ZN491_HUMAN
ID ZN491_HUMAN Reviewed; 437 AA.
AC Q8N8L2; Q3MJ35; Q8NAT8;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Zinc finger protein 491;
GN Name=ZNF491;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8N8L2; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-12019860, EBI-739624;
CC Q8N8L2; P49760: CLK2; NbExp=3; IntAct=EBI-12019860, EBI-750020;
CC Q8N8L2; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-12019860, EBI-11959885;
CC Q8N8L2; P60409: KRTAP10-7; NbExp=5; IntAct=EBI-12019860, EBI-10172290;
CC Q8N8L2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-12019860, EBI-10171774;
CC Q8N8L2; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-12019860, EBI-11953334;
CC Q8N8L2; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-12019860, EBI-14065470;
CC Q8N8L2; Q99750: MDFI; NbExp=5; IntAct=EBI-12019860, EBI-724076;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC03809.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK092110; BAC03809.1; ALT_SEQ; mRNA.
DR EMBL; AK096593; BAC04824.1; -; mRNA.
DR EMBL; BC101590; AAI01591.1; -; mRNA.
DR EMBL; BC101592; AAI01593.1; -; mRNA.
DR CCDS; CCDS12267.1; -.
DR RefSeq; NP_689569.2; NM_152356.3.
DR RefSeq; XP_005259787.1; XM_005259730.3.
DR AlphaFoldDB; Q8N8L2; -.
DR SMR; Q8N8L2; -.
DR BioGRID; 125952; 21.
DR IntAct; Q8N8L2; 19.
DR STRING; 9606.ENSP00000313443; -.
DR iPTMnet; Q8N8L2; -.
DR PhosphoSitePlus; Q8N8L2; -.
DR BioMuta; ZNF491; -.
DR DMDM; 51316965; -.
DR jPOST; Q8N8L2; -.
DR MassIVE; Q8N8L2; -.
DR MaxQB; Q8N8L2; -.
DR PaxDb; Q8N8L2; -.
DR PeptideAtlas; Q8N8L2; -.
DR PRIDE; Q8N8L2; -.
DR ProteomicsDB; 72434; -.
DR Antibodypedia; 13218; 40 antibodies from 13 providers.
DR DNASU; 126069; -.
DR Ensembl; ENST00000323169.10; ENSP00000313443.5; ENSG00000177599.13.
DR GeneID; 126069; -.
DR KEGG; hsa:126069; -.
DR MANE-Select; ENST00000323169.10; ENSP00000313443.5; NM_152356.4; NP_689569.2.
DR UCSC; uc002mso.2; human.
DR CTD; 126069; -.
DR DisGeNET; 126069; -.
DR GeneCards; ZNF491; -.
DR HGNC; HGNC:23706; ZNF491.
DR HPA; ENSG00000177599; Tissue enhanced (retina).
DR neXtProt; NX_Q8N8L2; -.
DR OpenTargets; ENSG00000177599; -.
DR PharmGKB; PA134982286; -.
DR VEuPathDB; HostDB:ENSG00000177599; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163273; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q8N8L2; -.
DR OMA; WHSSVRI; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N8L2; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q8N8L2; -.
DR SignaLink; Q8N8L2; -.
DR BioGRID-ORCS; 126069; 7 hits in 1061 CRISPR screens.
DR GenomeRNAi; 126069; -.
DR Pharos; Q8N8L2; Tdark.
DR PRO; PR:Q8N8L2; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N8L2; protein.
DR Bgee; ENSG00000177599; Expressed in ganglionic eminence and 93 other tissues.
DR ExpressionAtlas; Q8N8L2; baseline and differential.
DR Genevisible; Q8N8L2; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..437
FT /note="Zinc finger protein 491"
FT /id="PRO_0000047614"
FT ZN_FING 35..59
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 103..125
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 131..153
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 159..181
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 187..209
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 215..237
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 243..265
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..293
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 327..349
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 355..377
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 383..405
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 411..433
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 437 AA; 50950 MW; 1F4BC6E07A031634 CRC64;
MGERLFESAE GSQCGETFTQ VPEDMLNKKT LPGVKSCESG TCGEIFMGYS SFNRNIRTDT
GHQPHKCQKF LEKPYKHKQR RKALSHSHCF RTHERPHTRE KPFDCKECEK SFISPASIRR
YMVTHSGDGP YKCKFCGKAL DCLSLYLTHE RTHTGEKRYE CKQCGKAFSW HSSVRIHERT
HTGEKPYECK ECGKSFNFSS SFRRHERTHT GEKPYKCKEC GKAFNCPSSF HRHERTHTGE
KPYECKLYGK ALSRLISFRR HMRMHTGERP HKCKICGKAF YSPSSFQRHE RSHTGEKPYK
CKQCGKAFTC STSFQYHERT HTGEKPDGCK QCGKAFRSAK YIRIHGRTHT GEKPYECKQC
GKAFHCVSSF HRHERTHAGE KPYECKHCGK AFTCSIYIRI HERIHTGEKP YQCKECGKAF
IRSSYCRKHE RTHTINI
