ZN490_HUMAN
ID ZN490_HUMAN Reviewed; 529 AA.
AC Q9ULM2;
DT 21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2002, sequence version 2.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Zinc finger protein 490;
GN Name=ZNF490; Synonyms=KIAA1198;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10574462; DOI=10.1093/dnares/6.5.337;
RA Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:337-345(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9ULM2; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-1105370, EBI-10171416;
CC Q9ULM2; O95273: CCNDBP1; NbExp=3; IntAct=EBI-1105370, EBI-748961;
CC Q9ULM2; Q8NHQ1: CEP70; NbExp=7; IntAct=EBI-1105370, EBI-739624;
CC Q9ULM2; A1L4K1: FSD2; NbExp=3; IntAct=EBI-1105370, EBI-5661036;
CC Q9ULM2; O76003: GLRX3; NbExp=3; IntAct=EBI-1105370, EBI-374781;
CC Q9ULM2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-1105370, EBI-5916454;
CC Q9ULM2; P54257: HAP1; NbExp=3; IntAct=EBI-1105370, EBI-712814;
CC Q9ULM2; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-1105370, EBI-12012928;
CC Q9ULM2; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-1105370, EBI-10172290;
CC Q9ULM2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-1105370, EBI-10171774;
CC Q9ULM2; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-1105370, EBI-11953334;
CC Q9ULM2; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-1105370, EBI-741037;
CC Q9ULM2; Q99750: MDFI; NbExp=7; IntAct=EBI-1105370, EBI-724076;
CC Q9ULM2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-1105370, EBI-16439278;
CC Q9ULM2; Q5JR59: MTUS2; NbExp=5; IntAct=EBI-1105370, EBI-742948;
CC Q9ULM2; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-1105370, EBI-11522433;
CC Q9ULM2; Q9GZM8: NDEL1; NbExp=6; IntAct=EBI-1105370, EBI-928842;
CC Q9ULM2; Q16623: STX1A; NbExp=3; IntAct=EBI-1105370, EBI-712466;
CC Q9ULM2; Q8NA77: TEX19; NbExp=3; IntAct=EBI-1105370, EBI-13323487;
CC Q9ULM2; Q13077: TRAF1; NbExp=3; IntAct=EBI-1105370, EBI-359224;
CC Q9ULM2; Q8WV44: TRIM41; NbExp=7; IntAct=EBI-1105370, EBI-725997;
CC Q9ULM2; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-1105370, EBI-744794;
CC Q9ULM2; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-1105370, EBI-11957238;
CC Q9ULM2; Q9NQZ6: ZC4H2; NbExp=7; IntAct=EBI-1105370, EBI-747993;
CC Q9ULM2; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-1105370, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA86512.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB033024; BAA86512.1; ALT_INIT; mRNA.
DR EMBL; BC038586; AAH38586.1; -; mRNA.
DR CCDS; CCDS12272.1; -.
DR RefSeq; NP_065765.1; NM_020714.2.
DR AlphaFoldDB; Q9ULM2; -.
DR SMR; Q9ULM2; -.
DR BioGRID; 121544; 48.
DR IntAct; Q9ULM2; 39.
DR MINT; Q9ULM2; -.
DR STRING; 9606.ENSP00000311521; -.
DR iPTMnet; Q9ULM2; -.
DR PhosphoSitePlus; Q9ULM2; -.
DR BioMuta; ZNF490; -.
DR DMDM; 20140911; -.
DR EPD; Q9ULM2; -.
DR jPOST; Q9ULM2; -.
DR MassIVE; Q9ULM2; -.
DR MaxQB; Q9ULM2; -.
DR PaxDb; Q9ULM2; -.
DR PeptideAtlas; Q9ULM2; -.
DR PRIDE; Q9ULM2; -.
DR ProteomicsDB; 85077; -.
DR Antibodypedia; 26054; 86 antibodies from 16 providers.
DR DNASU; 57474; -.
DR Ensembl; ENST00000311437.11; ENSP00000311521.6; ENSG00000188033.10.
DR GeneID; 57474; -.
DR KEGG; hsa:57474; -.
DR MANE-Select; ENST00000311437.11; ENSP00000311521.6; NM_020714.3; NP_065765.1.
DR UCSC; uc002mtz.3; human.
DR CTD; 57474; -.
DR DisGeNET; 57474; -.
DR GeneCards; ZNF490; -.
DR HGNC; HGNC:23705; ZNF490.
DR HPA; ENSG00000188033; Low tissue specificity.
DR neXtProt; NX_Q9ULM2; -.
DR OpenTargets; ENSG00000188033; -.
DR PharmGKB; PA134990049; -.
DR VEuPathDB; HostDB:ENSG00000188033; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164491; -.
DR HOGENOM; CLU_002678_57_1_1; -.
DR InParanoid; Q9ULM2; -.
DR OMA; KPNEYHE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9ULM2; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q9ULM2; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9ULM2; -.
DR BioGRID-ORCS; 57474; 12 hits in 1095 CRISPR screens.
DR GenomeRNAi; 57474; -.
DR Pharos; Q9ULM2; Tdark.
DR PRO; PR:Q9ULM2; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9ULM2; protein.
DR Bgee; ENSG00000188033; Expressed in buccal mucosa cell and 110 other tissues.
DR ExpressionAtlas; Q9ULM2; baseline and differential.
DR Genevisible; Q9ULM2; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..529
FT /note="Zinc finger protein 490"
FT /id="PRO_0000047613"
FT DOMAIN 57..132
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 156..178
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 194..216
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 222..244
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 250..272
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 278..300
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 306..328
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 334..356
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 362..384
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 390..412
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 418..440
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 446..468
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 474..496
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 502..524
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 61340 MW; ECBA528D4808153C CRC64;
MRRNSSLSFQ MERPLEEQVQ SKWSSSQGRT GTGGSDVLQM QNSEHHGQSI KTQTDSISLE
DVAVNFTLEE WALLDPGQRN IYRDVMRATF KNLACIGEKW KDQDIEDEHK NQGRNLRSPM
VEALCENKED CPCGKSTSQI PDLNTNLETP TGLKPCDCSV CGEVFMHQVS LNRHMRSHTE
QKPNECHEYG EKPHKCKECG KTFTRSSSIR THERIHTGEK PYECKECGKA FAFLFSFRNH
IRIHTGETPY ECKECGKAFR YLTALRRHEK NHTGEKPYKC KQCGKAFIYY QPFLTHERTH
TGEKPYECKQ CGKAFSCPTY LRSHEKTHTG EKPFVCRECG RAFFSHSSLR KHVKTHTGVQ
PYTCKKCGEA FKSSSSCEVH ERTHFGEKPY ECKQCGKAFN SSSYLQLHER VHTGEKTYEC
KECGKAFLYS THFRIHERTH TREKPYECKQ CGRVFIYFSH LRRHERSHTG VKPCECKQCG
KAFTCLNSLK VHKRIHTGER PFQCRQCGKA FSYSKSLHVH ERTHSRQKP
