ZN497_HUMAN
ID ZN497_HUMAN Reviewed; 498 AA.
AC Q6ZNH5; Q05AG8; Q0VF48; Q6ZTD2; Q9UIA8;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Zinc finger protein 497;
GN Name=ZNF497;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-174.
RC TISSUE=Cerebellum, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-174.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 176-329.
RA Ma X., Huang B.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q6ZNH5; P07339: CTSD; NbExp=4; IntAct=EBI-10486136, EBI-2115097;
CC Q6ZNH5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10486136, EBI-3867333;
CC Q6ZNH5; G5E9A7: DMWD; NbExp=3; IntAct=EBI-10486136, EBI-10976677;
CC Q6ZNH5; Q92997: DVL3; NbExp=3; IntAct=EBI-10486136, EBI-739789;
CC Q6ZNH5; Q9NZ52-2: GGA3; NbExp=3; IntAct=EBI-10486136, EBI-12075758;
CC Q6ZNH5; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10486136, EBI-5916454;
CC Q6ZNH5; P28799: GRN; NbExp=3; IntAct=EBI-10486136, EBI-747754;
CC Q6ZNH5; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-10486136, EBI-10961706;
CC Q6ZNH5; P42858: HTT; NbExp=9; IntAct=EBI-10486136, EBI-466029;
CC Q6ZNH5; Q5VWX1: KHDRBS2; NbExp=3; IntAct=EBI-10486136, EBI-742808;
CC Q6ZNH5; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10486136, EBI-10975473;
CC Q6ZNH5; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10486136, EBI-11959885;
CC Q6ZNH5; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10486136, EBI-11749135;
CC Q6ZNH5; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10486136, EBI-10171774;
CC Q6ZNH5; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10486136, EBI-10172052;
CC Q6ZNH5; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-10486136, EBI-10176379;
CC Q6ZNH5; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10486136, EBI-11953334;
CC Q6ZNH5; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-10486136, EBI-739863;
CC Q6ZNH5; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-10486136, EBI-11958132;
CC Q6ZNH5; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10486136, EBI-1043191;
CC Q6ZNH5; P02545: LMNA; NbExp=3; IntAct=EBI-10486136, EBI-351935;
CC Q6ZNH5; P23508: MCC; NbExp=3; IntAct=EBI-10486136, EBI-307531;
CC Q6ZNH5; Q99750: MDFI; NbExp=3; IntAct=EBI-10486136, EBI-724076;
CC Q6ZNH5; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-10486136, EBI-10172526;
CC Q6ZNH5; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-10486136, EBI-11522433;
CC Q6ZNH5; P35240: NF2; NbExp=3; IntAct=EBI-10486136, EBI-1014472;
CC Q6ZNH5; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10486136, EBI-22310682;
CC Q6ZNH5; Q9H4L5: OSBPL3; NbExp=3; IntAct=EBI-10486136, EBI-1051317;
CC Q6ZNH5; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-10486136, EBI-79165;
CC Q6ZNH5; P60891: PRPS1; NbExp=3; IntAct=EBI-10486136, EBI-749195;
CC Q6ZNH5; Q16825: PTPN21; NbExp=3; IntAct=EBI-10486136, EBI-2860264;
CC Q6ZNH5; Q96QR8: PURB; NbExp=3; IntAct=EBI-10486136, EBI-2880222;
CC Q6ZNH5; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10486136, EBI-396669;
CC Q6ZNH5; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10486136, EBI-5235340;
CC Q6ZNH5; O00204: SULT2B1; NbExp=3; IntAct=EBI-10486136, EBI-749441;
CC Q6ZNH5; Q63HR2: TNS2; NbExp=3; IntAct=EBI-10486136, EBI-949753;
CC Q6ZNH5; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-10486136, EBI-725997;
CC Q6ZNH5; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-10486136, EBI-11957238;
CC Q6ZNH5; O76024: WFS1; NbExp=3; IntAct=EBI-10486136, EBI-720609;
CC Q6ZNH5; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-10486136, EBI-742740;
CC Q6ZNH5; Q8WTR7: ZNF473; NbExp=3; IntAct=EBI-10486136, EBI-751409;
CC Q6ZNH5; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-10486136, EBI-11035148;
CC Q6ZNH5; Q9NQZ8: ZNF71; NbExp=5; IntAct=EBI-10486136, EBI-7138235;
CC Q6ZNH5; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-10486136, EBI-10240849;
CC Q6ZNH5; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-10486136, EBI-5667516;
CC Q6ZNH5; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-10486136, EBI-11962574;
CC Q6ZNH5; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-10486136, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK126727; BAC86660.1; -; mRNA.
DR EMBL; AK131209; BAD18400.1; -; mRNA.
DR EMBL; CH471135; EAW72578.1; -; Genomic_DNA.
DR EMBL; BC118983; AAI18984.1; -; mRNA.
