ZN492_HUMAN
ID ZN492_HUMAN Reviewed; 531 AA.
AC Q9P255; Q08EI7; Q08EI8;
DT 21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Zinc finger protein 492;
DE AltName: Full=Zinc finger protein 115;
GN Name=ZNF492; Synonyms=KIAA1473, ZNF115;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA95997.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB040906; BAA95997.1; ALT_INIT; mRNA.
DR EMBL; BC110575; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS46032.1; -.
DR RefSeq; NP_065906.1; NM_020855.2.
DR AlphaFoldDB; Q9P255; -.
DR SMR; Q9P255; -.
DR BioGRID; 121662; 13.
DR IntAct; Q9P255; 1.
DR STRING; 9606.ENSP00000413660; -.
DR iPTMnet; Q9P255; -.
DR PhosphoSitePlus; Q9P255; -.
DR BioMuta; ZNF492; -.
DR DMDM; 148887468; -.
DR jPOST; Q9P255; -.
DR MassIVE; Q9P255; -.
DR MaxQB; Q9P255; -.
DR PaxDb; Q9P255; -.
DR PeptideAtlas; Q9P255; -.
DR PRIDE; Q9P255; -.
DR ProteomicsDB; 83732; -.
DR Antibodypedia; 55051; 63 antibodies from 13 providers.
DR DNASU; 57615; -.
DR Ensembl; ENST00000456783.3; ENSP00000413660.2; ENSG00000229676.3.
DR GeneID; 57615; -.
DR KEGG; hsa:57615; -.
DR MANE-Select; ENST00000456783.3; ENSP00000413660.2; NM_020855.3; NP_065906.1.
DR UCSC; uc002nqw.3; human.
DR CTD; 57615; -.
DR DisGeNET; 57615; -.
DR GeneCards; ZNF492; -.
DR HGNC; HGNC:23707; ZNF492.
DR HPA; ENSG00000229676; Tissue enhanced (bone marrow, testis).
DR neXtProt; NX_Q9P255; -.
DR OpenTargets; ENSG00000229676; -.
DR PharmGKB; PA134940205; -.
DR VEuPathDB; HostDB:ENSG00000229676; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153236; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q9P255; -.
DR OMA; KRNHTGV; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9P255; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q9P255; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9P255; -.
DR BioGRID-ORCS; 57615; 529 hits in 1013 CRISPR screens.
DR GenomeRNAi; 57615; -.
DR Pharos; Q9P255; Tdark.
DR PRO; PR:Q9P255; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9P255; protein.
DR Bgee; ENSG00000229676; Expressed in ventricular zone and 44 other tissues.
DR Genevisible; Q9P255; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..531
FT /note="Zinc finger protein 492"
FT /id="PRO_0000047615"
FT DOMAIN 1..43
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 141..163
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 169..191
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 12; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 106
FT /note="T -> K (in dbSNP:rs11672238)"
FT /id="VAR_052845"
SQ SEQUENCE 531 AA; 61158 MW; DF36DD14AD8570FD CRC64;
MLENYRNLVF VGIAASKPDL ITCLEQGKEP WNVKRHEMVA EPPVVCSYFA RDLWPKQGKK
NYFQKVILRR YKKCGCENLQ LRKYCKSMDE CKVHKECYNG LNQCLTTTQN KIFQCDKYVK
VFHKFSNSNR HTIRHTGKKS FKCKECEKSF CMLSHLAQHK RIHSGEKPYK CKECGKAYNE
TSNLSTHKRI HTGKKPYKCE ECGKAFNRLS HLTTHKIIHT GKKPYKCEEC GKAFNQSANL
TTHKRIHTGE KPYKCEECGR AFSQSSTLTA HKIIHAGEKP YKCEECGKAF SQSSTLTTHK
IIHTGEKFYK CEECGKAFSQ LSHLTTHKRI HSGEKPYKCE ECGKAFKQSS TLTTHKRIHA
GEKFYKCEVC SKAFSRFSHL TTHKRIHTGE KPYKCEECGK AFNLSSQLTT HKIIHTGEKP
YKCEECGKAF NQSSTLSKHK VIHTGEKPYK YEECGKAFNQ SSHLTTHKMI HTGEKPYKCE
ECGKAFNNSS ILNRHKMIHT GEKLYKPESC NNACDNIAKI SKYKRNCAGE K
