ID   ZN503_XENTR             Reviewed;         541 AA.
AC   Q05AQ8;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Zinc finger protein 503;
GN   Name=znf503;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Elbow/Noc family. {ECO:0000305}.
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DR   EMBL; BC124040; AAI24041.1; -; mRNA.
DR   RefSeq; NP_001072698.1; NM_001079230.1.
DR   AlphaFoldDB; Q05AQ8; -.
DR   STRING; 8364.ENSXETP00000051105; -.
DR   PaxDb; Q05AQ8; -.
DR   DNASU; 780155; -.
DR   GeneID; 780155; -.
DR   KEGG; xtr:780155; -.
DR   CTD; 84858; -.
DR   Xenbase; XB-GENE-1005005; znf503.
DR   eggNOG; ENOG502QUYV; Eukaryota.
DR   HOGENOM; CLU_035082_1_0_1; -.
DR   InParanoid; Q05AQ8; -.
DR   OMA; SDICVAW; -.
DR   OrthoDB; 1163882at2759; -.
DR   PhylomeDB; Q05AQ8; -.
DR   TreeFam; TF324968; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009866; Expressed in neurula embryo and 12 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IEA:Ensembl.
DR   GO; GO:0030902; P:hindbrain development; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR022129; Tscrpt_rep_NocA-like.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF12402; nlz1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..541
FT                   /note="Zinc finger protein 503"
FT                   /id="PRO_0000292207"
FT   ZN_FING         411..439
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          97..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          474..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..159
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..193
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   541 AA;  55930 MW;  ECD66E5339C04D8B CRC64;
     MSNSPLGSGS RISHFTTEST DRGDERASFS SRAFIHTVPP SDPQRQAGRL PIKVLKMLTA
     RGGHILHPEY LQPLPSTPVS PIELDAKKSP LALLAQTCSQ IGKPDPAPSK LSAVTGSSAS
     GDKESKSVPL KLSDIGAEDK SSFKPYSKHP DKKDQSASDK SGFRVPSAAC PPFTPRTGSP
     GSPRTPPPPS EPKASSECTD KKEMEQCAKT APPDGSAHGR LSTELTHSEG TAGCKSLSAA
     PSPTPASSSS SSSSVLGSGL VAPVSPYKPG HTVFPLPPAS MSYPATLAGA YAGYPPQFLA
     HGVSLDPSKG SSLVGAQLST LGCTGKSAAS SPLTGASPPS VMTASLCRDP YCLSYHCASQ
     LGAGATCAHD LKSGYPLVYP SHALHGVSPP SLPGHPLYPY GFMLPNDPLP HVCNWVSATG
     PCDKRFSSSE ELLGHLRTHT AFPGATDKLL PGYPSSSSLA AAAMACHMHM PPTGASPGPL
     TLRSPHHHPL GLSSSRYHPY SKSPLPSGGA PVPMPAATGH YYSPYALYGQ RLTTASALGY
     Q