DR EMBL; BC125273; AAI25274.1; -; mRNA.
DR EMBL; AF064790; AAF16412.1; -; Genomic_DNA.
DR CCDS; CCDS12977.1; -.
DR RefSeq; NP_001193938.1; NM_001207009.1.
DR RefSeq; NP_940860.2; NM_198458.2.
DR AlphaFoldDB; Q6ZNH5; -.
DR SMR; Q6ZNH5; -.
DR BioGRID; 127835; 186.
DR IntAct; Q6ZNH5; 47.
DR iPTMnet; Q6ZNH5; -.
DR PhosphoSitePlus; Q6ZNH5; -.
DR BioMuta; ZNF497; -.
DR DMDM; 229462815; -.
DR jPOST; Q6ZNH5; -.
DR MassIVE; Q6ZNH5; -.
DR PaxDb; Q6ZNH5; -.
DR PeptideAtlas; Q6ZNH5; -.
DR PRIDE; Q6ZNH5; -.
DR ProteomicsDB; 68026; -.
DR Antibodypedia; 19686; 38 antibodies from 19 providers.
DR DNASU; 162968; -.
DR Ensembl; ENST00000311044.8; ENSP00000311183.2; ENSG00000174586.11.
DR Ensembl; ENST00000425453.3; ENSP00000402815.2; ENSG00000174586.11.
DR GeneID; 162968; -.
DR KEGG; hsa:162968; -.
DR MANE-Select; ENST00000311044.8; ENSP00000311183.2; NM_198458.3; NP_940860.2.
DR UCSC; uc002qsh.3; human.
DR CTD; 162968; -.
DR GeneCards; ZNF497; -.
DR HGNC; HGNC:23714; ZNF497.
DR HPA; ENSG00000174586; Low tissue specificity.
DR neXtProt; NX_Q6ZNH5; -.
DR OpenTargets; ENSG00000174586; -.
DR PharmGKB; PA134994387; -.
DR VEuPathDB; HostDB:ENSG00000174586; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000165876; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q6ZNH5; -.
DR OMA; HHRLTHT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZNH5; -.
DR TreeFam; TF337005; -.
DR PathwayCommons; Q6ZNH5; -.
DR SignaLink; Q6ZNH5; -.
DR BioGRID-ORCS; 162968; 18 hits in 1105 CRISPR screens.
DR GenomeRNAi; 162968; -.
DR Pharos; Q6ZNH5; Tdark.
DR PRO; PR:Q6ZNH5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZNH5; protein.
DR Bgee; ENSG00000174586; Expressed in right uterine tube and 90 other tissues.
DR ExpressionAtlas; Q6ZNH5; baseline and differential.
DR Genevisible; Q6ZNH5; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..498
FT /note="Zinc finger protein 497"
FT /id="PRO_0000047618"
FT ZN_FING 106..128
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 134..156
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 162..184
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 190..212
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 218..240
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..268
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 274..296
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 302..324
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 330..352
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..380
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 386..408
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 414..436
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 442..464
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 470..492
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 30..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 174
FT /note="H -> Q (in dbSNP:rs12609654)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_055270"
FT CONFLICT 212..214
FT /note="HTG -> RA (in Ref. 4; AAF16412)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="T -> A (in Ref. 4; AAF16412)"
FT /evidence="ECO:0000305"
FT CONFLICT 320
FT /note="H -> Y (in Ref. 4; AAF16412)"
FT /evidence="ECO:0000305"
FT CONFLICT 367
FT /note="F -> S (in Ref. 1; BAC86660)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 498 AA; 54721 MW; AAC4DD81A06CECFA CRC64;
MESPRGWTLQ VAPEEGQVLC NVKTATRGLS EGAVSGGWGA WENSTEVPRE AGDGQRQQAT
LGAADEQGGP GRELGPADGG RDGAGPRSEP ADRALRPSPL PEEPGCRCGE CGKAFSQGSY
LLQHRRVHTG EKPYTCPECG KAFAWSSNLS QHQRIHSGEK PYACRECGKA FRAHSQLIHH
QETHSGLKPF RCPDCGKSFG RSTTLVQHRR THTGEKPYEC PECGKAFSWN SNFLEHRRVH
TGARPHACRD CGKAFSQSSN LAEHLKIHAG ARPHACPDCG KAFVRVAGLR QHRRTHSSEK
PFPCAECGKA FRESSQLLQH QRTHTGERPF ECAECGQAFV MGSYLAEHRR VHTGEKPHAC
AQCGKAFSQR SNLLSHRRTH SGAKPFACAD CGKAFRGSSG LAHHRLSHTG ERPFACAECG
KAFRGSSELR QHQRLHSGER PFVCAHCSKA FVRKSELLSH RRTHTGERPY ACGECGKPFS
HRCNLNEHQK RHGGRAAP
