ZN503_HUMAN
ID ZN503_HUMAN Reviewed; 646 AA.
AC Q96F45; Q8NAC5; Q96E25; Q96IJ0;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Zinc finger protein 503;
GN Name=ZNF503; Synonyms=NOLZ1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-646 (ISOFORM 1).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- FUNCTION: May function as a transcriptional repressor. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96F45; Q03989: ARID5A; NbExp=3; IntAct=EBI-8832437, EBI-948603;
CC Q96F45; Q86V38: ATN1; NbExp=3; IntAct=EBI-8832437, EBI-11954292;
CC Q96F45; Q86UW9: DTX2; NbExp=3; IntAct=EBI-8832437, EBI-740376;
CC Q96F45; O75593: FOXH1; NbExp=3; IntAct=EBI-8832437, EBI-1759806;
CC Q96F45; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-8832437, EBI-12811111;
CC Q96F45; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-8832437, EBI-3957694;
CC Q96F45; Q3LI66: KRTAP6-2; NbExp=5; IntAct=EBI-8832437, EBI-11962084;
CC Q96F45; O75360: PROP1; NbExp=3; IntAct=EBI-8832437, EBI-9027467;
CC Q96F45; Q96A09: TENT5B; NbExp=3; IntAct=EBI-8832437, EBI-752030;
CC Q96F45; Q08117-2: TLE5; NbExp=3; IntAct=EBI-8832437, EBI-11741437;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96F45-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96F45-2; Sequence=VSP_026395;
CC Name=3;
CC IsoId=Q96F45-3; Sequence=VSP_026394;
CC -!- SIMILARITY: Belongs to the Elbow/Noc family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC03999.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC007494; AAH07494.1; -; mRNA.
DR EMBL; BC011625; AAH11625.1; -; mRNA.
DR EMBL; BC013011; AAH13011.1; -; mRNA.
DR EMBL; BC021165; AAH21165.1; -; mRNA.
DR EMBL; AK092897; BAC03999.1; ALT_INIT; mRNA.
DR CCDS; CCDS7350.1; -. [Q96F45-1]
DR RefSeq; NP_116161.2; NM_032772.5. [Q96F45-1]
DR AlphaFoldDB; Q96F45; -.
DR BioGRID; 124306; 50.
DR IntAct; Q96F45; 37.
DR MINT; Q96F45; -.
DR STRING; 9606.ENSP00000361602; -.
DR iPTMnet; Q96F45; -.
DR PhosphoSitePlus; Q96F45; -.
DR BioMuta; ZNF503; -.
DR DMDM; 74762652; -.
DR EPD; Q96F45; -.
DR jPOST; Q96F45; -.
DR MassIVE; Q96F45; -.
DR MaxQB; Q96F45; -.
DR PaxDb; Q96F45; -.
DR PeptideAtlas; Q96F45; -.
DR PRIDE; Q96F45; -.
DR ProteomicsDB; 76493; -. [Q96F45-1]
DR ProteomicsDB; 76494; -. [Q96F45-2]
DR ProteomicsDB; 76495; -. [Q96F45-3]
DR Antibodypedia; 29703; 150 antibodies from 21 providers.
DR DNASU; 84858; -.
DR Ensembl; ENST00000372524.5; ENSP00000361602.4; ENSG00000165655.17. [Q96F45-1]
DR GeneID; 84858; -.
DR KEGG; hsa:84858; -.
DR MANE-Select; ENST00000372524.5; ENSP00000361602.4; NM_032772.6; NP_116161.2.
DR UCSC; uc001jxg.4; human. [Q96F45-1]
DR CTD; 84858; -.
DR DisGeNET; 84858; -.
DR GeneCards; ZNF503; -.
DR HGNC; HGNC:23589; ZNF503.
DR HPA; ENSG00000165655; Low tissue specificity.
DR MIM; 613902; gene.
DR neXtProt; NX_Q96F45; -.
DR OpenTargets; ENSG00000165655; -.
DR PharmGKB; PA134904334; -.
DR VEuPathDB; HostDB:ENSG00000165655; -.
DR eggNOG; ENOG502QUYV; Eukaryota.
DR GeneTree; ENSGT00390000014618; -.
DR HOGENOM; CLU_035082_1_0_1; -.
DR InParanoid; Q96F45; -.
DR OMA; SDICVAW; -.
DR OrthoDB; 1163882at2759; -.
DR PhylomeDB; Q96F45; -.
DR TreeFam; TF324968; -.
DR PathwayCommons; Q96F45; -.
DR SignaLink; Q96F45; -.
DR SIGNOR; Q96F45; -.
DR BioGRID-ORCS; 84858; 20 hits in 1101 CRISPR screens.
DR ChiTaRS; ZNF503; human.
DR GenomeRNAi; 84858; -.
DR Pharos; Q96F45; Tbio.
DR PRO; PR:Q96F45; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q96F45; protein.
DR Bgee; ENSG00000165655; Expressed in renal medulla and 183 other tissues.
DR Genevisible; Q96F45; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070315; P:G1 to G0 transition involved in cell differentiation; IDA:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0061351; P:neural precursor cell proliferation; IEA:Ensembl.
DR InterPro; IPR022129; Tscrpt_rep_NocA-like.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF12402; nlz1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Metal-binding; Methylation; Nucleus;
KW Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..646
FT /note="Zinc finger protein 503"
FT /id="PRO_0000292204"
FT ZN_FING 514..542
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 102
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TMA2"
FT MOD_RES 209
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q7TMA2"
FT MOD_RES 231
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TMA2"
FT MOD_RES 237
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TMA2"
FT MOD_RES 636
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q7TMA2"
FT VAR_SEQ 130..492
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026394"
FT VAR_SEQ 233..269
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026395"
FT VARIANT 509
FT /note="N -> K (in dbSNP:rs35764982)"
FT /id="VAR_032951"
SQ SEQUENCE 646 AA; 62555 MW; F7F341E6C8170B85 CRC64;
MSTAPSLSAL RSSKHSGGGG GGGGGGGADP AWTSALSGNS SGPGPGSSPA GSTKPFVHAV
PPSDPLRQAN RLPIKVLKML TARTGHILHP EYLQPLPSTP VSPIELDAKK SPLALLAQTC
SQIGKPDPSP SSKLSSVASN GGGAGGAGGG AAGDKDTKSG PLKLSDIGVE DKSSFKPYSK
PGSDKKEPGG GGGGGGGGGG GGGGVSSEKS GFRVPSATCQ PFTPRTGSPS SSASACSPGG
MLSSAGGAPE GKDDKKDTDV GGGGKGTGGA SAEGGPTGLA HGRISCGGGI NVDVNQHPDG
GPGGKALGSD CGGSSGSSSG SGPSAPTSSS VLGSGLVAPV SPYKPGQTVF PLPPAGMTYP
GSLAGAYAGY PPQFLPHGVA LDPTKPGSLV GAQLAAAAAG SLGCSKPAGS SPLAGASPPS
VMTASLCRDP YCLSYHCASH LAGAAAASAS CAHDPAAAAA ALKSGYPLVY PTHPLHGVHS
SLTAAAAAGA TPPSLAGHPL YPYGFMLPND PLPHICNWVS ANGPCDKRFA TSEELLSHLR
THTAFPGTDK LLSGYPSSSS LASAAAAAMA CHMHIPTSGA PGSPGTLALR SPHHALGLSS
RYHPYSKSPL PTPGAPVPVP AATGPYYSPY ALYGQRLTTA SALGYQ
