrocyte precursors (PubMed:16908628). Promotes differentiation
CC of adult neural stem progenitor cells (NSPCs) into mature
CC oligodendrocytes and contributes to remyelination following nerve
CC injury (PubMed:22355521). {ECO:0000269|PubMed:16908628,
CC ECO:0000269|PubMed:22355521}.
CC -!- SUBUNIT: Interacts with OLIG2. {ECO:0000269|PubMed:16908628}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16908628}.
CC -!- DEVELOPMENTAL STAGE: Detected in differentiated oligodendrocytes, from
CC embryos at 14.5 dpc through to the postnatal stage.
CC {ECO:0000269|PubMed:16908628}.
CC -!- INDUCTION: Up-regulated by OLIG1. {ECO:0000269|PubMed:16908628}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH89025.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC166828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC089025; AAH89025.1; ALT_INIT; mRNA.
DR CCDS; CCDS26930.2; -.
DR RefSeq; NP_001013799.2; NM_001013777.2.
DR RefSeq; XP_006519261.1; XM_006519198.3.
DR AlphaFoldDB; Q5HZG9; -.
DR STRING; 10090.ENSMUSP00000132436; -.
DR PhosphoSitePlus; Q5HZG9; -.
DR PaxDb; Q5HZG9; -.
DR PRIDE; Q5HZG9; -.
DR ProteomicsDB; 275291; -.
DR Antibodypedia; 72957; 181 antibodies from 22 providers.
DR Ensembl; ENSMUST00000166737; ENSMUSP00000132436; ENSMUSG00000044519.
DR GeneID; 382867; -.
DR KEGG; mmu:382867; -.
DR UCSC; uc007tae.1; mouse.
DR CTD; 382867; -.
DR MGI; MGI:2686052; Zfp488.
DR VEuPathDB; HostDB:ENSMUSG00000044519; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00890000139463; -.
DR HOGENOM; CLU_070344_0_0_1; -.
DR InParanoid; Q5HZG9; -.
DR OMA; VCHEYFR; -.
DR OrthoDB; 1327331at2759; -.
DR PhylomeDB; Q5HZG9; -.
DR TreeFam; TF327090; -.
DR BioGRID-ORCS; 382867; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Zfp488; mouse.
DR PRO; PR:Q5HZG9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q5HZG9; protein.
DR Bgee; ENSMUSG00000044519; Expressed in white matter and 24 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0014003; P:oligodendrocyte development; IDA:MGI.
DR GO; GO:0031643; P:positive regulation of myelination; IDA:UniProtKB.
DR GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IDA:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Neurogenesis; Nucleus; Reference proteome;
KW Repeat; Repressor; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..337
FT /note="Zinc finger protein 488"
FT /id="PRO_0000353090"
FT ZN_FING 272..299
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 314..336
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..184
FT /note="Important for transcriptional repression activity"
FT /evidence="ECO:0000269|PubMed:16908628"
FT REGION 146..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 295..302
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768,
FT ECO:0000305|PubMed:16908628"
SQ SEQUENCE 337 AA; 37195 MW; A6E8B187380C7C01 CRC64;
MAAGTSTLLS LSGPADHMAE GKGAPLRPSV EKRWKLMEPK QTQAGMFKKM SLVDSDTAAG
KGSQDEAYTE LSLPTAPNKP RLDRPRACKA YTEQRHNTFT ELSCLQERPG DIQAQTRKLE
NPEGQLGPQQ LPSSFLRASG DGTVCSAWPG APRSEQKSAF SKPAKRPAEK PKRSPMLLAG
GSAEGSWELS GLITTVDIPY WAHLSTFKFM GDFWKLHTLS QNILLCNAFQ GAPTPWLEHT
QVQAPTSSAP SSTASRALLP PTLSSLGLST QNWCAKCNLA FRLTADLVFH MRSHHKREHV
GPDPHSKKRR EEVLTCPVCH EYFRERHHLS RHMASHS
