ZN503_MOUSE
ID ZN503_MOUSE Reviewed; 652 AA.
AC Q7TMA2; Q8VCV4;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Zinc finger protein 503;
DE AltName: Full=Zinc finger protein Nolz-1;
GN Name=Znf503; Synonyms=Nolz1, Zfp503;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Head, and Medulla oblongata;
RX PubMed=14983057; DOI=10.1073/pnas.0308645100;
RA Chang C.W., Tsai C.W., Wang H.F., Tsai H.C., Chen H.Y., Tsai T.F.,
RA Takahashi H., Li H.Y., Fann M.J., Yang C.W., Hayashizaki Y., Saito T.,
RA Liu F.C.;
RT "Identification of a developmentally regulated striatum-enriched zinc-
RT finger gene, Nolz-1, in the mammalian brain.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2613-2618(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-235 AND SER-241, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-213, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [5]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-642, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: May function as a transcriptional repressor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7TMA2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TMA2-2; Sequence=VSP_026396, VSP_026397, VSP_026398;
CC -!- SIMILARITY: Belongs to the Elbow/Noc family. {ECO:0000305}.
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DR EMBL; AY281290; AAP44411.1; -; mRNA.
DR EMBL; AY281291; AAP44412.1; -; mRNA.
DR EMBL; BC018484; AAH18484.1; -; mRNA.
DR EMBL; BC058952; AAH58952.1; -; mRNA.
DR EMBL; BC066027; AAH66027.1; -; mRNA.
DR CCDS; CCDS36822.1; -. [Q7TMA2-1]
DR RefSeq; NP_663434.2; NM_145459.3. [Q7TMA2-1]
DR AlphaFoldDB; Q7TMA2; -.
DR STRING; 10090.ENSMUSP00000046641; -.
DR iPTMnet; Q7TMA2; -.
DR PhosphoSitePlus; Q7TMA2; -.
DR MaxQB; Q7TMA2; -.
DR PaxDb; Q7TMA2; -.
DR PeptideAtlas; Q7TMA2; -.
DR PRIDE; Q7TMA2; -.
DR ProteomicsDB; 275080; -. [Q7TMA2-1]
DR ProteomicsDB; 275081; -. [Q7TMA2-2]
DR Antibodypedia; 29703; 150 antibodies from 21 providers.
DR DNASU; 218820; -.
DR Ensembl; ENSMUST00000043409; ENSMUSP00000046641; ENSMUSG00000039081. [Q7TMA2-1]
DR GeneID; 218820; -.
DR KEGG; mmu:218820; -.
DR UCSC; uc007slv.1; mouse. [Q7TMA2-1]
DR CTD; 218820; -.
DR MGI; MGI:1353644; Zfp503.
DR VEuPathDB; HostDB:ENSMUSG00000039081; -.
DR eggNOG; ENOG502QUYV; Eukaryota.
DR GeneTree; ENSGT00390000014618; -.
DR HOGENOM; CLU_035082_1_0_1; -.
DR InParanoid; Q7TMA2; -.
DR OMA; SDICVAW; -.
DR OrthoDB; 1163882at2759; -.
DR PhylomeDB; Q7TMA2; -.
DR TreeFam; TF324968; -.
DR BioGRID-ORCS; 218820; 4 hits in 69 CRISPR screens.
DR ChiTaRS; Zfp503; mouse.
DR PRO; PR:Q7TMA2; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q7TMA2; protein.
DR Bgee; ENSMUSG00000039081; Expressed in indifferent gonad and 290 other tissues.
DR Genevisible; Q7TMA2; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070315; P:G1 to G0 transition involved in cell differentiation; IMP:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0061351; P:neural precursor cell proliferation; IMP:UniProtKB.
DR InterPro; IPR022129; Tscrpt_rep_NocA-like.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF12402; nlz1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Metal-binding; Methylation; Nucleus;
KW Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..652
FT /note="Zinc finger protein 503"
FT /id="PRO_0000292205"
FT ZN_FING 520..548
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 107
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 213
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 235
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 642
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 17..21
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026396"
FT VAR_SEQ 270..372
FT /note="SKGSGGASADGVPAGLGHGRISCGGGINVDVNQHSEGGPGGKALGSDCGGSS
FT SSSSGSGPSAPTSSSVLGSGLVAPVSPYKPGQTVFPLPPAGMTYPGSLAGA -> AGAC
FT RHRTILLPLCPLRTETDHCLRTGVSVRAAQRNLERGRIWGMGGAREGQDPSEVPDTRRG
FT RRPGLRKGKESLNLTYPPNHRDRESLDAKLLLHPYSPNQTL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026397"
FT VAR_SEQ 373..652
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026398"
SQ SEQUENCE 652 AA; 63036 MW; DBAFA225ED00D52F CRC64;
MSTAPSLSAL RSSKHSGGGG GGGGGGGSGG GSADPAWTSA LSGNCSGHGP GSSPAGSTKP
FVHAVPPSDP LRQANRLPIK VLKMLTARTG HILHPEYLQP LPSTPVSPIE LDAKKSPLAL
LAQTCSQIGK PDPSPSSKLS SVASNGGGAG GAGNGAGGDK DAKSGPLKLS DIGVEDKSSF
KPYSKPGSDK KEPGGGGGGG GGGGGGGGVA AEKSGFRVPS ATCQPFTPRT GSPSSSASAC
SPGGMLPSAG GGPEGKDDKK DPEAGGGGSS KGSGGASADG VPAGLGHGRI SCGGGINVDV
NQHSEGGPGG KALGSDCGGS SSSSSGSGPS APTSSSVLGS GLVAPVSPYK PGQTVFPLPP
AGMTYPGSLA GAYAGYPPQF LPHGVALDPT KPGSLVGAQL AAAAAGSLGC SKPAGSSPLA
GASPPSVMTA SLCRDPYCLS YHCASHLAGA AAASASCAHD PAAAAAALKS GYPLVYPTHP
LHGVHSSLTA AAAAGATPPS LAGHPLYPYG FMLPNDPLPH ICNWVSANGP CDKRFATSEE
LLSHLRTHTA FPGTDKLLSG YPSSSSLASA AAAAMACHMH IPTSGAPGSP GTLALRSPHH
ALGLSSRYHP YSKSPLPTPG APVPVPAATG PYYSPYALYG QRLTTASALG YQ
