ZN501_HUMAN
ID ZN501_HUMAN Reviewed; 271 AA.
AC Q96CX3; B4DLY7; Q96NU9;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Zinc finger protein 501;
DE AltName: Full=Zinc finger protein 52;
GN Name=ZNF501; Synonyms=ZNF52;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP VAL-17.
RC TISSUE=Adrenal gland, and Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryonic carcinoma, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=29851555; DOI=10.1091/mbc.e17-11-0693;
RA Serebrenik Y.V., Hellerschmied D., Toure M., Lopez-Giraldez F.,
RA Brookner D., Crews C.M.;
RT "Targeted protein unfolding uncovers a Golgi-specific transcriptional
RT stress response.";
RL Mol. Biol. Cell 29:1284-1298(2018).
CC -!- FUNCTION: May be involved in transcriptional regulation. Essential for
CC Golgi structural integrity (PubMed:29851555).
CC {ECO:0000269|PubMed:29851555}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29851555}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:29851555}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96CX3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96CX3-2; Sequence=VSP_010173;
CC -!- INDUCTION: Up-regulated by Golgi stress-inducing agent nigericin.
CC {ECO:0000269|PubMed:29851555}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to exon skipping. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK054613; BAB70773.1; -; mRNA.
DR EMBL; AK297216; BAG59699.1; -; mRNA.
DR EMBL; BC013762; AAH13762.2; -; mRNA.
DR CCDS; CCDS2720.2; -. [Q96CX3-1]
DR RefSeq; NP_001245209.1; NM_001258280.1. [Q96CX3-1]
DR RefSeq; NP_659481.2; NM_145044.3. [Q96CX3-1]
DR AlphaFoldDB; Q96CX3; -.
DR SMR; Q96CX3; -.
DR BioGRID; 125439; 10.
DR IntAct; Q96CX3; 5.
DR STRING; 9606.ENSP00000482632; -.
DR iPTMnet; Q96CX3; -.
DR PhosphoSitePlus; Q96CX3; -.
DR BioMuta; ZNF501; -.
DR DMDM; 118597385; -.
DR EPD; Q96CX3; -.
DR jPOST; Q96CX3; -.
DR MassIVE; Q96CX3; -.
DR PaxDb; Q96CX3; -.
DR PeptideAtlas; Q96CX3; -.
DR PRIDE; Q96CX3; -.
DR ProteomicsDB; 76238; -. [Q96CX3-1]
DR ProteomicsDB; 76239; -. [Q96CX3-2]
DR Antibodypedia; 29479; 43 antibodies from 14 providers.
DR DNASU; 115560; -.
DR Ensembl; ENST00000396048.6; ENSP00000379363.2; ENSG00000186446.12. [Q96CX3-1]
DR Ensembl; ENST00000620116.5; ENSP00000482632.1; ENSG00000186446.12. [Q96CX3-1]
DR Ensembl; ENST00000625592.3; ENSP00000485862.1; ENSG00000281661.3. [Q96CX3-1]
DR Ensembl; ENST00000627775.2; ENSP00000487032.1; ENSG00000281661.3. [Q96CX3-1]
DR GeneID; 115560; -.
DR KEGG; hsa:115560; -.
DR MANE-Select; ENST00000620116.5; ENSP00000482632.1; NM_001258280.2; NP_001245209.1.
DR UCSC; uc003cnu.3; human. [Q96CX3-1]
DR CTD; 115560; -.
DR DisGeNET; 115560; -.
DR GeneCards; ZNF501; -.
DR HGNC; HGNC:23717; ZNF501.
DR HPA; ENSG00000186446; Low tissue specificity.
DR neXtProt; NX_Q96CX3; -.
DR OpenTargets; ENSG00000186446; -.
DR PharmGKB; PA134959192; -.
DR VEuPathDB; HostDB:ENSG00000186446; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153104; -.
DR HOGENOM; CLU_002678_2_1_1; -.
DR InParanoid; Q96CX3; -.
DR OMA; SVCLTRH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96CX3; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q96CX3; -.
DR SignaLink; Q96CX3; -.
DR BioGRID-ORCS; 115560; 31 hits in 1031 CRISPR screens.
DR ChiTaRS; ZNF501; human.
DR GenomeRNAi; 115560; -.
DR Pharos; Q96CX3; Tdark.
DR PRO; PR:Q96CX3; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96CX3; protein.
DR Bgee; ENSG00000186446; Expressed in ventricular zone and 109 other tissues.
DR Genevisible; Q96CX3; HS.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0007030; P:Golgi organization; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..271
FT /note="Zinc finger protein 501"
FT /id="PRO_0000047621"
FT ZN_FING 22..44
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 50..72
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 78..100
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 106..128
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 134..156
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 162..184
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 190..212
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 218..240
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..268
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 144..199
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_010173"
FT VARIANT 17
FT /note="M -> V (in dbSNP:rs4682752)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_024219"
FT VARIANT 147
FT /note="I -> V (in dbSNP:rs58211979)"
FT /id="VAR_061952"
SQ SEQUENCE 271 AA; 31179 MW; 090AA309637BD8AA CRC64;
MNSSQISLRM KHGRVNMQKK PSKCSECGKF FTQRSSLTQH QRIHRGEKPY VCSECGSCFR
KQSNLTQHLR IHTGEKPYKC NECEKAFQTK AILVQHLRIH TGEKPYKCNE CGKAFCQSPS
LIKHQRIHTG EKPYKCTECG KAFSQSICLT RHQRSHSGDK PFKCNECGKA FNQSACLMQH
QRIHSGEKPY TCTECGKAFT QNSSLVEHER THTGEKLYKC SECEKTFRKQ AHLSEHYRIH
TGEKPYECVG CGKSFRHSSA LLRHQRLHAG E
